Amoxicillin | 阿莫西林

MCE 国际站：Amoxicillin

中文名：阿莫西林

CAS：26787-78-0

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：阿莫西林（Amoxycillin）是一种抗生素，具有良好的口服吸收和广谱抗菌活性。阿莫西林抑制细胞壁中多肽的生物合成，从而抑制细胞生长^[1][2][3]。

体外：阿莫西林 (Amoxycillin)（1-100 µM；24 小时；L. acidophilus）以剂量依赖性方式减少活细胞并增加细胞壁破裂程度^[1] .

体内：阿莫西林（Amoxycillin）（7 mg/kg；ih；雌性 ICR/瑞士小鼠）在 1 mg/L 或更少时抑制品系数量并提高大鼠的存活率^[2]。阿莫西林 (Amoxycillin) (1.6-9.5 mg/kg; po; daily, for 7 or 14 days; swiss albino mice) 在小鼠中具有抗沙眼衣原体感染的作用^[3]。

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研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

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参考文献：[1]. Geddes AM, et al. Introduction: historical perspective and development of amoxicillin/clavulanate. Int J Antimicrob Agents. 2007 Dec;30 Suppl 2:S109-12.

[2]. Handsfield HH,et al. Amoxicillin, a new penicillin antibiotic. Antimicrob Agents Chemother. 1973 Feb;3(2):262-5.

[3]. Guo Y, et, al. Metabolic response of Lactobacillus acidophilus exposed to amoxicillin. J Antibiot (Tokyo). 2022 May;75(5):268-281.[4]. Andes D, et, al. In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: application to breakpoint determinations. Antimicrob Agents Chemother. 1998 Sep;42(9):2375-9.

[5]. Kramer MJ, et, al. Activity of oral amoxicillin, ampicillin, and oxytetracycline against infection with chlamydia trachomatis in mice. J Infect Dis. 1979 Jun;139(6):717-9.