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国际站:Atropine
中文名:阿托品
CAS:51-55-8
品牌:MedChemExpress (MCE)
存储条件:-20°C, stored under nitrogen
生物活性:Atropine (Tropine tropate) 是一种竞争性毒蕈碱型乙酰胆碱受体 (mAChR) 拮抗剂,对人类 mAChR MIC50 值为 0.39 和 0.71 nM< sub>4 和 Chicken mAChR M4。阿托品抑制 ACh 诱导的人肺静脉松弛。阿托品可用于抗近视和心动过缓的研究[1][2][3][4]。 IC50 和目标:IC50:0.39 nM(人 mAChR M4)和 0.71 nM(鸡 mAChR M4)[3] 。
体外:阿托品(Tropine tropate;1 μM;肺静脉和动脉)抑制 ACh 诱导的人肺静脉松弛[4]。
体内:阿托品(Tropine tropate;10 mg/kg;ip;一次,持续 40 分钟;Peromyscus sp.)抑制通常在麻木期间发生的心律失常[2]。
参考文献:[1]. McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8.[2]. Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57.[3]. Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791.[4]. Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8.
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