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炎症与衰老研究进展与科学计量分析

已有 2648 次阅读 2013-10-23 07:28 |个人分类:信息分析|系统分类:科研笔记

炎症是许多慢性年龄相关疾病，如关节炎、痛风、阿尔茨海默氏症和糖尿病等的共同特征。然而根据耶鲁大学医学院的一项研究，即便是在没有疾病的情况下，炎症也可以导致全身严重的功能丧失，缩短健康寿命——我们生命中没有严重疾病和残疾的一段时间。这项研究被选作 10 月的《细胞-代谢》（Cell Metabolism）杂志的封面文章发表。http://www.bio360.net/news/show/7543.html

分析平台 http://www.pubmedplus.cn/Pubmed/Statistic

检索策略 Inflammation and aging 炎症 and 衰老

检索结果 PUBMED数据库中检索到5978篇

分析结果：

研究主题领域

字段：副主题词搭配

记录数

占%

01.Aging* 衰老3100 篇51.857%

02.Aging/physiology 2044 篇34.192%

03.Inflammation炎症/etiology病因学 1087 篇18.183%

04.Cytokines细胞因子/metabolism代谢 1039 篇17.380%

05.Inflammation/metabolism 841 篇14.068%

06.Aging/metabolism 733 篇12.262%

07.Oxidative Stress* 氧化应激 627 篇10.488%

08.Biological Markers 生物标记物/metabolism 558 篇9.334%

09.Inflammation Mediators 炎症介质/metabolism 530 篇8.866%

10.Aging/immunology 484 篇8.096%

11.Inflammation/physiopathology 438 篇7.327%

12.Inflammation/immunology 413 篇6.909%

13.Inflammation/pathology 407 篇6.808%

14.Cytokines/blood 341 篇5.704%

15.Aging/pathology 331 篇5.537%

16.Interleukin-6 白细胞介素-6 /metabolism 325 篇5.437%

17.Cytokines/genetics 296 篇4.951%

18.Aging/genetics 292 篇4.885%

19.Biological Markers/blood 291 篇4.868%

20.Brain 脑/metabolism 285 篇4.767%

21.Inflammation/blood 259 篇4.333%

22.Tumor Necrosis Factor-alpha 肿瘤坏死因子 /metabolism 255 篇4.266%

23.Inflammation/genetics 240 篇4.015%

24.Brain/pathology 233 篇3.898%

25.Reactive Oxygen Species/metabolism 223 篇3.730%

26.Inflammation/complications 220 篇3.680%

27.Oxidative Stress/physiology 207 篇3.463%

28.Interleukin-6/blood 204 篇3.413%

29.Aging/blood 204 篇3.413%

30.RNA, Messenger/metabolism 198 篇3.312%

31.Aging/drug effects 189 篇3.162%

32.T-Lymphocytes/immunology 188 篇3.145%

33.C-Reactive Protein/metabolism 185 篇3.095%

34.Lipopolysaccharides/pharmacology 181 篇3.028%

35.Cell Aging/physiology 172 篇2.877%

36.Inflammation/drug therapy 169 篇2.827%

37.Signal Transduction/physiology 169 篇2.827%

38.NF-kappa B/metabolism 158 篇2.643%

39.Alzheimer Disease/metabolism 155 篇2.593%

40.Inflammation Mediators/blood 142 篇2.375%

41.Alzheimer Disease/pathology 141 篇2.359%

42.Antioxidants/pharmacology 141 篇2.359%

43.Oxidative Stress/drug effects 135 篇2.258%

44.C-Reactive Protein/analysis 120 篇2.007%

45.Liver/metabolism 115 篇1.924%

46.Inflammation/chemically induced 111 篇1.857%

47.RNA, Messenger/genetics 94 篇1.572%

48.Amyloid beta-Peptides/metabolism 92 篇1.539%

49.Alzheimer Disease/genetics 88 篇

1.472论文作者分布

字段：作者缩写

记录数

占%

01.Ferrucci L 77 篇1.288%

02.Chung HY 69 篇1.154%

03.Franceschi C 63 篇1.054%

04.Harris TB 50 篇0.836%

05.Kritchevsky SB 45 篇0.753%

06.Caruso C 43 篇0.719%

07.Newman AB 42 篇0.703%

08.Guralnik JM 40 篇0.669%

09.Yu BP 39 篇0.652%

10.Pahor M 35 篇0.585%

11.Candore G 33 篇0.552%

12.Lio D 30 篇0.502%

13.Mocchegiani E 29 篇0.485%

14.Monti D 29 篇0.485%

15.Kim DH 28 篇0.468%

16.Ungvari Z 27 篇0.452%

17.Bandinelli S 27 篇0.452%

18.Csiszar A 26 篇0.435%

19.Fried LP 24 篇0.401%

20.Shukitt-Hale B 23 篇0.385%

21.Vasto S 22 篇0.368%

22.Joseph JA 22 篇0.368%

23.Olivieri F 22 篇0.368%

24.Davì G 22 篇0.368%

25.Ha YM 21 篇0.351%

26.Salminen A 21 篇0.351%

27.Colonna-Romano G 20 篇0.335%

28.Wenk GL 20 篇0.335%

29.Lauretani F 20 篇0.335%

30.Vlassara H 20 篇0.335%

31.Kim JM 19 篇0.318%

32.Lee EK 19 篇0.318%

33.Cesari M 19 篇0.318%

34.Malavolta M 18 篇0.301%

35.Giacconi R 18 篇0.301%

36.Kaarniranta K 18 篇0.301%

37.Capri M 18 篇0.301%

38.Balistreri CR 18 篇0.301%

39.Finch CE 18 篇0.301%

40.Chung JH 18 篇0.301%

41.Liu Y 18 篇0.301%

42.Lee J 18 篇0.301%

43.Pedersen BK 17 篇0.284%

44.Meydani M 17 篇0.284%

45.Meydani SN 17 篇0.284%

46.Salvioli S 16 篇0.268%

47.Bickford PC 16 篇0.268%

48.Leeuwenburgh C 16 篇0.268%

49.Bruunsgaard H 15 篇0.251%

50.Cipriano C 12 篇

0.201

研究机构分布

字段：机构

记录数

占%

01.medical school 165 篇2.760%

02.university of california 149 篇2.492%

03.tufts university 134 篇2.242%

04.national institute on aging 123 篇2.058%

05.university hospital 117 篇1.957%

06.national institutes of health 90 篇1.506%

07.pusan national university 70 篇1.171%

08.university of kentucky 59 篇0.987%

09.jean mayer usda human nutrition research center on aging 49 篇0.820%

10.harvard medical school 43 篇0.719%

11.university of bologna 41 篇0.686%

12.molecular inflammation research center for aging intervention 41 篇0.686%

13.university of washington 37 篇0.619%

14.university of florida 37 篇0.619%

15.university of illinois 36 篇0.602%

16.university of michigan 35 篇0.585%

17.columbia university 34 篇0.569%

18.tohoku university 33 篇0.552%

19.mount sinai school of medicine 31 篇0.519%

20.university of copenhagen 31 篇0.519%

21.washington university school of medicine 30 篇0.502%

22.johns hopkins university school of medicine 27 篇0.452%

23.university of south florida 27 篇0.452%

24.university of arizona 25 篇0.418%

25.duke university medical center 24 篇0.401%

26.wake forest university school of medicine 24 篇0.401%

27.university of southern california 24 篇0.401%

28.baylor college of medicine 22 篇0.368%

29.oklahoma medical research foundation 22 篇0.368%

30.university of british columbia 22 篇0.368%

31.jean mayer usda human nutrition research center on aging at tufts university 21 篇0.351%

32.mayo clinic 21 篇0.351%

33.molecular inflammation research center for aging intervention (mrca) 20 篇0.335%

34.albert einstein college of medicine 19 篇0.318%

35.university of texas medical branch 19 篇0.318%

36.human nutrition research center on aging at tufts university 18 篇0.301%

37.university of milan 18 篇0.301%

38.yale university school of medicine 17 篇0.284%

39.university of southampton 17 篇0.284%

40.leiden university medical center 17 篇0.284%

41.kyoto university 17 篇0.284%

42.rigshospitalet 16 篇0.268%

43.university of manchester 16 篇0.268%

44.trinity college 16 篇0.268%

45.university college london 15 篇0.251%

46.new york medical college 15 篇0.251%

47.university of palermo 15 篇0.251%

48.karolinska institutet 14 篇0.234%

49.emory university school of medicine 13 篇0.217%

50.university of kuopio 10 篇

0.167

论文的国家地区分布

字段：国家

记录数

占%

01.美国 2245 篇37.554%

02.意大利 456 篇7.628%

03.日本 334 篇5.587%

04.法国 195 篇3.262%

05.德国 185 篇3.095%

06.加拿大 164 篇2.743%

07.西班牙 136 篇2.275%

08.中国大陆 122 篇2.041%

09.澳大利亚 107 篇1.790%

10.荷兰 95 篇1.589%

11.英国 71 篇1.188%

12.瑞典 69 篇1.154%

13.芬兰 68 篇1.138%

14.瑞士 52 篇0.870%

15.巴西 46 篇0.769%

16.以色列 46 篇0.769%

17.丹麦 46 篇0.769%

18.比利时 45 篇0.753%

19.奥地利 45 篇0.753%

20.中国台湾 37 篇0.619%

21.韩国 30 篇0.502%

22.爱尔兰 29 篇0.485%

23.希腊 28 篇0.468%

24.土耳其 23 篇0.385%

25.印度 22 篇0.368%

26.波兰 20 篇0.335%

27.智利 19 篇0.318%

28.中国香港 16 篇0.268%

29.墨西哥 15 篇0.251%

30.葡萄牙 13 篇0.217%

31.俄罗斯 13 篇0.217%

32.匈牙利 11 篇0.184%

33.阿根廷 11 篇0.184%

34.捷克 10 篇0.167%

35.新西兰 9 篇0.151%

36.塞尔维亚 8 篇0.134%

37.伊朗 7 篇0.117%

38.罗马尼亚 5 篇0.084%

39.沙特阿拉伯 5 篇0.084%

40.斯洛伐克 4 篇0.067%

41.保加利亚 3 篇0.050%

42.尼日利亚 3 篇0.050%

43.约旦 1 篇0.017%

44.马来西亚 1 篇

0.017

论文的期刊分布

字段：期刊

记录数

占%

01.Neurobiol Aging 175 篇2.927%

02.PLoS One 135 篇2.258%

03.Exp Gerontol 112 篇1.874%

04.J Gerontol A Biol Sci Med Sci 112 篇1.874%

05.Mech Ageing Dev 79 篇1.322%

06.Ann N Y Acad Sci 71 篇1.188%

07.J Immunol 61 篇1.020%

08.Aging Cell 55 篇0.920%

09.J Am Geriatr Soc 45 篇0.753%

10.Drugs Aging 42 篇0.703%

11.Proc Natl Acad Sci U S A 37 篇0.619%

12.J Biol Chem 36 篇0.602%

13.Am J Pathol 35 篇0.585%

14.Free Radic Biol Med 34 篇0.569%

15.Aging (Albany NY) 34 篇0.569%

16.Med Hypotheses 33 篇0.552%

17.Atherosclerosis 33 篇0.552%

18.Rejuvenation Res 32 篇0.535%

19.Age (Dordr) 32 篇0.535%

20.Biogerontology 31 篇0.519%

21.Ageing Res Rev 30 篇0.502%

22.Curr Pharm Des 29 篇0.485%

23.J Alzheimers Dis 27 篇0.452%

24.Am J Clin Nutr 27 篇0.452%

25.Aging Dis 26 篇0.435%

26.Arterioscler Thromb Vasc Biol 26 篇0.435%

27.J Neuroinflammation 26 篇0.435%

28.Antioxid Redox Signal 25 篇0.418%

29.J Nutr Biochem 25 篇0.418%

30.Brain Behav Immun 24 篇0.401%

31.J Nutr 24 篇0.401%

32.J Nutr Health Aging 24 篇0.401%

33.J Clin Invest 23 篇0.385%

34.Biochim Biophys Acta 23 篇0.385%

35.Aging Clin Exp Res 23 篇0.385%

36.J Leukoc Biol 22 篇0.368%

37.FASEB J 22 篇0.368%

38.Clin Interv Aging 22 篇0.368%

39.J Neurochem 20 篇0.335%

40.Nutr Rev 20 篇0.335%

41.J Appl Physiol 20 篇0.335%

42.Am J Med 20 篇0.335%

43.Diabetes 19 篇0.318%

44.Infect Immun 19 篇0.318%

45.Biochem Biophys Res Commun 19 篇0.318%

46.J Neurosci Res 18 篇0.301%

47.Neurobiol Dis 18 篇0.301%

48.Immun Ageing 13 篇0.217%

49.Inflamm Res 7 篇0.117%

50.Mediators Inflamm 6 篇

0.100

论文的年代分布

字段：年份

记录数

占%

01.2012 813 篇13.600%

02.2011 749 篇12.529%

03.2010 710 篇11.877%

04.2013 620 篇10.371%

05.2009 592 篇9.903%

06.2008 497 篇8.314%

07.2007 433 篇7.243%

08.2006 395 篇6.608%

09.2005 363 篇6.072%

10.2004 249 篇4.165%

11. 234 篇3.914%

12.2003 200 篇3.346%

13.2002 178 篇2.978%

14.2001 150 篇2.509%

15.2000 122 篇2.041%

16.1998 105 篇1.756%

17.1999 100 篇1.673%

18.1996 93 篇1.556%

19.1997 82 篇1.372%

20.1995 68 篇1.138%

21.1994 59 篇0.987%

22.1993 54 篇0.903%

23.1991 52 篇0.870%

24.1989 49 篇0.820%

25.1992 45 篇0.753%

26.1990 42 篇0.703%

27.1988 30 篇0.502%

28.1985 27 篇0.452%

29.1983 23 篇0.385%

30.1987 21 篇0.351%

31.1980 19 篇0.318%

32.1986 18 篇0.301%

33.1982 16 篇0.268%

34.1984 15 篇0.251%

35.1970 12 篇0.201%

36.1975 11 篇0.184%

37.1979 11 篇0.184%

38.1981 11 篇0.184%

39.1972 9 篇0.151%

40.1978 8 篇0.134%

41.1977 8 篇0.134%

42.1967 6 篇0.100%

43.1964 6 篇0.100%

44.1976 6 篇0.100%

45.1968 6 篇0.100%

46.1971 5 篇0.084%

47.1969 5 篇0.084%

48.1966 4 篇0.067%

49.1974 3 篇0.050%

50.1936 3 篇

0.050

相关疾病研究论文

字段：疾病1(非语义)

记录数

占%

01.tumor 574 篇9.602%

02.necrosis 526 篇8.799%

03.diabetes 511 篇8.548%

04.infection 501 篇8.381%

05.alzheimer's disease 484 篇8.096%

06.atherosclerosis 369 篇6.173%

07.cardiovascular disease 316 篇5.286%

08.obesity 311 篇5.202%

09.infections 216 篇3.613%

10.hypertension 202 篇3.379%

11.dementia 190 篇3.178%

12.arthritis 179 篇2.994%

13.adhesion 176 篇2.944%

14.neurodegenerative diseases 137 篇2.292%

15.metabolic syndrome 133 篇2.225%

16.type 2 diabetes 132 篇2.208%

17.cognitive decline 129 篇2.158%

18.ischemia 123 篇2.058%

19.sepsis 122 篇2.041%

20.inflammatory diseases 122 篇2.041%

21.cardiovascular diseases 119 篇1.991%

22.chronic diseases 116 篇1.940%

23.diabetes mellitus 116 篇1.940%

24.depression 114 篇1.907%

25.endothelial dysfunction 113 篇1.890%

26.cognitive impairment 104 篇1.740%

27.heart failure 104 篇1.740%

28.obese 94 篇1.572%

29.osteoarthritis 93 篇1.556%

30.osteoporosis 91 篇1.522%

31.carcinogenesis 90 篇1.506%

32.neurodegenerative disorders 90 篇1.506%

33.parkinson's disease 89 篇1.489%

34.myocardial infarction 88 篇1.472%

35.cancers 87 篇1.455%

36.chronic obstructive pulmonary disease 78 篇1.305%

37.cvd 77 篇1.288%

38.asthma 75 篇1.255%

39.tumors 75 篇1.255%

40.vascular disease 71 篇1.188%

41.cardiovascular risk factors 70 篇1.171%

42.anemia 67 篇1.121%

43.chronic disease 66 篇1.104%

44.pd 61 篇1.020%

45.tumour 61 篇1.020%

46.adiposity 61 篇1.020%

47.degenerative diseases 57 篇0.953%

48.autoimmune diseases 53 篇0.887%

49.hyperglycemia 51 篇0.853%

50.oa 47 篇

0.786

相关化学物质论文

字段：药物3(Substance)

记录数

占%

01.cytokines 553 篇9.251%

02.biological markers 502 篇8.397%

03.inflammation mediators 398 篇6.658%

04.interleukin-6 392 篇6.557%

05.tumor necrosis factor-alpha 375 篇6.273%

06.c-reactive protein 325 篇5.437%

07.rna, messenger 273 篇4.567%

08.lipopolysaccharides 245 篇4.098%

09.antioxidants 243 篇4.065%

10.reactive oxygen species 206 篇3.446%

11.nf-kappa b 198 篇3.312%

12.amyloid beta-peptides 151 篇2.526%

13.anti-inflammatory agents 122 篇2.041%

14.interleukin-1 116 篇1.940%

15.anti-inflammatory agents, non-steroidal 105 篇1.756%

16.nitric oxide 97 篇1.623%

17.interleukin-1beta 97 篇1.623%

18.interleukin-10 86 篇1.439%

19.cyclooxygenase 2 81 篇1.355%

20.superoxide dismutase 78 篇1.305%

21.nitric oxide synthase type ii 74 篇1.238%

22.glycosylation end products, advanced 71 篇1.188%

23.collagen 70 篇1.171%

24.enzyme inhibitors 67 篇1.121%

25.plant extracts 67 篇1.121%

26.insulin 66 篇1.104%

27.membrane proteins 63 篇1.054%

28.estrogens 62 篇1.037%

29.interferon-gamma 62 篇1.037%

30.free radicals 60 篇1.004%

31.blood glucose 59 篇0.987%

32.amyloid beta-protein precursor 58 篇0.970%

33.cholesterol 58 篇0.970%

34.apolipoproteins e 58 篇0.970%

35.transcription factors 57 篇0.953%

36.neuroprotective agents 57 篇0.953%

37.proteins 56 篇0.937%

38.peptide fragments 55 篇0.920%

39.lipids 54 篇0.903%

40.chemokine ccl2 54 篇0.903%

41.transforming growth factor beta 52 篇0.870%

42.insulin-like growth factor i 51 篇0.853%

43.interleukin-8 51 篇0.853%

44.receptors, immunologic 51 篇0.853%

45.oxygen 50 篇0.836%

46.dinoprostone 48 篇0.803%

47.iron 46 篇0.769%

48.hydrogen peroxide 43 篇0.719%

49.immunoglobulin g 43 篇0.719%

50.anti-bacterial agents 38 篇

0.636

基因本体信息

字段：基因本体(细胞组件)

记录数

占%

01.intracellular 226 篇3.781%

02.host 187 篇3.128%

03.collagen 177 篇2.961%

04.extracellular matrix 109 篇1.823%

05.peroxisome 68 篇1.138%

06.chromatin 33 篇0.552%

07.endoplasmic reticulum 31 篇0.519%

08.cell surface 31 篇0.519%

09.cytoplasm 28 篇0.468%

10.chromosome 20 篇0.335%

11.basement membrane 16 篇0.268%

12.plasma membrane 15 篇0.251%

13.cytoskeleton 15 篇0.251%

14.cell wall 10 篇0.167%

15.mitochondrial respiratory chain 10 篇0.167%

16.axon 8 篇0.134%

17.sarcoplasmic reticulum 5 篇0.084%

18.cellular_component 4 篇0.067%

19.myelin sheath 2 篇0.033%

20.a band 1 篇0.017%

21.caveola 1 篇0.017%

22.nuclear matrix 1 篇

0.017

字段：基因本体(分子功能)

记录数

占%

01.dna binding 31 篇0.519%

02.peroxidase activity 4 篇0.067%

03.catalytic activity 4 篇0.067%

04.superoxide dismutase activity 2 篇0.033%

05.map kinase activity 2 篇0.033%

06.phospholipase a2 activity 1 篇

0.017

字段：基因本体(生物过程)

记录数

占%

01.aging 2967 篇49.632%

02.signaling 572 篇9.568%

03.growth 552 篇9.234%

04.apoptosis 402 篇6.725%

05.behavior 101 篇1.690%

06.cytokine production 92 篇1.539%

07.angiogenesis 91 篇1.522%

08.cell cycle 88 篇1.472%

09.signal transduction 87 篇1.455%

10.neurogenesis 55 篇0.920%

11.localization 53 篇0.887%

12.autophagy 49 篇0.820%

13.sleep 37 篇0.619%

14.cell growth 34 篇0.569%

15.innate immune response 31 篇0.519%

16.chemotaxis 28 篇0.468%

17.cell cycle arrest 25 篇0.418%

18.hypersensitivity 24 篇0.401%

19.tissue homeostasis 23 篇0.385%

20.complement activation 22 篇0.368%

21.translation 20 篇0.335%

22.reproduction 20 篇0.335%

23.proteolysis 20 篇0.335%

24.t cell activation 16 篇0.268%

25.t cell proliferation 15 篇0.251%

26.t cell differentiation 7 篇0.117%

27.s phase 6 篇0.100%

28.ossification 6 篇0.100%

29.m phase 2 篇0.033%

30.catabolic process 2 篇0.033%

31.b cell differentiation 2 篇0.033%

32.b cell proliferation 1 篇0.017%

33.regulation of cell cycle 1 篇0.017%

34.feeding behavior 1 篇0.017%

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