病毒感染与宿主细胞内胆固醇代谢关系密切。病毒感染可打破宿主细胞内胆固醇的稳态以满足自身生命周期的需要，宿主同样激活防御途径与之对抗。越来越多的研究证实，抑制胆固醇合成通路可增强抗病毒天然免疫应答，干预宿主胆固醇代谢已成为极具前景的抗病毒治疗策略。https://blog.sciencenet.cn/blog-3423233-1365900.html

http://www.pubmedplus.cn/P/SearchQuickResult?wd=51061c8b-dc20-481a-bbe0-13905c9eee91

• 1. Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels.

  
  

  M S Magalhaes,P Smith,J R Portman,L H Jackson-Jones,C C Bain,P Ramachandran,Z Michailidou,R H Stimson,M R Dweck,L Denby,N C Henderson,S J Jenkins,C Bénézech

  Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.

  cbenezec@ed.ac.uk

  Nat Commun (P 2041-1723 E 2041-1723) H指数：248 2021 年 12 卷 1 期 4434 页

  PMID：34290249 相似文献

  文摘 DOI链接 Nature Publishing Group

• 
  

  2. Increased T cell immunoglobulin and mucin domain containing 4 (TIM-4) is negatively correlated with serum concentrations of interleukin-1β in type 2 diabetes.

  
  

  Peiqing Zhao,Hongxing Wang,Tao Li,Chengbin Lei,Xiaoyan Xu,Wei Wang,Xiaohong Liang,Chunhong Ma,Lifen Gao

  Department of Immunology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection & Immunology, Shandong University School of Medicine, Jinan, China.

  
  

  J Diabetes (P 1753-0407 E 1753-0407) H指数：36 2016 年 8 卷 2 期 199-205 页

  PMID：25676395 相似文献

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