NPR1 mediates a novel regulatory pathway in cold acclimation by interacting with HSFA1 factors
First author: Ema Olate; Affiliations: Centro Investigaciones Biológicas (生物研究中心): Madrid, Spain
Corresponding author: Julio Salinas
NON-EXPRESSER OF PATHOGENESIS-RELATED GENES 1 (NPR1) is a master regulator of plant response to pathogens that confers immunity through a transcriptional cascade mediated by salicylic acid and TGA transcription factors. Little is known, however, about its implication in plant response to abiotic stress (非生物胁迫). Here, we provide genetic and molecular evidence supporting the fact that Arabidopsis NPR1 plays an essential role in cold acclimation (低温适应) by regulating cold-induced gene expression independently of salicylic acid and TGA factors. Our results demonstrate that, in response to low temperature, cytoplasmic (细胞质的) NPR1 oligomers (寡聚物) release monomers (单体) that translocate (改变…的位置) to the nucleus where they interact with heat shock transcription factor 1 (HSFA1) to promote the induction of HSFA1-regulated genes and cold acclimation. These findings unveil an unexpected function for NPR1 in plant response to low temperature, reveal a new regulatory pathway for cold acclimation mediated by NPR1 and HSFA1 factors, and place NPR1 as a central hub integrating cold and pathogen signalling for a better adaptation of plants to an ever-changing (日新月异的) environment.
致病相关基因非表达子NPR1是植物响应病原菌的主要调控子，通过由水杨酸和TGA转录因子介导的转录级联赋予植株免疫。关于NPR1是否参与植物的非生物胁迫响应还不清楚。本文通过遗传学和分子试验证明了拟南芥NPR1独立于水杨酸和TGA转录因子，通过调控冷诱导相关基因的表达在低温适应中发挥重要作用。拟南芥植株在响应低温时细胞质中的NPR1寡聚物会释放出一些单体，这些单体会进入到细胞核中，进而与热休克转录因子HSFA1互作以促进受HSFA1调控的基因的表达和低温适应。本文的研究结果显示了NPR1响应于低温的新功能，同时还揭示了一个新的由NPR1和HSFA1因子通过介导的低温适应调控通路，并且将NPR1确定为整合低温和病原信号的核心基因，有利于植物在不断变化的环境中具有更好的适应能力。
通讯：Julio Salinas（http://cib.csic.es/members/julio-salinas）
doi: https://doi.org/10.1038/s41477-018-0254-2
Journal: Nature Plants
Published date: 24 September, 2018
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