Metabolic Cellular Communications: Feedback Mechanisms between Membrane Lipid Homeostasis and Plant Development

第一作者：Yohann Boutté

第一单位：法国波尔多大学

通讯作者：Yvon Jaillais

Abstract

Membrane lipids are often viewed as passive building blocks of the endomembrane system. However, mounting evidence suggests that sphingolipids, sterols, and phospholipids are specifically targeted by developmental pathways, notably hormones, in a cell- or tissue-specific manner to regulate plant growth and development. Targeted modifications of lipid homeostasis may act as a way to execute a defined developmental program, for example, by regulating other signaling pathways or participating in cell differentiation. Furthermore, these regulations often feed back on the very signaling pathway that initiates the lipid metabolic changes. Here, we review several recent examples highlighting the intricate feedbacks between membrane lipid homeostasis and plant development. In particular, these examples illustrate how all aspects of membrane lipid metabolic pathways are targeted by these feedback regulations. We propose that the time has come to consider membrane lipids and lipid metabolism as an integral part of the developmental program needed to build a plant.

摘要

膜脂通常被看作是内膜系统的被动建筑基块。但是，越来越多的证据显示鞘脂、固醇和磷脂类物质被某些发育通路，尤其是植物激素以细胞或组织特异性的方式所特异性靶向，从而调控植物的生长和发育。脂质内稳态的靶向修饰可能作为一种途径，执行预定义的植物发育进程，比如说调控其它信号通路或者参与细胞分化。此外，这些调控通常会反馈到那些能够起始脂质代谢变化的信号通路上。本文中，作者回顾了一些最近有关膜脂内稳态与植物发育之间复杂反馈的研究进展。这些研究阐述了膜脂代谢通路是如何被这些反馈调控所靶向的。作者提出，我们应该考虑将膜脂和脂质代谢作为植物必需发育进程的组成部分来看待。

通讯作者

**Yvon Jaillais**

个人简介：

2001-2004年，法国里昂高等师范学院，学士；

2004-2007年，法国里昂高等师范学院，博士；

2008-2011年，美国索尔克生物研究所，博士后。

研究方向：

脂质信号转导。

doi: 10.1016/j.devcel.2020.05.005

Journal: Developmental Cell

Published date: June 04, 2020

p.s. 往期植物脂质相关研究链接：