http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

Start A-Literature C-Literature B-list Filter Literature

A-query: Alzheimer disease C-query: atorvastatin The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 30 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 22971 and can be accessed from the start page after you leave this session. There are 614 terms on the current B-list (232 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

 

job id # 22971 started Fri Aug 27 03:07:49 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
22971 Search ARROWSMITH A
A_query_raw: Alzheimer diseaseFri Aug 27 03:08:04 2010

A query = Alzheimer disease started Fri Aug 27 03:08:04 2010
A query resulted in 50000 titles
22971 Search ARROWSMITH C
C_query_raw: atorvastatin Fri Aug 27 03:08:19 2010

C: atorvastatin 4272

A: pubmed_query_A 54590

AC: ( Alzheimer disease ) AND ( atorvastatin ) 30

C query = atorvastatin started Fri Aug 27 03:08:20 2010
C query resulted in 4272 titles
A AND C query resulted in 30 titles
8292 B-terms ready on Fri Aug 27 03:10:14 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
614 B-terms left after filter executed Fri Aug 27 03:15:24 2010

614 B-terms left after filter executed Fri Aug 27 03:15:30 2010

614 B-terms left after filter executed Fri Aug 27 03:15:36 2010

614 B-terms left after filter executed Fri Aug 27 03:15:42 2010

614 B-terms left after filter executed Fri Aug 27 03:15:48 2010

B-list on Fri Aug 27 03:20:10 2010
1 cox-2
2 promoter polymorphism
3 jnk
4 akt
5 mtor
6 toll receptor
7 erk1
8 pcsk9
9 caspase
10 ppar gamma
11 tlr4
12 c jun
13 abca1
14 vegf
15 e polymorphism
16 cd40
17 statin
18 cetp
19 cadasil
20 cyp2d6
21 hdl
22 cd40 ligand
23 pi3k
24 paraoxonase gene
25 apoe
26 ppar
27 paraoxonase
28 metabolic syndrome
29 acat
30 e genotype
31 vldl
32 fdg
33 p38
34 p38mapk
35 c jun n
36 nf kappab
37 hmg coa reductase
38 apolipoprotein e
39 akt pkb
40 p38 mapk
41 estrogen receptor alpha
42 hmg coa
43 bdnf
44 candidate gene
45 matrix metalloproteinase
46 cd40l
47 spatial learning
48 cd59
49 at1
50 microrna
51 cd14
52 nadph oxidase
53 fas ligand
54 apolipoprotein a
55 apolipoprotein a i
56 intronic polymorphism
57 erk
58 gsk-3beta
59 apolipoprotein b
60 hdl cholesterol level
61 smad
62 g c polymorphism
63 chemokine
64 cetp gene
65 pkb
66 oxide synthase gene
67 jun
68 abcb1
69 th1
70 leptin
71 stat3
72 caveolin
73 inos
74 hypercholesterolemia
75 sr bi
76 p2x7
77 allele associated
78 toll
79 ldl
80 abcg2
81 signal regulated kinase
82 map kinase
83 fractalkine
84 hif-1
85 lxr
86 pon1
87 notch1
88 bcl-2
89 crp
90 estrogen receptor
91 ubiquitin
92 lc
93 tnfalpha
94 enzyme gene
95 sirt1
96 bim
97 lipoprotein receptor gene
98 genome wide
99 apolipoprotein c
100 cytokine production
101 visfatin
102 creb
103 mcp-1
104 cd36
105 rac1
106 il-6
107 related gene
108 cytokine
109 ace
110 leptin receptor gene
111 intronic
112 platelet activation
113 icam-1
114 ppar alpha
115 mri
116 han
117 alpha7
118 nf
119 hyperlipidemia
120 il-18
121 smad2
122 mmp-2
123 phospholipid transfer protein
124 isoform
125 a4
126 il-1ra
127 rhoa
128 allele
129 serpin
130 hmgcr
131 th2
132 interleukin-10 gene
133 protein kinase
134 chemokine receptor
135 p glycoprotein
136 endothelin
137 tissue inhibitor metalloproteinase
138 promoter variant
139 ref-1
140 bax
141 promoter
142 hmg
143 c vitamin e
144 peroxisome
145 cd95
146 klotho
147 apo
148 transporter
149 connexin43
150 autophagy
151 bone mineral density
152 tgf beta
153 ldlr
154 glucose transporter
155 selenoprotein
156 pcna
157 transcription factor
158 cx3cr1
159 ccr5
160 lecithin cholesterol acyltransferase
161 atherosclerosis
162 ghrelin
163 gene associated
164 pet
165 s6
166 e gene
167 senescence
168 il-10
169 q10
170 protein kinase c
171 rage
172 tnf alpha
173 hyperinsulinemia
174 ca3
175 protein gene
176 lck
177 il-1beta
178 vitamin e
179 cd34
180 protein promoter
181 plasma cholesterol
182 il-1
183 fasting glucose
184 g protein
185 variant allele
186 superoxide dismutase
187 systolic blood pressure
188 diabetes
189 lipoprotein lipase gene
190 cell adhesion molecule
191 cd45
192 decay accelerating factor
193 receptor gene
194 domain
195 parkinson disease
196 alpha gene
197 gtpase
198 cpla2
199 enhancer
200 calcium channel
201 pick
202 gt
203 nadph
204 mscs
205 lipase gene
206 adiposity
207 cd4
208 heme
209 myeloperoxidase
210 triglyceride
211 angiotensin receptor
212 blind
213 meta
214 acyltransferase
215 lipoprotein lipase
216 transglutaminase
217 gene encoding
218 protease
219 tnf
220 cd8
221 renin
222 coa
223 polycystic ovary syndrome
224 study snps
225 asia
226 fas
227 alzheimer disease
228 apo-1
229 lps
230 lysyl oxidase
231 cholesterol
232 cytochrome p450

看看jnk有研究价值吗？

 

Start A-Literature C-Literature B-list Filter Literature

AB literature   B-term   BC literature   Alzheimer disease jnk atorvastatin 1: Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway. 2009 Add to clipboard 2: JNK regulates APP cleavage and degradation in a model of Alzheimer's disease. 2009 Add to clipboard 3: Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression. 2009 Add to clipboard 4: Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. 2009 Add to clipboard 5: Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. 2008 Add to clipboard 6: Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies. 2007 Add to clipboard 7: JNK signalling: a possible target to prevent neurodegeneration. 2007 Add to clipboard 8: Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease. 2006 Add to clipboard 9: Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease. 2006 Add to clipboard 10: Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy. 2005 Add to clipboard 11: JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease. 2003 Add to clipboard 12: Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway. 2003 Add to clipboard 13: Abeta(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. 2003 Add to clipboard 14: Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease. 2003 Add to clipboard 15: Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). 2002 Add to clipboard 16: Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. 2002 Add to clipboard 17: The JNK/c-Jun cascade and Alzheimer's disease. 2002 Add to clipboard 18: c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. 2001 Add to clipboard 19: Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. 2001 Add to clipboard 20: Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. 2001 Add to clipboard 21: Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies. 2001 Add to clipboard 22: Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. 2001 Add to clipboard 23: Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. 2001 Add to clipboard 24: JNK activation is associated with intracellular beta-amyloid accumulation. 2000 Add to clipboard

 

 

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