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吸烟与风湿性关节炎的关系文献分析与基因知识发现

已有 3857 次阅读 2010-12-15 13:23 |个人分类:信息分析|系统分类:论文交流| 吸烟, 知识发现, 风湿性关节炎, 信息分析

瑞典研究证实烟民易患风湿性关节炎

  研究人员最近对瑞典1200名风湿病患者和871名同龄健康人士进行了对比调查,结果发现,五分之一的风湿病关节炎病例和高达三分之一的重度风湿性关节炎病例是由于吸烟造成的。如果烟民体内含有SE基因,其患重度风湿性关节炎的风险会更高。

http://news.sciencenet.cn/htmlnews/2010/12/241560.shtm

Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke

http://ard.bmj.com/content/early/2010/11/09/ard.2009.120899.short?q=w_ard_ahead_tab

http://www.gopubmed.org/web/gopubmed/1?WEB0vn40i0lvvqodI3I1I00h001000j100200010

Smoking  and  rheumatoid arthritis

717 documents semantically analyzed
1 2 3 
Top Years
Publications
 
2010
 
93
2009
 
85
2008
 
66
2007
 
64
2006
 
47
2005
 
45
2004
 
38
2002
 
29
2001
 
21
2003
 
20
2000
 
19
1997
 
17
1999
 
15
1993
 
13
1998
 
12
1992
 
11
1990
 
11
1986
 
11
1996
 
10
1995
 
10
1 2 3 
1 2 3 
Top Countries
Publications
 
USA
 
169
United Kingdom
 
98
Sweden
 
53
Japan
 
33
Netherlands
 
27
France
 
24
Germany
 
20
Finland
 
18
Italy
 
14
Australia
 
12
Denmark
 
11
Turkey
 
10
Brazil
 
9
Spain
 
8
Canada
 
8
South Korea
 
7
Greece
 
7
Switzerland
 
6
China
 
5
South Africa
 
5
1 2 3 
1 2 3 ...13 
Top Cities
Publications
 
Boston
 
30
Stockholm, Sweden
 
26
Manchester, United Kingdom
 
21
London
 
18
Rochester, MN, USA
 
17
Leiden
 
13
Tokyo
 
10
Stoke-on-Trent
 
8
Helsinki
 
8
Nottingham
 
7
Malmö
 
7
Los Angeles
 
7
Wichita
 
7
Seoul, South Korea
 
6
Baltimore
 
6
Berlin, Germany
 
6
Copenhagen
 
6
Liverpool
 
6
Glasgow
 
6
Huddinge
 
5
1 2 3 ...13 
1 2 3 ...14 
Top Journals
Publications
 
Ann Rheum Dis
 
76
Arth Rheum/ar C Res
 
66
J Rheumatol
 
57
Arthritis Res Ther
 
20
Scand J Rheumatol
 
18
Clin Rheumatol
 
15
Rheumatol Int
 
13
Rheumatology
 
13
Bmc Proc
 
12
Clin Exp Rheumatol
 
11
Rheumatology (oxford)
 
9
Br J Rheumatol
 
9
Arthritis Rheum
 
8
Joint Bone Spine
 
7
J Periodontol
 
7
Curr Opin Rheumatol
 
7
Arch Intern Med
 
7
Semin Arthritis Rheu
 
7
Clin Calcium
 
6
Am J Med
 
6
1 2 3 ...14 
1 2 3 ...171 
Top Terms
Publications
 
Arthritis, Rheumatoid
 
664
Humans
 
643
Arthritis
 
630
Patients
 
459
Middle Aged
 
401
Smoking
 
360
Risk Factors
 
330
Aged
 
317
Adult
 
317
Women
 
150
Incidence
 
136
Prevalence
 
135
Diagnosis
 
130
Evaluation Studies as Topic
 
126
Rheumatoid Factor
 
122
Lung
 
121
Questionnaires
 
114
Odds Ratio
 
107
Confidence Intervals
 
104
Case-Control Studies
 
102
1 2 3 ...171 
1 2 3 ...128 
Top Authors
Publications
 
Klareskog L
 
15
Symmons D
 
14
Aho K
 
14
Alfredsson L
 
13
Karlson E
 
12
Silman A
 
12
Heliövaara M
 
11
Gabriel S
 
10
Mattey D
 
9
Wolfe F
 
9
Padyukov L
 
8
Crowson C
 
8
Turesson C
 
8
Huizinga T
 
7
Criswell L
 
7
Knekt P
 
7
Drosos A
 
6
Dawes P
 
6
Van Der Helm-Van Mil A
 
6
De Vries R
 
6
1 2 3 ...128 

知识发现平台

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

  A-query: Smoking
C-query: rheumatoid arthritis
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 717 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 4246 and can be accessed from the start page after you leave this session. There are 713 terms on the current B-list (233 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=4246

job id # 4246 started Wed Dec 15 01:13:25 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
4246 Search ARROWSMITH A
A_query_raw: Smoking Wed Dec 15 01:13:59 2010

A query = Smoking started Wed Dec 15 01:14:00 2010
A query resulted in 50000 titles
4246 Search ARROWSMITH C
C_query_raw: rheumatoid arthritis Wed Dec 15 01:14:22 2010

C: rheumatoid arthritis 104872

A: pubmed_query_A 160293

AC: ( Smoking ) AND ( rheumatoid arthritis ) 717

C query = rheumatoid arthritis started Wed Dec 15 01:14:23 2010
C query resulted in 50000 titles
A AND C query resulted in 717 titles
9620 B-terms ready on Wed Dec 15 01:17:00 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
713 B-terms left after filter executed Wed Dec 15 01:27:49 2010

713 B-terms left after filter executed Wed Dec 15 01:27:52 2010

B-list on Wed Dec 15 01:32:12 2010
1 adiponectin
2 cox-2
3 drb1
4 toll receptor
5 promoter polymorphism
6 hla drb1
7 akt
8 mthfr
9 codon polymorphism
10 single nucleotide polymorphism
11 fdg
12 mthfr gene
13 erk1
14 methylenetetrahydrofolate reductase
15 gstm1
16 vegf
17 gstt1
18 methylenetetrahydrofolate reductase gene
19 leptin
20 th1
21 baff
22 visfatin
23 body mass index
24 foxp3
25 cd40
26 microrna
27 estrogen receptor beta
28 statin
29 hla dqa1
30 matrix metalloproteinase
31 mannose binding lectin
32 bone mineral density
33 chemokine receptor
34 angiopoietin-2
35 pi3k
36 cyp1a2
37 metabolic syndrome
38 nrf2
39 genome wide
40 mtor
41 il-18
42 ikappab
43 chemokine
44 snp
45 risk allele
46 tlr2
47 cxcr4
48 hdl
49 candidate gene
50 il-6
51 ctla4
52 vitamin d receptor
53 gt g
54 cd8
55 wnt
56 ku
57 survivin
58 mdm2
59 nkg2d
60 p53 codon polymorphism
61 microsatellite
62 endostatin
63 tim-3
64 gene environment
65 adiposity
66 tp53
67 body mass
68 inflammatory bowel disease
69 hip
70 lipocalin
71 promoter polymorphism associated
72 inflammatory gene
73 human endogenous retrovirus
74 susceptibility gene
75 tyrosine kinase
76 toll
77 jak2
78 cyp2c19
79 polymorphism mthfr gene
80 gene promoter polymorphism
81 il-10
82 cd86
83 polymorphism promoter
84 han
85 e selectin
86 interleukin-10 promoter
87 vntr
88 timp-1
89 hif-1alpha
90 p38
91 acr
92 resistin
93 follistatin
94 caspase-8
95 nf kappab
96 fasl
97 cannabinoid receptor
98 polymorphism promoter region
99 adrenomedullin
100 mmp
101 leptin receptor
102 vntr polymorphism
103 tnf alpha
104 cystatin c
105 cd4
106 nos2a
107 histone deacetylase
108 high mobility group
109 early ra
110 htra1
111 aggrecan
112 braf
113 stat3
114 il-1
115 abcg2
116 gene variant
117 egr-1
118 gene susceptibility
119 crp
120 gene promoter
121 glucocorticoid receptor
122 receptor gene
123 dna methyltransferase
124 trail
125 paraoxonase
126 ace gene
127 grp78
128 beta catenin
129 tmd
130 troponin
131 caspase-3
132 hla
133 gene associated
134 angiotensin receptor
135 mmp-9
136 igfbp-3
137 egfr
138 desmoglein
139 tnf
140 tnfalpha
141 cytokine
142 endogenous retrovirus
143 inos
144 igf2
145 il-17
146 ghrelin
147 interleukin
148 exon
149 mmp-3
150 mri
151 rho kinase
152 tb
153 specific intronic
154 grip
155 nf
156 cxcr3
157 cd40 ligand
158 cxcr2
159 cx3cr1
160 copd
161 diabetes
162 tumor necrosis factor
163 twin
164 pten
165 bcl-2
166 dap12
167 intronic
168 allele
169 dna repair gene
170 n acetyltransferase
171 gene schizophrenia
172 diabetes mellitus
173 receptor tyrosine kinase
174 chop
175 promoter
176 estrogen receptor alpha
177 fms
178 endothelin-1 gene
179 il-15
180 fms tyrosine kinase
181 promoter region
182 cd34
183 aggrecan gene
184 iga nephropathy
185 reductase gene
186 ptsd
187 cip1
188 fat mass
189 ra patient
190 race
191 cfh
192 p2x
193 dnmt3b
194 p300
195 matrix gla protein
196 gene association
197 oxide synthase gene
198 p27
199 rct
200 hsp70
201 sri
202 related gene
203 il-13
204 transcription factor
205 atherosclerosis
206 factor beta1 gene
207 ccr7
208 src
209 tea
210 receptor kinase
211 igf i
212 anxiety
213 dnmt1
214 ifn
215 killer
216 iiia gene
217 tgf beta1
218 rage
219 allele risk
220 ppar
221 m d
222 promoter variant
223 igf
224 nadph oxidase
225 htra1 gene
226 interaction a genome
227 codon
228 genome
229 cd44
230 gene peripheral blood
231 aromatase
232 obesity
233 hypertension

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

Smoking cox-2 rheumatoid arthritis
1: COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention. 2010
Add to clipboard

2: COX-2 is Associated with Periodontitis in Europeans. 2010
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3: Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study. 2010
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4: Interaction between COX-2 G-765C and smoking in relation to coronary artery disease in a Chinese Uighur population. 2010
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1: DMARD aurothiomalate inhibits COX-2, MMP-3 and IL-6 expression in chondrocytes by increasing MKP-1 expression and decreasing p38 phosphorylation. 2010
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2: [Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review.] 2010
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3: Adrenomedullin Inhibits IL-1beta-Induced Rheumatoid Synovial Fibroblast Proliferation and MMPs, COX-2 and PGE2 Production. 2010
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4: Lactobacillus casei reduces the Inflammatory Joint Damage Associated with Collagen-Induced Arthritis (CIA) by Reducing the Pro-Inflammatory Cytokines : Lactobacillus casei: COX-2 inhibitor. 2010
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5: Cyclic mechanical stretch downregulates IL-1&#x03B2;-induced COX-2 expression and PGE<inf>2</inf>production in rheumatoid arthritis fibroblast-like synoviocytes. 2010
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6: Ethyl acetate fraction from Cudrania tricuspidata inhibits IL-1beta-induced rheumatoid synovial fibroblast proliferation and MMPs, COX-2 and PGE2 production. 2010
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7: Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease. 2009
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8: The COX-2 inhibitor market withdrawals and prescribing patterns by rheumatologists in patients with gastrointestinal and cardiovascular risk. 2009
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9: Pharmacophore generation and atom-based 3D-QSAR of novel 2-(4-methylsulfonylphenyl)pyrimidines as COX-2 inhibitors. 2009
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