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A-query: insulin resistance and type 2 diabetes C-query: Alzheimer's disease The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 79 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 22805 and can be accessed from the start page after you leave this session. There are 2891 terms on the current B-list (1403 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 22805 started Fri Aug 27 02:38:26 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
22805 Search ARROWSMITH A
A_query_raw: insulin resistance and type 2 diabetesFri Aug 27 02:38:57 2010

A query = insulin resistance and type 2 diabetes started Fri Aug 27 02:38:58 2010
A query resulted in 14647 titles
22805 Search ARROWSMITH C
C_query_raw: Alzheimer's disease Fri Aug 27 02:39:17 2010

C: Alzheimer's disease 72541

A: pubmed_query_A 14647

AC: ( insulin resistance and type 2 diabetes ) AND ( Alzheimer's disease ) 79

C query = Alzheimer's disease started Fri Aug 27 02:39:18 2010
C query resulted in 50000 titles
A AND C query resulted in 79 titles
16750 B-terms ready on Fri Aug 27 02:43:58 2010

Sem_filter:
Chemicals & Drugs
2891 B-terms left after filter executed Fri Aug 27 02:54:24 2010

2891 B-terms left after filter executed Fri Aug 27 02:54:50 2010

大于90%的相关性知识点：

B-list on Fri Aug 27 02:57:14 2010
1 olanzapine
2 atorvastatin
3 troglitazone
4 p38 mitogen activated
5 risperidone
6 toll receptor
7 simvastatin
8 ubiquitin proteasome
9 orlistat
10 pioglitazone
11 beta catenin signaling
12 glucagon peptide-1
13 insulin signaling
14 codon polymorphism
15 jun n terminal
16 polymorphism angiotensin
17 uncoupling protein
18 fluorodeoxyglucose
19 ppar gamma agonist
20 peptide-1
21 atypical antipsychotic treatment
22 beta catenin
23 association angiotensin
24 insulin signalling
25 fenofibrate
26 ppargamma
27 islet amyloid polypeptide
28 enzyme gene polymorphism
29 generation antipsychotic
30 ppar gamma2
31 ppar gamma
32 n terminal kinase
33 terminal kinase
34 receptor gene polymorphism
35 association angiotensin converting
36 proteasome
37 statin therapy
38 proinflammatory cytokine
39 akt kinase
40 atypical antipsychotic
41 atorvastatin treatment
42 retinoid x receptor
43 inflammatory cytokine
44 123i metaiodobenzylguanidine
45 catenin
46 protein kinase b
47 x receptor
48 nh2-terminal kinase
49 wnt beta catenin
50 apoe deficient mice
51 ppargamma agonist
52 polymorphism angiotensin converting
53 insulin signal
54 suppressor cytokine
55 dependent insulinotropic polypeptide
56 glucagon peptide
57 cannabinoid receptor
58 mapk
59 mitogen activated protein
60 liver x receptor
61 pravastatin
62 islet amyloid
63 metformin
64 effect statin
65 d polymorphism
66 islet amyloid formation
67 angiotensin receptor blocker
68 peroxisome proliferator activated
69 proliferator activated receptor
70 human islet amyloid
71 suppressor cytokine signaling
72 jun nh2-terminal kinase
73 glp-1 receptor
74 raloxifene
75 amp activated protein
76 oxidative stress antioxidant
77 amylin
78 cystatin c
79 insulin sensitizer
80 effect simvastatin
81 vntr
82 ppar alpha
83 metaiodobenzylguanidine
84 glycogen synthase kinase-3
85 cholesteryl ester transfer
86 glycogen synthase kinase-3beta
87 map kinase
88 phosphatidylinositol 3-kinase
89 scavenger receptor
90 glucose dependent insulinotropic
91 cyclooxygenase-2
92 creb
93 statin
94 polymorphism peroxisome proliferator
95 carvedilol
96 impaired glucose
97 receptor modulator
98 insulin receptor signaling
99 vegf
100 receptor gamma ppargamma
101 pro inflammatory cytokine
102 kinase b
103 ester transfer protein
104 derived neurotrophic factor
105 statin treatment
106 signal regulated kinase
107 antipsychotic treatment
108 insulin signalling pathway
109 receptor class b
110 n-3 fatty acid
111 hdl
112 ubiquitin proteasome system
113 single nucleotide
114 mitochondrial dna variant
115 renin angiotensin
116 impaired insulin signaling
117 angiotensin system
118 role ubiquitin proteasome
119 regulated kinase
120 glycogen synthase
121 pi3-kinase akt
122 plasma homocysteine
123 cannabinoid
124 insulin receptor substrate
125 receptor polymorphism
126 glyburide metformin
127 iapp
128 simvastatin patient
129 asymmetric dimethylarginine
130 glycogen synthase kinase
131 cystatin
132 pro12ala polymorphism ppar
133 antipsychotic medication
134 topiramate
135 cardiorespiratory fitness
136 treated risperidone
137 insulin insulin growth
138 t polymorphism
139 apoe
140 degrading enzyme ide
141 ppar
142 amyloid polypeptide iapp
143 atypical antipsychotic drug
144 thiazolidinedione
145 polymorphism apolipoprotein
146 nadph oxidase
147 scavenger receptor class
148 ppargamma ligand
149 role peroxisome proliferator
150 insulin glargine
151 olanzapine risperidone
152 tcm
153 ubiquitination
154 paraoxonase
155 kinase-3
156 epithelium derived factor
157 incretin
158 element binding
159 lipid homeostasis
160 polymorphism insulin
161 activation glycogen synthase
162 inducible nitric oxide
163 enhancer binding protein
164 metaiodobenzylguanidine myocardial scintigraphy
165 lovastatin
166 atypical antipsychotic medication
167 intron polymorphism
168 insulin signaling pathway
169 pioglitazone treatment
170 phosphoinositide 3-kinase
171 chemokine
172 soluble tumor necrosis
173 glucose transporter
174 homocysteine level
175 antioxidant enzyme
176 apolipoprotein e
177 nuclear factor kappab
178 effect atorvastatin
179 finger protein
180 apolipoprotein e polymorphism
181 shc
182 estrogen receptor alpha
183 ldl cholesterol
184 s6 kinase
185 necrosis factor receptor
186 simvastatin atorvastatin
187 valsartan
188 pigment epithelium derived
189 association apolipoprotein
190 antioxidant vitamin
191 receptor kinase
192 endoplasmic reticulum stress
193 er stress
194 antidiabetic
195 phospholipid transfer protein
196 monocyte chemoattractant protein-1
197 melatonin oxidative stress
198 non insulin dependent
199 caveolin gene
200 serum amyloid
201 il-1beta
202 vitamin e c
203 targeting glycogen
204 alternatively spliced
205 protein tyrosine phosphatase
206 liquid chromatography tandem
207 antioxidant defense
208 peripheral insulin
209 kinase pathway
210 3-kinase
211 nitrosative stress
212 effect pioglitazone
213 p44 mitogen
214 forkhead
215 highly active antiretroviral
216 fasting glucose
217 apolipoprotein e4
218 nitric oxide synthase
219 plasminogen activator inhibitor-1
220 glucose metabolism insulin
221 mutation insulin
222 interleukin-1 receptor
223 insulin signal transduction
224 peroxisome proliferator
225 monocyte chemoattractant
226 activated protein kinase
227 pai-1
228 expression insulin
229 serum apolipoprotein
230 igf system
231 protein gene polymorphism
232 cholesterol transport
233 gt t polymorphism
234 receptor insulin
235 interleukin-18
236 impaired insulin
237 pioglitazone not
238 123i metaiodobenzylguanidine myocardial
239 3-kinase akt
240 homocysteine concentration
241 ubiquitin
242 ppar gamma2 pro12ala
243 receptor advanced glycation
244 stress mitochondrial dysfunction
245 atypical antipsychotic agent
246 phosphatase 2a
247 stress activated
248 atypical protein kinase
249 tyrosine phosphatase
250 ubiquitin proteasome pathway
251 receptor blocker
252 unfolded protein response
253 protein phosphatase 2a
254 response glucose
255 pkc
256 g protein beta3
257 forkhead transcription factor
258 interleukin-10 promoter
259 enzyme gene
260 hdl cholesterol
261 creb binding protein
262 fluorodeoxyglucose positron emission
263 novel benzofuran
264 phosphatidylinositol 3-kinase akt
265 p44 mitogen activated
266 incretin hormone
267 insulin aspart
268 lipoprotein receptor related
269 glucose insulin
270 polymorphism codon
271 insulin gene
272 oxidative dna
273 interleukin-1 receptor antagonist
274 interleukin-6 gene polymorphism
275 reticulum stress induced
276 oxide synthase polymorphism
277 insulin gene vntr
278 glyburide
279 homocysteine metabolism
280 divalproex
281 lipoprotein subfraction
282 proteasome pathway
283 insulin receptor
284 comparison olanzapine risperidone
285 polyphenol
286 igf i
287 soluble tnf
288 panax notoginseng
289 mtdna
290 streptozotocin
291 soy phytoestrogen
292 insulin regulated
293 induced insulin
294 leptin receptor
295 i2-imidazoline receptor
296 protein interaction data
297 kinase c activation
298 antipsychotic drug
299 hepatic lipase
300 insulin signaling glucose
301 oxide synthase inhibitor
302 endogenous sex hormone
303 aging insulin
304 oxidative dna damage
305 glucose dependent
306 polymorphism plasminogen activator
307 lipid lowering
308 apolipoprotein e null
309 role glycogen synthase
310 pai-1 gene
311 at1 receptor
312 losartan
313 peptide-1 glp-1
314 proton magnetic
315 insulin glucose
316 serum homocysteine
317 plasma homocysteine concentration
318 association plasma homocysteine
319 toll
320 role ubiquitin
321 endothelial growth factor
322 igf
323 protein coupled receptor
324 insulin therapy
325 neurotrophic factor
326 vascular risk factor
327 mutation mitochondrial dna
328 c polymorphism
329 synthase kinase-3 insulin
330 autotaxin
331 activated protein
332 induced oxidative
333 risperidone or
334 activation p38 mitogen
335 transcription factor
336 calpain
337 lipoprotein metabolism
338 link diabetes
339 oral glucose
340 homocysteine vascular disease
341 mapk pathway
342 ciliary neurotrophic factor
343 tetrahydrofolate reductase
344 drug discovery
345 lipoprotein profile
346 angiotensin converting enzyme
347 mitochondrial trna
348 inhibitor glycogen synthase
349 3-kinase akt signaling
350 acid binding protein
351 diabetes insulin secretion
352 zinc transporter
353 leptin receptor gene
354 kinase c isoform
355 heme oxygenase
356 green tea
357 influence apolipoprotein
358 protein kinase c
359 diet induced insulin
360 interleukin-1
361 kinase signaling
362 inhibition glycogen synthase
363 grape seed
364 transthyretin
365 antioxidant status
366 insulin lipid
367 calcineurin
368 polymorphism interleukin-6
369 prostaglandin e synthase
370 sh sy5y
371 il-6
372 receptor insulin receptor
373 g c polymorphism
374 postmenopausal hormone
375 kinase jnk
376 serine phosphorylation
377 density lipoprotein cholesterol
378 action statin
379 jun
380 interleukin-6 promoter
381 perindopril
382 polymorphism beta2-adrenergic receptor
383 soluble cd14
384 cb1 receptor
385 sex hormone binding
386 association estrogen receptor
387 pi3-kinase akt pathway
388 estrogen receptor
389 mitochondrial trna leu
390 tetrahydrofolate reductase gene
391 antioxidant capacity
392 nuclear receptor
393 alendronate
394 stress apoptosis
395 antipsychotic
396 kinase c
397 interleukin-6
398 expression protein
399 paraoxonase activity
400 advance tcm
401 nuclear factor
402 oxide synthase gene
403 non insulin
404 protein mrna
405 antihypertensive treatment
406 promoter region serotonin
407 anti inflammatory cytokine
408 low hdl cholesterol
409 human insulin
410 glucagon peptide-1 glp-1
411 clozapine
412 p42 p44 mitogen
413 human amylin
414 effect panax
415 angiotensin receptor
416 hydrolase gene polymorphism
417 interleukin-6 receptor
418 dimethylarginine
419 glucose glycated
420 olanzapine a
421 hormone binding globulin
422 tyrosine phosphatase 1b
423 apolipoprotein
424 codon
425 oxygenase-1
426 at2 receptor
427 risperidone or olanzapine
428 apolipoprotein a
429 glcnac
430 intronic
431 ace insertion deletion
432 vitamin b12 folate
433 mapk activation
434 reduce oxidative
435 abdominal fat
436 baseline characteristic
437 p38 mapk
438 effect raloxifene
439 ace inhibitor
440 plasma homocysteine level
441 c isoform
442 c gene polymorphism
443 insulin improve
444 patient treated risperidone
445 antidiabetic agent
446 tnf alpha
447 insulin gene transcription
448 stress induced apoptosis
449 effect ppar
450 insulin metabolism
451 streptozotocin induced
452 genetic variability insulin
453 semicarbazide sensitive amine
454 sensitive amine oxidase
455 ldl
456 c1q
457 protein phosphatase
458 mutation mitochondrial trna
459 antidiabetic drug
460 endothelial nitric oxide
461 containing lipoprotein
462 tyrosine phosphorylation
463 subunit protein phosphatase
464 insulin patient
465 pi3-kinase
466 heme oxygenase-1
467 inflammatory mediator
468 rapamycin
469 paroxetine
470 igf binding protein
471 receptor related protein
472 dna microarray
473 megalin
474 synthase kinase-3 activity
475 docosahexaenoic
476 obesity insulin
477 intron
478 oxidant antioxidant
479 alpha adrenoceptor
480 sleep duration
481 alpha2-heremans schmid glycoprotein
482 postmenopausal estrogen
483 p selectin
484 calcium homeostasis
485 insulin diabetes
486 effect olanzapine
487 kinase mediate
488 t gt
489 a1 adenosine receptor
490 insulin homeostasis
491 apolipoprotein c
492 ppar gamma activator
493 3-kinase signaling pathway
494 cb1 receptor antagonist
495 c promoter
496 vldl
497 mrna expression
498 tcm treatment
499 mutation codon
500 panax
501 g protein coupled
502 cytokine human
503 peptide amyloid
504 factor kappa b
505 adenosine receptor
506 docosahexaenoic acid
507 interleukin-1beta
508 nuclear factor kappa
509 apolipoprotein a i
510 tnf receptor
511 treated risperidone or
512 normal glucose
513 insulin insulin
514 cytokine gene expression
515 link oxidative stress
516 signaling glucose