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宾夕法尼亚州立大学化学家Stephen Benkovic的论著被引用情况
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2010年度美国国家科学奖章获得者名单公布
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… , AS Kang, RA Lerner, SJ Benkovic - Proceedings of the …, 1991 - National Acad Sciences
... CARLOS F. BARBAS III*, ANGRAY S. KANG*, RICHARD A. LERNER*, AND STEPHEN J.
BENKOVICt ... Torrey Pines Road, La Jolla, CA 92037; and tDepartment of Chemistry, Pennsylvania
State University, University Park, PA 16802 Contributed by Stephen J. Benkovic, June 21 ...
Cited by 747 - Related articles - All 10 versions
… , E McGowan, X Yu, S Benkovic, P Jantzen, K Wright … - Nature medicine, 1998 - nature.com
Genetic causes of Alzheimer's disease (AD) include mutations in the amyloid precursor protein
(APP), presenilin 1 (PS1), and presenilin 2 (P52) genes 1 . The mutant APP K670N,M67M transgenic
line, Tg2576, shows markedly elevated amyloid -protein (AP) levels at an early age and, ...
Cited by 692 - Related articles - BL Direct - All 4 versions
Genetic causes of Alzheimer's disease (AD) include mutations in the amyloid precursor protein
(APP), presenilin 1 (PS1), and presenilin 2 (P52) genes 1 . The mutant APP K670N,M67M transgenic
line, Tg2576, shows markedly elevated amyloid -protein (AP) levels at an early age and, ...
Cited by 692 - Related articles - BL Direct - All 4 versions
… , AS Kang, M Alting-Mees, DR Burton, SJ Benkovic, RA … - Science, 1989 - sciencemag.org
66. TA Stewart, PK Pattengale, P. Leder, Cell 38, 627 (1984). 67. C. Schoenenberger et al., EMBO
J. 7, 169 (1988). 68. U. Ruther, C. Garber, D. Komitowski, R. Muller, EF Wagner, Nature 325,
412 (1987); U. Ruther, D. Komitowski, FR Schubert, EF Wagner, Oncogenie 4, 861 ...
Cited by 670 - Related articles - BL Direct - All 10 versions
66. TA Stewart, PK Pattengale, P. Leder, Cell 38, 627 (1984). 67. C. Schoenenberger et al., EMBO
J. 7, 169 (1988). 68. U. Ruther, C. Garber, D. Komitowski, R. Muller, EF Wagner, Nature 325,
412 (1987); U. Ruther, D. Komitowski, FR Schubert, EF Wagner, Oncogenie 4, 861 ...
Cited by 670 - Related articles - BL Direct - All 10 versions
[CITATION] Bioorganic mechanisms
Cited by 564 - Related articles - Find in ChinaCat - All 2 versions
… , K Janda, AD Napper, SJ Benkovic, RA … - Cold Spring Harbor …, 1987 - symposium.cshlp.org
... A. TRAMONTANO,* K. JANDA,* AD NAPPER, t SJ BENKOVIC, t AND RA LERNER* ~Department
of Molecular Biology, Research Institute of Scripps Clinic ... There are about 10 s primary binding
specificities in the im- munologic ~1 repertoire, and each can generate, by a process ...
Cited by 404 - Related articles - All 10 versions
... A. TRAMONTANO,* K. JANDA,* AD NAPPER, t SJ BENKOVIC, t AND RA LERNER* ~Department
of Molecular Biology, Research Institute of Scripps Clinic ... There are about 10 s primary binding
specificities in the im- munologic ~1 repertoire, and each can generate, by a process ...
Cited by 404 - Related articles - All 10 versions
… , FG Salinas, SJ Benkovic, MJ Natan, CD … - J. Am. Chem. …, 2000 - ACS Publications
... Lin He, Michael D. Musick, Sheila R. Nicewarner, Frank G. Salinas, Stephen J. Benkovic,
Michael J. Natan, and Christine D. Keating*. ... Metal deposition occurred at a pressure
of 2 × 10 - 6 mbar at 0.2 nm/s, monitored by an internal QCM. ...
Cited by 404 - Related articles - BL Direct - All 4 versions
... Lin He, Michael D. Musick, Sheila R. Nicewarner, Frank G. Salinas, Stephen J. Benkovic,
Michael J. Natan, and Christine D. Keating*. ... Metal deposition occurred at a pressure
of 2 × 10 - 6 mbar at 0.2 nm/s, monitored by an internal QCM. ...
Cited by 404 - Related articles - BL Direct - All 4 versions
RA Lerner, SJ Benkovic, PG Schultz - Science, 1991 - sciencemag.org
... variable amino acids. R Hirschmann, A. Smith 3rd, C. Taylor, P. Benkovic, S. Taylor,
K. Yager, P. Sprengeler, and S. Benkovic (1994) Science 265, 234-237 | Abstract » |
PDF » Expanding the scope of RNA catalysis. Prudent JR ...
Cited by 428 - Related articles - All 7 versions
... variable amino acids. R Hirschmann, A. Smith 3rd, C. Taylor, P. Benkovic, S. Taylor,
K. Yager, P. Sprengeler, and S. Benkovic (1994) Science 265, 234-237 | Abstract » |
PDF » Expanding the scope of RNA catalysis. Prudent JR ...
Cited by 428 - Related articles - All 7 versions
SJ Benkovic, S Hammes-Schiffer - Science, 2003 - sciencemag.org
The seminal hypotheses proposed over the years for enzymatic catalysis are scrutinized. The
historical record is explored from both biochemical and theoretical perspectives. Particular attention
is given to the impact of molecular motions within the protein on the enzyme's catalytic ...
Cited by 359 - Related articles - All 9 versions
The seminal hypotheses proposed over the years for enzymatic catalysis are scrutinized. The
historical record is explored from both biochemical and theoretical perspectives. Particular attention
is given to the impact of molecular motions within the protein on the enzyme's catalytic ...
Cited by 359 - Related articles - All 9 versions
[PDF] from pnas.org… , CF Barbas, KD Janda, SJ Benkovic, … - Proceedings of the …, 1991 - National Acad Sciences
ANGRAY S. KANG*, CARLOS F. BARBAS*, KIM D. JANDA*, STEPHEN J. BENKOVICt, AND
RICHARD A. LERNER** *Departments of Molecular Biology and Chemistry, The Scripps Research
Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037; and tDepartment of ...
Cited by 303 - Related articles - All 11 versions
ANGRAY S. KANG*, CARLOS F. BARBAS*, KIM D. JANDA*, STEPHEN J. BENKOVICt, AND
RICHARD A. LERNER** *Departments of Molecular Biology and Chemistry, The Scripps Research
Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037; and tDepartment of ...
Cited by 303 - Related articles - All 11 versions
JA Peliska, SJ Benkovic - Science, 1992 - sciencemag.org
... articles. Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.
JA Peliska and SJ Benkovic Department of Chemistry, Pennsylvania State University,
University Park 16802. ... Y. Li and S. Carpenter (2001) J. Gen. Virol. ...
Cited by 258 - Related articles - BL Direct - All 5 versions
... articles. Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.
JA Peliska and SJ Benkovic Department of Chemistry, Pennsylvania State University,
University Park 16802. ... Y. Li and S. Carpenter (2001) J. Gen. Virol. ...
Cited by 258 - Related articles - BL Direct - All 5 versions
… V Mizrahi, PA Benkovic, KA Johnson, SJ Benkovic - Biochemistry, 1987 - ACS Publications
... complexes. The rate is not limited by the actual polymerization but by a separate step,
possibly important in ensuring fidelity [Mizrahi, V., Henrie, R. N., Marlier, JF, Johnson,
KA, & Benkovic, S. J. (1985) Biochemistry 24,4010-40181. ...
Cited by 202 - Related articles - All 5 versions
[HTML] from pnas.org… , PT Rajagopalan, SJ Benkovic, S … - Proceedings of the …, 2002 - National Acad Sciences
A network of coupled promoting motions in the enzyme dihydrofolate reductase is identified and
characterized. The present identification is based on genomic analysis for sequence
conservation, kinetic measurements of multiple mutations, and mixed quantum/classical ...
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A network of coupled promoting motions in the enzyme dihydrofolate reductase is identified and
characterized. The present identification is based on genomic analysis for sequence
conservation, kinetic measurements of multiple mutations, and mixed quantum/classical ...
Cited by 190 - Related articles - BL Direct - All 17 versions
[PDF] from 128.111.114.12M Ostermeier, JH Shim, SJ Benkovic - Nat. Biotechnol, 1999 - 128.111.114.12
... Marc Ostermeier, Jae Hoon Shim, and Stephen J. Benkovic* ... ITCHY A IT-A18 1–100 G 101–203
2 (1) IT-A8 1–113 – 114–203 9 (4) IT-A5 1–129 – 130–203 3 (1) IT-A26 1–136 – 137–203 1
(1) IT-A3 1–140 – 141–203 3 (1) IT-A1 1–144 – 145–203 3 (1) IT-A12 1–144 S 146–203 ...
Cited by 202 - Related articles - View as HTML - All 13 versions
... Marc Ostermeier, Jae Hoon Shim, and Stephen J. Benkovic* ... ITCHY A IT-A18 1–100 G 101–203
2 (1) IT-A8 1–113 – 114–203 9 (4) IT-A5 1–129 – 130–203 3 (1) IT-A26 1–136 – 137–203 1
(1) IT-A3 1–140 – 141–203 3 (1) IT-A1 1–144 – 145–203 3 (1) IT-A12 1–144 S 146–203 ...
Cited by 202 - Related articles - View as HTML - All 13 versions
CA Fierke, KA Johnson, SJ Benkovic - Biochemistry, 1987 - ACS Publications
... 4b H2F 0.5 f 0.3 0.22 f 0.06" H4F 0.06 f 0.01 0.1 f 0.01b "K. Taira and S. J. Benkovic.
Dersonal communication. bThis DaDer. served with the inhibitor methotrexate
(Williams et al., 1979; Blakley & Cocco, 1985b). Second, the ...
Cited by 198 - Related articles - All 6 versions
... 4b H2F 0.5 f 0.3 0.22 f 0.06" H4F 0.06 f 0.01 0.1 f 0.01b "K. Taira and S. J. Benkovic.
Dersonal communication. bThis DaDer. served with the inhibitor methotrexate
(Williams et al., 1979; Blakley & Cocco, 1985b). Second, the ...
Cited by 198 - Related articles - All 6 versions
[PDF] from uprm.eduSJ Benkovic, AM Valentine, F … - Annual Review of …, 2001 - annualreviews.org
... 70: 181-208 (Volume publication date July 2001). Stephen J. Benkovic, Ann M. Valentine, and
Frank Salinas. Department of Chemistry ... helicase, T7 polymerase catalyzes the polymerization
of tens of thousands of nucleotides at a rate of approximately 300 nucleotides s −1 . The ...
Cited by 170 - Related articles - BL Direct - All 5 versions
... 70: 181-208 (Volume publication date July 2001). Stephen J. Benkovic, Ann M. Valentine, and
Frank Salinas. Department of Chemistry ... helicase, T7 polymerase catalyzes the polymerization
of tens of thousands of nucleotides at a rate of approximately 300 nucleotides s −1 . The ...
Cited by 170 - Related articles - BL Direct - All 5 versions
RD Kuchta, P Benkovic, SJ Benkovic - Biochemistry, 1988 - ACS Publications
... Robert D. Kuchta, Patricia Benkovic, and Stephen J. Benkovic* ... The template base(s) to be copied
along with the 3'-ter- minal base(s) of the primer/template is (are) included in the text after each
DNA [eg, 9/20-mer (E'&)]. bThe labels containing a letter have a mismatched primer ...
Cited by 162 - Related articles - All 3 versions
... Robert D. Kuchta, Patricia Benkovic, and Stephen J. Benkovic* ... The template base(s) to be copied
along with the 3'-ter- minal base(s) of the primer/template is (are) included in the text after each
DNA [eg, 9/20-mer (E'&)]. bThe labels containing a letter have a mismatched primer ...
Cited by 162 - Related articles - All 3 versions
[HTML] from pnas.org… , M Wall, DC Wahnon, SJ Benkovic - Proceedings of the …, 1999 - National Acad Sciences
... Contributed by Stephen J. Benkovic. ... An expressed fusion protein (F) folds to form an active protein
ligase (1). The enzyme catalyzes an N-to-S acyl shift (2) at the target–I N junction to produce
a thioester intermediate (T), which undergoes transesterification (3) with a side-chain ...
Cited by 155 - Related articles - BL Direct - All 11 versions
... Contributed by Stephen J. Benkovic. ... An expressed fusion protein (F) folds to form an active protein
ligase (1). The enzyme catalyzes an N-to-S acyl shift (2) at the target–I N junction to produce
a thioester intermediate (T), which undergoes transesterification (3) with a side-chain ...
Cited by 155 - Related articles - BL Direct - All 11 versions
Z Wang, W Fast, AM Valentine, SJ Benkovic - Current Opinion in chemical …, 1999 - Elsevier
... Zhigang Wang, Walter Fast, Ann M Valentine and Stephen J Benkovic E-mail The
Corresponding Author. ... The S. maltophilia L1 enzyme shares the lowest sequence identity
with the other known metallo-β-lactamases and belongs to class Bc. ...
Cited by 152 - Related articles - BL Direct - All 4 versions
... Zhigang Wang, Walter Fast, Ann M Valentine and Stephen J Benkovic E-mail The
Corresponding Author. ... The S. maltophilia L1 enzyme shares the lowest sequence identity
with the other known metallo-β-lactamases and belongs to class Bc. ...
Cited by 152 - Related articles - BL Direct - All 4 versions
S Hammes-Schiffer, SJ Benkovic - Biochemistry, 2006 - annualreviews.org
Abstract This review examines the linkage between protein conformational motions and enzyme
catalysis. The fundamental issues related to this linkage are probed in the context of two enzymes
that catalyze hydride transfer, namely dihydrofolate reductase and liver alcohol ...
Cited by 147 - Related articles - BL Direct - All 3 versions
Abstract This review examines the linkage between protein conformational motions and enzyme
catalysis. The fundamental issues related to this linkage are probed in the context of two enzymes
that catalyze hydride transfer, namely dihydrofolate reductase and liver alcohol ...
Cited by 147 - Related articles - BL Direct - All 3 versions
[PDF] from fasebj.orgK Sriram, JM Matheson, SA Benkovic, DB Miller, MI … - The FASEB Journal, 2002 - FASEB
... disease Krishnan Sriram, Joanna M. Matheson, Stanley A. Benkovic, Diane B. Miller, Michael
I. Luster and James P. O'Callaghan ... Key words: brain • neurodegeneration • neuroprotection •
MPTP T he neuropathological basis of Parkinson's disease (PD) involves a progressive ...
Cited by 150 - Related articles - BL Direct - All 5 versions
... disease Krishnan Sriram, Joanna M. Matheson, Stanley A. Benkovic, Diane B. Miller, Michael
I. Luster and James P. O'Callaghan ... Key words: brain • neurodegeneration • neuroprotection •
MPTP T he neuropathological basis of Parkinson's disease (PD) involves a progressive ...
Cited by 150 - Related articles - BL Direct - All 5 versions
ME Dahlberg, SJ Benkovic - Biochemistry, 1991 - ACS Publications
... and KF-DNA,+l-PPi complexes was not observed in correct incorporation [Kuchta, R. D., Mizrahi,
V., Benkovic, P. A., Johnson, K. A., & Benkovic, SJ (1987) Biochemistry 26, 8410-84171 but was
detected in misincorporation [Kuchta, R. D., Benkovic, P. A., & Benkovic, S. J. (1988 ...
Cited by 140 - Related articles - All 5 versions
... and KF-DNA,+l-PPi complexes was not observed in correct incorporation [Kuchta, R. D., Mizrahi,
V., Benkovic, P. A., Johnson, K. A., & Benkovic, SJ (1987) Biochemistry 26, 8410-84171 but was
detected in misincorporation [Kuchta, R. D., Benkovic, P. A., & Benkovic, S. J. (1988 ...
Cited by 140 - Related articles - All 5 versions
… , S Balasubramanian, DP Giedroc, SJ Benkovic - Biochemistry, 1994 - ACS Publications
ABSTRACT: The effect of recombinant nucleocapsid protein (NCp7) from human immunodeficiency
virus type 1 (HIV-I) on HIV-1 reverse transcriptase (HIV-1 RT) catalyzed DNA strand transfer reactions
has been studied using kinetic methods with a defined template-primer model system. ...
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ABSTRACT: The effect of recombinant nucleocapsid protein (NCp7) from human immunodeficiency
virus type 1 (HIV-I) on HIV-1 reverse transcriptase (HIV-1 RT) catalyzed DNA strand transfer reactions
has been studied using kinetic methods with a defined template-primer model system. ...
Cited by 134 - Related articles - BL Direct - All 3 versions
… , MW Frey, C Lively, M Dahlberg, SJ Benkovic - Biochemistry, 1992 - ACS Publications
... The mixture was allowed to react for varying amounts of time (5 ms to 20 s) and chased with MgClz
(10 mM) and dATP (100 pM) as ... For pyrophosphorolysis experiments, the 13/20-mer was elongated
to the [3'-32P]14/20-mer as described earlier (Dahlberg & Benkovic, 1991). ...
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... The mixture was allowed to react for varying amounts of time (5 ms to 20 s) and chased with MgClz
(10 mM) and dATP (100 pM) as ... For pyrophosphorolysis experiments, the 13/20-mer was elongated
to the [3'-32P]14/20-mer as described earlier (Dahlberg & Benkovic, 1991). ...
Cited by 142 - Related articles - BL Direct - All 3 versions
[PDF] from pnas.org… , BN Hay, KD Janda, SJ Benkovic, RA … - Proceedings of the …, 1989 - National Acad Sciences
... (catalytic antibodies/variable gene repertoire/antigen bhding) L. SASTRY*, M. ALTING-MEESt,
W. D. HUSEt, J. M. SHORTt, J. A. SORGE*t, BN HAY*, KD JANDA*, SJ BENKOVIC*t, AND R.
A. LERNER* ... 36, 1-44. 2. Lerner, R. A. & Benkovic, SJ (1988) BioEssays 9, 107-112. ...
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... (catalytic antibodies/variable gene repertoire/antigen bhding) L. SASTRY*, M. ALTING-MEESt,
W. D. HUSEt, J. M. SHORTt, J. A. SORGE*t, BN HAY*, KD JANDA*, SJ BENKOVIC*t, AND R.
A. LERNER* ... 36, 1-44. 2. Lerner, R. A. & Benkovic, SJ (1988) BioEssays 9, 107-112. ...
Cited by 136 - Related articles - All 9 versions
[PDF] from ucsb.eduTC Bruice, SJ Benkovic… - Biochemistry, 2000 - ACS Publications
... Correlative motions appear to participate in the formation of NACs in the catechol
O-methyltransferase E·S complex and in the rate of turnover of dihydrofolate reduction. ... 5.
Cannon, WR, and Benkovic, SJ (1998) J. Biol. Chem. 273, 26257−26250. ...
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... Correlative motions appear to participate in the formation of NACs in the catechol
O-methyltransferase E·S complex and in the rate of turnover of dihydrofolate reduction. ... 5.
Cannon, WR, and Benkovic, SJ (1998) J. Biol. Chem. 273, 26257−26250. ...
Cited by 137 - Related articles - BL Direct - All 8 versions
[PDF] from pnas.org… , JA Peliska, SJ Benkovic - Proceedings of the …, 1992 - National Acad Sciences
... Department of Chemistry, The Pennsylvania State University, 152 Davey Laboratory, University
Park, PA 16802 Contributed by Stephen J. Benkovic, July 20 ... was 50 1.l; aliquots (5 Al) were
removed from the reaction mixture at each time point and quenched by addition of S Al of ...
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... Department of Chemistry, The Pennsylvania State University, 152 Davey Laboratory, University
Park, PA 16802 Contributed by Stephen J. Benkovic, July 20 ... was 50 1.l; aliquots (5 Al) were
removed from the reaction mixture at each time point and quenched by addition of S Al of ...
Cited by 132 - Related articles - BL Direct - All 7 versions
CM Joyce, SJ Benkovic - Biochemistry, 2004 - ACS Publications
... S., Sawaya, MR, and Ellenberger, T. (1999) An open and closed case for all polymerases,
Structure7, R31−R35. ... 17. Dahlberg, ME, and Benkovic, SJ (1991) Kinetic mechanism of DNA
polymerase I (Klenow fragment): identification of a second conformational change and ev.
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... S., Sawaya, MR, and Ellenberger, T. (1999) An open and closed case for all polymerases,
Structure7, R31−R35. ... 17. Dahlberg, ME, and Benkovic, SJ (1991) Kinetic mechanism of DNA
polymerase I (Klenow fragment): identification of a second conformational change and ev.
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KD Janda, D Schloeder, SJ Benkovic, RA … - Science (New York, …, 1988 - ncbi.nlm.nih.gov
1. Science. 1988 Sep 2;241(4870):1188-91. Induction of an antibody that catalyzes the hydrolysis
of an amide bond. Janda KD, Schloeder D, Benkovic SJ, Lerner RA. Department of Molecular
Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037. ...
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1. Science. 1988 Sep 2;241(4870):1188-91. Induction of an antibody that catalyzes the hydrolysis
of an amide bond. Janda KD, Schloeder D, Benkovic SJ, Lerner RA. Department of Molecular
Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037. ...
Cited by 142 - Related articles - All 6 versions
[HTML] from pnas.org… GL Moore, CD Maranas, SJ Benkovic - Proceedings of the …, 2001 - National Acad Sciences
We have developed, experimentally implemented, and modeled in silico a methodology named
SCRATCHY that enables the combinatorial engineering of target proteins, independent of sequence
identity. The approach combines two methods for recombining genes: incremental ...
Cited by 124 - Related articles - BL Direct - All 21 versions
We have developed, experimentally implemented, and modeled in silico a methodology named
SCRATCHY that enables the combinatorial engineering of target proteins, independent of sequence
identity. The approach combines two methods for recombining genes: incremental ...
Cited by 124 - Related articles - BL Direct - All 21 versions
SA Benkovic, JR Connor - The Journal of Comparative …, 1993 - Wiley Online Library
... O 1993 WILEY-LISS, INC. Page 2. 98 SA BENKOVIC AND JR CONNOR al., '87). ... Scale bars =
10 pm in A, B, DF; 20 pm in C. Page 3. Page 4. 100 TABLE 1 Summary of Cellular Distribution
of Ferritin, Transfernn, and Iron in the Rat Brain' SA BENKOVIC AND JR CONNOR ...
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... O 1993 WILEY-LISS, INC. Page 2. 98 SA BENKOVIC AND JR CONNOR al., '87). ... Scale bars =
10 pm in A, B, DF; 20 pm in C. Page 3. Page 4. 100 TABLE 1 Summary of Cellular Distribution
of Ferritin, Transfernn, and Iron in the Rat Brain' SA BENKOVIC AND JR CONNOR ...
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… Osborne, J Schnell, SJ Benkovic, HJ Dyson, PE … - Biochemistry, 2001 - ACS Publications
... Michael J. Osborne, ‡ § Jason Schnell, ‡ Stephen J. Benkovic, H. Jane Dyson, ‡ and Peter E.
Wright* ‡. ... 1000 s - 1 ) exhibits a deuterium isotope effect of 3, an indication that no kinetically
significant reorganization of the Michaelis complex is necessary in the catalytic step (3). ...
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... Michael J. Osborne, ‡ § Jason Schnell, ‡ Stephen J. Benkovic, H. Jane Dyson, ‡ and Peter E.
Wright* ‡. ... 1000 s - 1 ) exhibits a deuterium isotope effect of 3, an indication that no kinetically
significant reorganization of the Michaelis complex is necessary in the catalytic step (3). ...
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[PDF] from pnas.orgSD Putney, SJ Benkovic, PR … - Proceedings of the …, 1981 - National Acad Sciences
... Abbreviations: dATP[aS], the Sp diastereomer of 2'-deoxyadenosine 5'-O-(1-thiotriphosphate);
dAMP[aS] and dNTP[aS] are corresponding a-thio analogs; kb,kilobase(s); bp, base pair(s). 7350
Thepublication costs ofthis article were defrayedin partbypagecharge payment. ...
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... Abbreviations: dATP[aS], the Sp diastereomer of 2'-deoxyadenosine 5'-O-(1-thiotriphosphate);
dAMP[aS] and dNTP[aS] are corresponding a-thio analogs; kb,kilobase(s); bp, base pair(s). 7350
Thepublication costs ofthis article were defrayedin partbypagecharge payment. ...
Cited by 113 - Related articles - All 8 versions
JR Connor, SA Benkovic - Annals of neurology, 1992 - interscience.wiley.com
... only in oligodendrocytes, but also in microglial cells in both human 1211 and rat brains (S. A.
Benkovic and JR Connor, unpublished observations). Also in rat brain (investigations in human
brain are in progress), ferritin and iron are found in tanycytes that line the ventricles. ...
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... only in oligodendrocytes, but also in microglial cells in both human 1211 and rat brains (S. A.
Benkovic and JR Connor, unpublished observations). Also in rat brain (investigations in human
brain are in progress), ferritin and iron are found in tanycytes that line the ventricles. ...
Cited by 111 - Related articles - All 4 versions
… Connor, KL Boeshore, SA Benkovic, … - Journal of …, 1994 - interscience.wiley.com
... Connor JR, Benkovic SA (1992): Iron regulation in the brain: Histo- chemical, biochemical and
molecular considerations. Ann Neurol 32:S51-S61. Connor JR, Menzies SL, St. Martin S, Mufson
EJ (1991): The cellular distribution of transfemn, femtin, and iron in the human hrdin. ...
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... Connor JR, Benkovic SA (1992): Iron regulation in the brain: Histo- chemical, biochemical and
molecular considerations. Ann Neurol 32:S51-S61. Connor JR, Menzies SL, St. Martin S, Mufson
EJ (1991): The cellular distribution of transfemn, femtin, and iron in the human hrdin. ...
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[HTML] from pnas.org… , AE Nixon, JH Shim, SJ Benkovic - Proceedings of the …, 1999 - National Acad Sciences
... Contributed by Stephen J. Benkovic. ... Building on classic examples of protein fragment
complementation, such as ribonuclease S (1) and β-galactosidase (2), researchers have used
protein fragment complementation to examine theories of protein evolution (3), protein folding ( ...
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... Contributed by Stephen J. Benkovic. ... Building on classic examples of protein fragment
complementation, such as ribonuclease S (1) and β-galactosidase (2), researchers have used
protein fragment complementation to examine theories of protein evolution (3), protein folding ( ...
Cited by 105 - Related articles - BL Direct - All 18 versions
… , AB Smith 3rd, CM Taylor, PA Benkovic, SD Taylor, KM … - Science, 1994 - sciencemag.org
... Sci. Tech- nol. B 9, 1061 (1991). 7. J. S. Foster and JE Frommer, Nature 333, 542 (1988). ...
Ralph Hirschmann,* Amos B. Smith 111,* Carol M. Taylor, Patricia A. Benkovic, Scott D.
Taylor, Kraig M. Yager, Paul A. Sprengeler, Stephen J. Benkovic* ...
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... Sci. Tech- nol. B 9, 1061 (1991). 7. J. S. Foster and JE Frommer, Nature 333, 542 (1988). ...
Ralph Hirschmann,* Amos B. Smith 111,* Carol M. Taylor, Patricia A. Benkovic, Scott D.
Taylor, Kraig M. Yager, Paul A. Sprengeler, Stephen J. Benkovic* ...
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[PDF] from pnas.org… , LC Sowers, DP Millar, SJ Benkovic - Proceedings of the …, 1994 - National Acad Sciences
... Duarte, CA 91010; and $Department of Molecular Biology, The Scripps Research Institute, La
Jolla, CA 92037 Contributed by Stephen J. Benkovic, March 30 ... Aliquots (10 1d) of the unwinding
reaction mixture were taken at 10-s intervals and added to 10 Adof quench solution. ...
Cited by 96 - Related articles - BL Direct - All 10 versions
... Duarte, CA 91010; and $Department of Molecular Biology, The Scripps Research Institute, La
Jolla, CA 92037 Contributed by Stephen J. Benkovic, March 30 ... Aliquots (10 1d) of the unwinding
reaction mixture were taken at 10-s intervals and added to 10 Adof quench solution. ...
Cited by 96 - Related articles - BL Direct - All 10 versions
CJ Falzone, PE Wright, SJ Benkovic - Biochemistry, 1994 - ACS Publications
... This exchange process was altered (either removed or made fast on the NMR time scale) by
deleting three hairpin turn forming residues from the loop and filling the gap with a singleglycine
[Li, L., Falzone, CJ, Wright, PE, 8z Benkovic, S. J. (1 992) Biochemistry 32,7826-78331. ...
Cited by 87 - Related articles - BL Direct - All 5 versions
... This exchange process was altered (either removed or made fast on the NMR time scale) by
deleting three hairpin turn forming residues from the loop and filling the gap with a singleglycine
[Li, L., Falzone, CJ, Wright, PE, 8z Benkovic, S. J. (1 992) Biochemistry 32,7826-78331. ...
Cited by 87 - Related articles - BL Direct - All 5 versions
KD Janda, SJ Benkovic, RA Lerner - Science, 1989 - sciencemag.org
... Acad. Sci. USA 85, 5355 (1988). 7. RA Lemer and S. J.Benkovic, Bioassays 9, 107 (1988); A.
Tramontano, KD Janda, AD Napper, SJ Benkovic, R. A. Lemer, Cold Spring Harbor Symp. Quant.
Biol. 52, 91 (1987); K. M. Shokat, CJ Leumann, R. Sugasawara, P. G. Schultz, Angew. ...
Cited by 86 - Related articles - All 7 versions
... Acad. Sci. USA 85, 5355 (1988). 7. RA Lemer and S. J.Benkovic, Bioassays 9, 107 (1988); A.
Tramontano, KD Janda, AD Napper, SJ Benkovic, R. A. Lemer, Cold Spring Harbor Symp. Quant.
Biol. 52, 91 (1987); K. M. Shokat, CJ Leumann, R. Sugasawara, P. G. Schultz, Angew. ...
Cited by 86 - Related articles - All 7 versions
[PDF] from jbc.org… , ME Dahlberg, SJ Benkovic, ND Grindley, CM … - Journal of Biological …, 1992 - ASBMB
... duplex, the 13/ 20-mer, whose preparation, purification, and quantitation have been described
previously (Kuchta et al., 1987; Dahlberg and Benkovic, 1991). ... mixing were 10, 30, and 50 p ~ .
The reaction was quenched with 0.1 M EDTA at time points between 0 and 5 s and the ...
Cited by 102 - Related articles - All 4 versions
... duplex, the 13/ 20-mer, whose preparation, purification, and quantitation have been described
previously (Kuchta et al., 1987; Dahlberg and Benkovic, 1991). ... mixing were 10, 30, and 50 p ~ .
The reaction was quenched with 0.1 M EDTA at time points between 0 and 5 s and the ...
Cited by 102 - Related articles - All 4 versions
[PDF] from psu.eduCL Brummel, INW Lee, Y Zhou, SJ Benkovic, N … - Science, 1994 - nxw.chem.psu.edu
... R Milberg, and S. Mullen for helpful discussions, 5 November 1993; accepted 23 February 1994
A Mass Spectrometric Solution to the Address Problem of Combinatorial Libraries Christopher
L Brummel, Irene NW Lee, Ying Zhou, Stephen J. Benkovic,* Nicholas Winograd* The ...
Cited by 97 - Related articles - BL Direct - All 9 versions
... R Milberg, and S. Mullen for helpful discussions, 5 November 1993; accepted 23 February 1994
A Mass Spectrometric Solution to the Address Problem of Combinatorial Libraries Christopher
L Brummel, Irene NW Lee, Ying Zhou, Stephen J. Benkovic,* Nicholas Winograd* The ...
Cited by 97 - Related articles - BL Direct - All 9 versions
MW Frey, LC Sowers, DP Millar, SJ Benkovic - Biochemistry, 1995 - ACS Publications
... Previous studies with Klenow fragment [Kuchta, R. D., Mizrahi, V., Benkovic, PA, Johnson, KA,
& Benkovic, S. J. (1987) Biochemistry 26, 8410-84171 have revealed the presence of a
nonchemical step prior to chemistry and have identified this conformational change as the rate ...
Cited by 91 - Related articles - BL Direct - All 4 versions
... Previous studies with Klenow fragment [Kuchta, R. D., Mizrahi, V., Benkovic, PA, Johnson, KA,
& Benkovic, S. J. (1987) Biochemistry 26, 8410-84171 have revealed the presence of a
nonchemical step prior to chemistry and have identified this conformational change as the rate ...
Cited by 91 - Related articles - BL Direct - All 4 versions
WR Cannon, SF Singleton, SJ Benkovic - Nature Structural & …, 1996 - nature.com
... | ISI | ChemPort |; Doster, W., Cusack, S. & Petry, W. Dynamical transition of myoglobin revealed
by inelastic neutron scattering. Nature 337, 754−756 (1989). ... Biophys. J. 70, 453−460 (1996). |
PubMed | ISI | ChemPort |; Fierke, CA, Johnson, KA & Benkovic, SJ Construction and ...
Cited by 88 - Related articles - BL Direct - All 3 versions
... | ISI | ChemPort |; Doster, W., Cusack, S. & Petry, W. Dynamical transition of myoglobin revealed
by inelastic neutron scattering. Nature 337, 754−756 (1989). ... Biophys. J. 70, 453−460 (1996). |
PubMed | ISI | ChemPort |; Fierke, CA, Johnson, KA & Benkovic, SJ Construction and ...
Cited by 88 - Related articles - BL Direct - All 3 versions
FR Bryant, SJ Benkovic - Biochemistry, 1979 - ACS Publications
... References Benkovic, S. J., & Schray, KJ (1973) Enzymes 8,201-238. Benkovic, S. J., & Schray,
K. J. (1978) Transition States of Biochemical Processes (Gandour, RD, & Schowen, R. L., Eds.)
pp 493-526, Plenum Press, New York. ... Dudman, NP, & Benkovic, S. J. (1977) J. Am. ...
Cited by 79 - Related articles - All 2 versions
... References Benkovic, S. J., & Schray, KJ (1973) Enzymes 8,201-238. Benkovic, S. J., & Schray,
K. J. (1978) Transition States of Biochemical Processes (Gandour, RD, & Schowen, R. L., Eds.)
pp 493-526, Plenum Press, New York. ... Dudman, NP, & Benkovic, S. J. (1977) J. Am. ...
Cited by 79 - Related articles - All 2 versions
DM Epstein, SJ Benkovic, PE Wright - Biochemistry, 1995 - ACS Publications
... 1987), as are the energetic contributions of active site residues that interact with folate and NADPH
[reviewed in Wagner and Benkovic (1990)l ... Conformational isomerization occurs between two
forms of the DHFR-MTX binary complex (k > 1 s-'), as well as between two forms of ...
Cited by 91 - Related articles - BL Direct - All 5 versions
... 1987), as are the energetic contributions of active site residues that interact with folate and NADPH
[reviewed in Wagner and Benkovic (1990)l ... Conformational isomerization occurs between two
forms of the DHFR-MTX binary complex (k > 1 s-'), as well as between two forms of ...
Cited by 91 - Related articles - BL Direct - All 5 versions
… , SH Nam, JK Lee, CN Yoon, B Mannervik, SJ Benkovic … - Science, 2006 - sciencemag.org
... References and Notes 1. SJ Benkovic, S. Hammes-Schiffer, Science 301, 1196 (2003). 2.
FH Arnold, Nature 409, 253 (2001). 3. A. Schmid et al., Nature 409, 258 (2001). 4. AC Joerger,
S. Mayer, AR Fersht, Proc. Natl. Acad. Sci. USA 100, 5694 (2003). ...
Cited by 83 - Related articles - BL Direct - All 9 versions
... References and Notes 1. SJ Benkovic, S. Hammes-Schiffer, Science 301, 1196 (2003). 2.
FH Arnold, Nature 409, 253 (2001). 3. A. Schmid et al., Nature 409, 258 (2001). 4. AC Joerger,
S. Mayer, AR Fersht, Proc. Natl. Acad. Sci. USA 100, 5694 (2003). ...
Cited by 83 - Related articles - BL Direct - All 9 versions
[PDF] from ucsc.eduDD Cox, SJ Benkovic, LM Bloom, FC … - Journal of the …, 1988 - ACS Publications
... DD Cox,+ S. J. Benkovic,$ LM Bloom,' FC Bradley,+ MJ Nelson,$ L. Que, Jr.,*+ and DE Wallickt
Contribution from the Department of Chemistr , University of Minnesota, Minneapolis. ... (9) Wallick,
DE; Bloom, L. M.; Gaffney, BJ; Benkovic, S. J. Bio- chemistry 1984, 23, 1295-1302. ...
Cited by 85 - Related articles - All 3 versions
... DD Cox,+ S. J. Benkovic,$ LM Bloom,' FC Bradley,+ MJ Nelson,$ L. Que, Jr.,*+ and DE Wallickt
Contribution from the Department of Chemistr , University of Minnesota, Minneapolis. ... (9) Wallick,
DE; Bloom, L. M.; Gaffney, BJ; Benkovic, S. J. Bio- chemistry 1984, 23, 1295-1302. ...
Cited by 85 - Related articles - All 3 versions
JD Stewart, SJ Benkovic - 1995 - nature.com
... | ChemPort |. 12. Stewart, JD, Roberts, VA, Thomas, N., Getzoff, ED & Benkovic, SJ Biochemistry
33, 1991−2003 (1994). 13. Posner, B., Smiley, J., Lee, I. & Benkovic, S. Trends biochem. Sci.
19, 145−150 (1994). | Article | PubMed | ISI | ChemPort |. 14. Stewart, JD et al. Proc. natn ...
Cited by 69 - Related articles - BL Direct - All 6 versions
... | ChemPort |. 12. Stewart, JD, Roberts, VA, Thomas, N., Getzoff, ED & Benkovic, SJ Biochemistry
33, 1991−2003 (1994). 13. Posner, B., Smiley, J., Lee, I. & Benkovic, S. Trends biochem. Sci.
19, 145−150 (1994). | Article | PubMed | ISI | ChemPort |. 14. Stewart, JD et al. Proc. natn ...
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[PDF] from pnas.org… , BL Iverson, SA Iverson, SJ Benkovic, … - Proceedings of the …, 1990 - National Acad Sciences
... Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA
92037; and tDepartment of Chemistry, Pennsylvania State University, University Park,
PA 16802 Contributed by Stephen J. Benkovic, June 1, 1990 ...
Cited by 80 - Related articles - All 9 versions
... Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA
92037; and tDepartment of Chemistry, Pennsylvania State University, University Park,
PA 16802 Contributed by Stephen J. Benkovic, June 1, 1990 ...
Cited by 80 - Related articles - All 9 versions
CE Cameron, SJ Benkovic - Biochemistry, 1997 - ACS Publications
... 19 Å from the catalytic center of the enzyme has large-amplitude backbone motions on the
nanosecond time scale [Epstein, DM, Benkovic, SJ, and ... Single-turnover experiments indicated
that hydride transfer was reduced by 200-fold to a rate of 1.3 s - 1 and was the rate-limiting ...
Cited by 82 - Related articles - BL Direct - All 5 versions
... 19 Å from the catalytic center of the enzyme has large-amplitude backbone motions on the
nanosecond time scale [Epstein, DM, Benkovic, SJ, and ... Single-turnover experiments indicated
that hydride transfer was reduced by 200-fold to a rate of 1.3 s - 1 and was the rate-limiting ...
Cited by 82 - Related articles - BL Direct - All 5 versions
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