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国际站:(S)-Mephenytoin
CAS:70989-04-7
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:(S)-Mephenytoin ((+)-Mephenytoin) 是一种抗惊厥药。 (S)-Mephenytoin 是细胞色素 P450 (CYP) 亚型 CYP2C19 的底物。 (S)-Mephenytoin 可用于细胞色素 P450 代谢的分析[1][2]。
体外:在细胞色素 b5 存在的情况下,所有五种纯化的细胞色素 P-450 制剂[1] 对 S-美芬妥英的 Km 均为 1.25 mM。
参考文献:[1]. Shimada T, et, al. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J Biol Chem. 1986 Jan 15;261(2):909-21.[2]. Goldstein JA, et, al. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33(7):1743-52.
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