Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation

背景回顾：Reactive oxygen signaling regulates numerous biological processes, including stress responses in plants. Redox sensors transduce reactive oxygen signals into cellular responses. 

主要发现：We present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog (QSOX1) is a redox sensor that negatively regulates immunity against a bacterial pathogen. 

结果1-表达模式：The expression level of QSOX1 is inversely correlated with pathogen-induced ROS accumulation. 

结果2-功能机制：QSOX1 both senses and regulates ROS levels through interaction with and redox-mediated regulation of S-nitrosoglutathione reductase that, consistent with previous findings, influences reactive nitrogen-mediated regulation of ROS generation. 

结论：Collectively, our data indicate that QSOX1 is a redox sensor that negatively regulates plant immunity by linking reactive oxygen- and reactive nitrogen-signaling to limit ROS production.

 摘 要 

活性氧信号转导调控很多生物过程，包括植物的应激响应。氧化还原传感器会将活性氧信号转化为细胞响应。本文中，作者报道的生化证据表明，植物Quiescin巯基氧化酶同源蛋白QSOX1是一种氧化还原传感器，负调节植物对细菌病原体的免疫。QSOX1的表达水平与病原菌诱导的ROS积累呈负相关。QSOX1不仅可以通过与S-亚硝基谷胱甘肽还原酶的相互作用，还可以通过氧化还原介导的对S-亚硝基谷胱甘肽还原酶的调控，来感知和调节植株体内的ROS水平，从而影响活性氮介导的ROS形成调控。总之，本文的研究数据表明，QSOX1是一种氧化还原传感器，通过关联活性氧信号和活性氮信号来限制ROS的产生，从而负调节植物免疫。