许培扬
砒霜治疗白血病研究文献中的知识发现
2013-2-13 10:23
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标签:知识, 治疗, 白血病
砒霜治疗白血病研究文献中的知识发现

从研究文献中发现隐含的知识概念,对科研选题和相关研究也许有启发作用和参考价值。

检索用词:
A-query: leukemia 
C-query: arsenic trioxide

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 1248articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 20129 and can be accessed from the start page after you leave this session. There are 5174 terms on the current B-list (砒霜治疗白血病研究文献中发现904个相关知识概念 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.


详细信息见:
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=20129

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/umls.cgi?task=filter&ID=20129

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi


基因和分子序列(138个)知识发现如下:

job id # 20129 started Tue Feb 12 20:21:26 2013
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: leukemia Tue Feb 12 20:22:01 2013

A query = leukemia started Tue Feb 12 20:22:02 2013
A query resulted in 50000 titles
C_query_raw: leukemia Tue Feb 12 20:22:04 2013

C: leukemia 251106

A: pubmed_query_A 251106

AC: ( leukemia ) AND ( leukemia ) 251106

C_query_raw: arsenic trioxide Tue Feb 12 20:22:16 2013

C: arsenic trioxide 2378

A: pubmed_query_A 251106

AC: ( leukemia ) AND ( arsenic trioxide ) 1248

C_query_raw: arsenic trioxide Tue Feb 12 20:22:22 2013

C: arsenic trioxide 2378

A: pubmed_query_A 251106

AC: ( leukemia ) AND ( arsenic trioxide ) 1248

C query = arsenic trioxide started Tue Feb 12 20:22:22 2013
C query resulted in 2378 titles
A AND C query resulted in 1248 titles
5174 B-terms ready on Tue Feb 12 20:22:36 2013

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
460 B-terms left after filter executed Tue Feb 12 20:24:22 2013

B-list on Tue Feb 12 20:25:17 2013
1 akt
2 jnk
3 caspase-3
4 caspase
5 cyclin dependent kinase
6 vegf
7 pi3k
8 survivin
9 microrna
10 pml
11 bcr abl
12 herg
13 p38 mapk
14 mtor
15 bcl-2
16 p38
17 nf kappab
18 bcr
19 beta catenin
20 bcl xl
21 topoisomerase
22 c jun n
23 abl
24 transcription factor
25 p16 gene
26 socs-1
27 notch1
28 autophagy
29 daxx
30 cyclin
31 c myc
32 cox-2
33 sp1
34 homeobox
35 bax
36 p15ink4b
37 flt-1
38 ccaat enhancer binding
39 mdm2
40 estrogen receptor alpha
41 k ras
42 trim5alpha
43 nkg2d
44 homeobox gene
45 zinc finger protein
46 vegf c
47 p53
48 p27kip1
49 mycn
50 c jun
51 erk1
52 mda-7
53 cdna library
54 notch
55 scid
56 syk
57 rxr
58 evi1
59 cd95
60 trail
61 p27
62 pten
63 p15ink4b gene
64 cdkn2b
65 cdkn2a
66 dmsa
67 c jun nh2-terminal
68 tyrosine kinase
69 related gene
70 socs-1 gene
71 dna methyltransferase
72 foxo3a
73 yy1
74 p glycoprotein
75 caspase-8
76 nadph oxidase
77 cd4
78 nf kappa b
79 histone deacetylase
80 nf
81 topoisomerase i
82 cpg island
83 rho kinase
84 uncoupling protein
85 trf1
86 isoform
87 receptor flt-1
88 methyltransferase
89 ikappab
90 protein kinase
91 mmp-2
92 mds
93 glutathione transferase
94 shp-1
95 sumo-1
96 tumor suppressor
97 bak
98 nd10
99 synergistic induction apoptosis
100 cd133
101 microsatellite
102 gata-3
103 myc
104 cyclin e
105 bim
106 fas
107 rxr alpha
108 ppargamma
109 survivin gene
110 p53 gene
111 apoptosis related gene
112 c kit
113 myc gene
114 sca-1
115 bnip3
116 cyp1a1
117 nrf2
118 mek
119 kdr
120 rhoa
121 c myc gene
122 bcl2
123 ras
124 oncogene
125 fasl
126 telomerase reverse transcriptase
127 cyclin d1
128 pcna
129 tubulin
130 cdna
131 hedgehog gli
132 znf198
133 prostate cancer
134 xpc
135 hsp70
136 hedgehog
137 jab1
138 cell cycle progression








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