最新研究进展

陈国强小组找到肝癌预后新指标

       陈国强科研团队通过检测727例肝癌病人的癌组织样本中Cbx4的表达，发现高表达Cbx4的肝癌病人手术后5年生存期明显低于低表达Cbx4的肝癌病人，由此提出Cbx4是独立判断肝癌病人预后的重要指标。进一步研究发现，Cbx4的表达水平与血管内皮生长因子（VEGF）的表达及新生血管密度呈高度正相关，即在多种皮下与原位肝癌实验小鼠模型中，Cbx4高表达促进VEGF的产生、新生血管生成和肿瘤的生长与转移；反之，抑制Cbx4表达则明显抑制甚至阻止肝癌细胞在小鼠体内的生长。http://news.sciencenet.cn/htmlnews/2014/1/287549.shtm

知识发现平台  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=22531

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A query = Cbx4 started Tue Jan 14 20:55:21 2014
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C_query_raw: liver cancer Tue Jan 14 20:55:49 2014

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C_query_raw: liver cancer Tue Jan 14 20:55:52 2014

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402 B-terms ready on Tue Jan 14 20:57:31 2014

B-list on Tue Jan 14 22:34:22 2014
1 akt
2 polycomb group
3 proteomic
4 microrna
5 repressor
6 proteomic analysis
7 smad
8 expression vector
9 cadherin
10 hepg2
11 akt mediated
12 construction eukaryotic expression
13 transcriptional
14 finger protein
15 zinc finger protein
16 zinc finger
17 dnmt3a
18 mll
19 transcriptional repression
20 deacetylase
21 bmi1
22 histone deacetylase
23 novel human
24 microrna regulation
25 oncogene
26 dna methyltransferase 3b
27 e cadherin
28 eukaryotic expression vector
29 ctcf
30 growth factor receptor
31 bmi-1
32 transcriptional repressor
33 silencing
34 repression e cadherin
35 expression a novel
36 g1
37 ezh2
38 estrogen signaling
39 cystathionine
40 hepatocellular carcinoma
41 dna binding protein
42 monoclonal antibody human
43 polycomb group protein
44 stem cell self
45 hek293 cell
46 p53
47 co repressor
48 hepatocellular
49 methyltransferase
50 epigenetic
51 corepressor
52 dna methyltransferase
53 monoclonal antibody
54 transcriptional activation
55 lim
56 cell self renewal
57 terminal binding protein
58 apoptosis
59 growth hepatocellular
60 factor receptor
61 histone h3
62 repress
63 hsf2
64 synuclein
65 transcription
66 smad interacting protein
67 novel nuclear
68 ubiquitin
69 derived cell
70 gene expression pattern
71 response hepg2
72 hpc2
73 growth hepatocellular carcinoma
74 dna damage
75 sumo specific protease
76 prostate cancer
77 heterogeneous nuclear ribonucleoprotein
78 hipk2
79 gene expression
80 transcriptional co
81 embryonic stem cell
82 isoform
83 stem cell
84 hodgkin lymphoma
85 ortholog
86 histone
87 prostate
88 cystathionine beta synthase
89 lim protein
90 p53 transcriptional
91 monoclonal
92 overexpressed
93 expression pattern
94 g1 phase
95 hodgkin
96 s phase
97 methylation
98 demethylase
99 gene silencing
100 cell growth hepatocellular
101 c3a cell
102 methylated dna
103 vector
104 polycomb repressive complex
105 terminus
106 sumoylation
107 targeting
108 rna
109 gene encoding
110 self renewal
111 chromobox
112 fibroblast growth factor
113 ranbp2
114 rbp
115 interacting
116 domain
117 genotype
118 suv39h1
119 hepg2 c3a
120 histone demethylase
121 c terminal binding
122 c3a
123 interacting protein
124 repress transcription
125 dna binding
126 sumo

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