Stuart H. Orkin,美国哈佛医学院David G. Nathan特聘儿科教授、霍华德·休斯医学研究所研究员
获奖原因:对血液病遗传基础展开基础性研究,以及推进镰状细胞贫血症和β-地中海贫血症的基因治疗
https://news.sciencenet.cn/htmlnews/2022/9/486641.shtm
https://pubmed.ncbi.nlm.nih.gov/34779027/
Am J Hematol
. 2022 Feb 1;97(2):168-170.
doi: 10.1002/ajh.26407. Epub 2021 Nov 20.
Nobel prize in physiology or medicine 2021, receptors for temperature and touch: Implications for hematology
Affiliations expand
PMID: 34779027
PMCID: PMC9299453
DOI: 10.1002/ajh.26407
Free PMC article
No abstract available
Conflict of interest statement
Immacolata Andolfo and Achille Iolascon declare no conflict of interest. Seth L. Alper is a consultant for and receives research support from Quest Diagnostics, Inc.
Figures
FIGURE 1
Schematic representation of PIEZO1 and…
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References
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat‐activated ion channel in the pain pathway. Nature. 1997;389:816‐824. - PubMed
Coste B, Mathur J, Schmidt M, et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science. 2010;330:55‐60. - PMC - PubMed
Hillery CA, Kerstein PC, Vilceanu D, et al. Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. Blood. 2011;118(12):3376‐3383. - PMC - PubMed
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MeSH terms
Anemia, Sickle Cell / metabolism*
Animals
Calcium / metabolism
Hematology
Humans
Ion Channels / metabolism
Nobel Prize
TRPV Cation Channels / metabolism
Temperature
Thermosensing*
Touch*
Substances
Ion Channels
PIEZO1 protein, human
PIEZO2 protein, human
TRPV Cation Channels
TRPV1 protein, human
Calcium
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