Revolutionizing cancer treatment with aggregation-induced emission luminogens. Gao et al. achieved a remarkable breakthrough with aggregation-induced emission luminogens (AIEgens) for precise cancer diagnosis and treatment. Their innovative AIEgens, TBBCyP and TBTCyP, designed with a D-A-π-A structure, offer exceptional brightness and efficiency in photodynamic therapy (PDT). TBBCyP and TBTCyP's unique properties, including a weaker twisted intramolecular charge transfer (TICT) effect and narrower singlet-triplet energy gap, enable precise cancer eradication. This groundbreaking advancement promises a brighter and healthier future in cancer therapy.