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2012年诺贝尔医学奖得主Gurdon JB和Yamanaka S的学术影响力
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2012年诺贝尔医学生物学奖终于出炉，花落John B. Gurdon和Shinya Yamanaka！
斯德哥尔摩时间8日11时30分(北京时间8日17时30分)，由诺贝尔委员会宣布，英国发育生物学家John B. Gurdon和日本生物学家Shinya Yamanaka最终获得2012年诺贝尔生理医学奖。他们的研究主要为“体细胞可以经重编程后转化为可诱导的多能干细胞”领域。
John B. Gurdon教授
John B. Gurdon是英国核转移和基因克隆方面的先锋研究者；2009年与Shinya Yamanaka共同获得有“美国诺贝尔“之称的拉斯科奖（Lasker Award），以表彰他们在基础医学领域的研究发现。
Shinya Yamanaka教授
Shinya Yamanaka是日本京都大学再生医科学研究所教授，iPS细胞研究中心主任，专注于干细胞研究。2008年，曾获颁邵逸夫生命科学与医学奖。
John B. Gurdon和Shinya Yamanaka在“体细胞可以经重编程后转化为可诱导的多能干细胞”的研究发现最终赢得了诺贝尔医学生物学专家委员会的肯定与认可，共同成为2012年诺贝尔医学奖的获奖者。
最后，感谢John B. Gurdon和Shinya Yamanaka在生物医学领域做出的贡献。
John B. Gurdon 因1962年的开创性工作而获奖，这一年他29岁。
Gurdon, J.B. (1962). The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. Journal of Embryology and Experimental Morphology 10:622-640.
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唯一作者概要:GURDON JB
时间跨度=所有年份. 数据库=SCI-EXPANDED. |
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每年出版的文献数
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字段: 作者 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| GURDON JB | 186 | 96.875 % |  | ||
| LASKEY RA | 16 | 8.333 % | | ||
| DEROBERTIS EM | 13 | 6.771 % | | ||
| MOHUN TJ | 12 | 6.250 % | | ||
| GARRETT N | 11 | 5.729 % | | ||
| BROWN DD | 10 | 5.208 % | | ||
| HOPWOOD ND | 9 | 4.688 % | | ||
| KATO K | 9 | 4.688 % | | ||
| LEMAIRE P | 9 | 4.688 % | | ||
| RYAN K | 9 | 4.688 % | |
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字段: 国家/地区 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| ENGLAND | 183 | 95.313 % | | ||
| USA | 24 | 12.500 % | | ||
| FRANCE | 6 | 3.125 % | | ||
| FED REP GER | 5 | 2.604 % | | ||
| SCOTLAND | 4 | 2.083 % | | ||
| CANADA | 2 | 1.042 % | | ||
| JAPAN | 2 | 1.042 % | |
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字段: 文献类型 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| ARTICLE | 147 | 76.563 % | | ||
| REVIEW | 18 | 9.375 % | | ||
| MEETING ABSTRACT | 10 | 5.208 % | | ||
| DISCUSSION | 8 | 4.167 % | | ||
| PROCEEDINGS PAPER | 8 | 4.167 % | | ||
| EDITORIAL MATERIAL | 7 | 3.646 % | |
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字段: 基金资助机构 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| WELLCOME TRUST | 6 | 3.125 % | | ||
| CAMBRIDGE COMMONWEALTH TRUST | 2 | 1.042 % | | ||
| JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE | 2 | 1.042 % | | ||
| NATIONAL RESEARCH FOUNDATION SOUTH AFRICA | 2 | 1.042 % | | ||
| SWEDISH RESEARCH COUNCIL MEDICINE | 2 | 1.042 % | |
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字段: 语种 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
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| ENGLISH | 191 | 99.479 % | | ||
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字段: 语种 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
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字段: 组织 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| UNIV CAMBRIDGE | 102 | 53.125 % | | ||
| MRC | 53 | 27.604 % | | ||
| WELLCOME CRC INST | 26 | 13.542 % | | ||
| CARNEGIE INST WASHINGTON | 10 | 5.208 % | | ||
| NATL INST MED RES | 10 | 5.208 % | | ||
| DEPT ZOOL | 8 | 4.167 % | | ||
| JOHNS HOPKINS UNIV | 8 | 4.167 % | | ||
| PURDUE UNIV | 8 | 4.167 % | | ||
| UNIV OXFORD | 8 | 4.167 % | | ||
| BAYLOR COLL MED | 7 | 3.646 % | |
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字段: 出版年 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| 1983 | 12 | 6.250 % | | ||
| 1977 | 10 | 5.208 % | | ||
| 1978 | 9 | 4.688 % | | ||
| 1989 | 8 | 4.167 % | | ||
| 1999 | 8 | 4.167 % | | ||
| 1996 | 7 | 3.646 % | | ||
| 2002 | 7 | 3.646 % | | ||
| 1993 | 6 | 3.125 % | | ||
| 1994 | 6 | 3.125 % | | ||
| 1997 | 6 | 3.125 % | | ||
| 1998 | 6 | 3.125 % | | ||
| 2005 | 6 | 3.125 % | | ||
| 1970 | 5 | 2.604 % | | ||
| 1973 | 5 | 2.604 % | | ||
| 1976 | 5 | 2.604 % | | ||
| 1992 | 5 | 2.604 % | | ||
| 2001 | 5 | 2.604 % | | ||
| 1974 | 4 | 2.083 % | | ||
| 1982 | 4 | 2.083 % | | ||
| 1985 | 4 | 2.083 % | | ||
| 1986 | 4 | 2.083 % | | ||
| 1987 | 4 | 2.083 % | | ||
| 1991 | 4 | 2.083 % | | ||
| 2000 | 4 | 2.083 % | | ||
| 2004 | 4 | 2.083 % | | ||
| 2008 | 4 | 2.083 % | | ||
| 2010 | 4 | 2.083 % | | ||
| 1971 | 3 | 1.563 % | | ||
| 1972 | 3 | 1.563 % | | ||
| 1979 | 3 | 1.563 % | | ||
| 1984 | 3 | 1.563 % | | ||
| 1995 | 3 | 1.563 % | | ||
| 2003 | 3 | 1.563 % | | ||
| 2011 | 3 | 1.563 % | | ||
| 1980 | 2 | 1.042 % | | ||
| 1981 | 2 | 1.042 % | | ||
| 1988 | 2 | 1.042 % | | ||
| 1990 | 2 | 1.042 % | | ||
| 2006 | 2 | 1.042 % | | ||
| 2007 | 2 | 1.042 % | | ||
| 2009 | 2 | 1.042 % | | ||
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字段: 出版年 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
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字段: 研究方向 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| DEVELOPMENTAL BIOLOGY | 62 | 32.292 % | | ||
| CELL BIOLOGY | 58 | 30.208 % | | ||
| BIOCHEMISTRY MOLECULAR BIOLOGY | 46 | 23.958 % | | ||
| SCIENCE TECHNOLOGY OTHER TOPICS | 43 | 22.396 % | | ||
| LIFE SCIENCES BIOMEDICINE OTHER TOPICS | 15 | 7.813 % | | ||
| ANATOMY MORPHOLOGY | 10 | 5.208 % | | ||
| GENERAL INTERNAL MEDICINE | 9 | 4.688 % | | ||
| GENETICS HEREDITY | 7 | 3.646 % | | ||
| ENVIRONMENTAL SCIENCES ECOLOGY | 3 | 1.563 % | | ||
| EVOLUTIONARY BIOLOGY | 3 | 1.563 % | | ||
| BIOPHYSICS | 2 | 1.042 % | |
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字段: 来源出版物 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
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| NATURE | 20 | 10.417 % | | ||
| PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 19 | 9.896 % | | ||
| DEVELOPMENT | 17 | 8.854 % | | ||
| CELL | 12 | 6.250 % | | ||
| DEVELOPMENTAL BIOLOGY | 11 | 5.729 % | | ||
| JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY | 9 | 4.688 % | | ||
| CIBA FOUNDATION SYMPOSIA | 8 | 4.167 % | | ||
| INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 8 | 4.167 % | | ||
| EMBO JOURNAL | 7 | 3.646 % | | ||
| CURRENT BIOLOGY | 5 | 2.604 % | | ||
| JOURNAL OF MOLECULAR BIOLOGY | 5 | 2.604 % | | ||
| CELL CYCLE | 4 | 2.083 % | | ||
| MECHANISMS OF DEVELOPMENT | 4 | 2.083 % | | ||
| COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY | 3 | 1.563 % | | ||
| GENES DEVELOPMENT | 3 | 1.563 % | | ||
| JOURNAL OF CELLULAR BIOCHEMISTRY | 3 | 1.563 % | | ||
| NATURE CELL BIOLOGY | 3 | 1.563 % | | ||
| PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B BIOLOGICAL SCIENCES | 3 | 1.563 % | | ||
| PROCEEDINGS OF THE ROYAL SOCIETY B BIOLOGICAL SCIENCES | 3 | 1.563 % | | ||
| SEMINARS IN CELL DEVELOPMENTAL BIOLOGY | 3 | 1.563 % | | ||
| ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2 | 1.042 % | | ||
| BIOESSAYS | 2 | 1.042 % | | ||
| COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III SCIENCES DE LA VIE LIFE SCIENCES | 2 | 1.042 % | | ||
| DIFFERENTIATION | 2 | 1.042 % | | ||
| JOURNAL OF CELL BIOLOGY | 2 | 1.042 % | | ||
| METHODS | 2 | 1.042 % | | ||
| METHODS IN CELL BIOLOGY | 2 | 1.042 % | |
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字段: Web of Science 类别 | 记录 计数 | %，共 192 | 柱状图 | 表格中显示的数据行 所有数据行 |
|---|---|---|---|---|---|
| DEVELOPMENTAL BIOLOGY | 62 | 32.292 % | | ||
| CELL BIOLOGY | 58 | 30.208 % | | ||
| BIOCHEMISTRY MOLECULAR BIOLOGY | 46 | 23.958 % | | ||
| MULTIDISCIPLINARY SCIENCES | 43 | 22.396 % | | ||
| BIOLOGY | 15 | 7.813 % | | ||
| ANATOMY MORPHOLOGY | 10 | 5.208 % | | ||
| MEDICINE GENERAL INTERNAL | 9 | 4.688 % | | ||
| GENETICS HEREDITY | 7 | 3.646 % | | ||
| BIOCHEMICAL RESEARCH METHODS | 3 | 1.563 % | | ||
| ECOLOGY | 3 | 1.563 % | | ||
| EVOLUTIONARY BIOLOGY | 3 | 1.563 % | | ||
| BIOPHYSICS | 2 | 1.042 % | |
Shinya Yamanaka 的开创性工作是在2006年44岁时完成，被引6212次。
Takahashi, K., Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
我的预测很准吧，哈哈！
Shinya Yamanaka的论文被引用情况（2010年生理学或医学诺贝尔奖得主预测）
http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&id=365718
日本京都大学 再生医科学研究所干细胞生物学系教授、美国加州旧金山 心血管疾病研究所 高级调查员以及美国加州大学旧金山分校 解剖学教授 Shinya Yamanaka
获奖原因
因在 DNA 因发现干细胞和开发诱导多能干细胞而获奖
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
K Takahashi, S Yamanaka - cell, 2006 - Elsevier
Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear
contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about
factors that induce this reprogramming. Here, we demonstrate induction of pluripotent ...
contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about
factors that induce this reprogramming. Here, we demonstrate induction of pluripotent ...
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
…, M Narita, T Ichisaka, K Tomoda, S Yamanaka - cell, 2007 - repository.kulib.kyoto-u.ac.jp
抄録: Successful reprogramming of differentiated human somatic cells into a pluripotent state
would allow creation of patient-and disease-specific stem cells. We previously reported
generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from ...
would allow creation of patient-and disease-specific stem cells. We previously reported
generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from ...
Generation of germline-competent induced pluripotent stem cells
K Okita, T Ichisaka, S Yamanaka - Nature, 2007 - nature.com
Abstract We have previously shown that pluripotent stem cells can be induced from mouse
fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and
subsequent selection for Fbx15 (also called Fbxo15) expression. These induced ...
fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and
subsequent selection for Fbx15 (also called Fbxo15) expression. These induced ...
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
…, K Okita, Y Mochiduki, N Takizawa, S Yamanaka - Nature …, 2007 - nature.com
Abstract Direct reprogramming of somatic cells provides an opportunity to generate patient-
or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were
generated from mouse fibroblasts by retroviral transduction of four transcription factors: ...
or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were
generated from mouse fibroblasts by retroviral transduction of four transcription factors: ...
Generation of mouse induced pluripotent stem cells without viral vectors
…, M Nakagawa, H Hyenjong, T Ichisaka, S Yamanaka - Science, 2008 - sciencemag.org
Abstract Induced pluripotent stem (iPS) cells have been generated from mouse and human
somatic cells by introducing Oct3/4 and Sox2 with either Klf4 and c-Myc or Nanog and Lin28
using retroviruses or lentiviruses. Patient-specific iPS cells could be useful in drug ...
somatic cells by introducing Oct3/4 and Sox2 with either Klf4 and c-Myc or Nanog and Lin28
using retroviruses or lentiviruses. Patient-specific iPS cells could be useful in drug ...
Generation of pluripotent stem cells from adult mouse liver and stomach cells
…, K Okita, K Takahashi, T Chiba, S Yamanaka - Science …, 2008 - stke.sciencemag.org
Abstract: Induced pluripotent stem (iPS) cells have been generated from mouse and human
fibroblasts by the retroviral transduction of four transcription factors. However, the cell origins
and molecular mechanisms of iPS cell induction remain elusive. This report describes the ...
fibroblasts by the retroviral transduction of four transcription factors. However, the cell origins
and molecular mechanisms of iPS cell induction remain elusive. This report describes the ...
Strategies and new developments in the generation of patient-specific pluripotent stem cells
S Yamanaka - Cell Stem Cell, 2007 - Elsevier
Generating pluripotent stem cells directly from cells obtained from patients is one of the
ultimate goals in regenerative medicine. Two “reprogramming” strategies for the generation
of pluripotent stem cells from somatic cells have been studied extensively: nuclear transfer ...
ultimate goals in regenerative medicine. Two “reprogramming” strategies for the generation
of pluripotent stem cells from somatic cells have been studied extensively: nuclear transfer ...
[PDF][PDF] The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
…, K Takahashi, M Maruyama, M Maeda, S Yamanaka - cell, 2003 - ccsu.edu
... These data indicate analyses demonstrated that nanog is expressed in ES cells, but not in neural
or hematopoietic stem cells (Ra- ... Positions of the probe and ScaI recognition sites (S) used for
Southern blot were shown. ... scribed (Yamanaka et al., 2000, 1998). ...
or hematopoietic stem cells (Ra- ... Positions of the probe and ScaI recognition sites (S) used for
Southern blot were shown. ... scribed (Yamanaka et al., 2000, 1998). ...
Induction of pluripotent stem cells from fibroblast cultures
K Takahashi, K Okita, M Nakagawa, S Yamanaka - Nature protocols, 2007 - nature.com
Abstract Clinical application of embryonic stem (ES) cells faces difficulties regarding use of
embryos, as well as tissue rejection after implantation. One way to circumvent these issues
is to generate pluripotent stem cells directly from somatic cells. Somatic cells can be ...
embryos, as well as tissue rejection after implantation. One way to circumvent these issues
is to generate pluripotent stem cells directly from somatic cells. Somatic cells can be ...
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
K Takahashi, K Mitsui, S Yamanaka - Nature, 2003 - nature.com
Abstract Embryonic stem (ES) cells are pluripotent cells derived from early mammalian
embryos 1, 2. Their immortality and rapid growth make them attractive sources for stem cell
therapies 3; however, they produce tumours (teratomas) when transplanted, which could ...
embryos 1, 2. Their immortality and rapid growth make them attractive sources for stem cell
therapies 3; however, they produce tumours (teratomas) when transplanted, which could ...
https://wap.sciencenet.cn/blog-280034-620710.html
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