长谷川成人，日本东京都医学科学研究所脑神经科学部主任
Virginia Man-Yee Lee，美国宾夕法尼亚大学病理学和实验医学系阿尔茨海默病研究John H. Ware 3rd 讲席教授、神经退行性疾病研究中心主任
获奖原因：发现TDP-43以及对神经退行性疾病研究的其他贡献。TDP-43是肌萎缩性脊髓侧索硬化症（ALS）和额颞叶变性（FTLD）的病理特征。
https://news.sciencenet.cn/htmlnews/2022/9/486641.shtm
https://pubmed.ncbi.nlm.nih.gov/17095949/
Review
Ann Pharm Fr
. 2006 Sep;64(5):291-307.
doi: 10.1016/s0003-4509(06)75322-6.
[A Nematode Nobel Prize: Caenorhabditis elegans]
[Article in French]
Affiliations expand
PMID: 17095949
Abstract
The Nematode Caenorhabditis elegans (C. elegans) is an established model increasingly used for studying human disease pathogenesis. C. elegans models are based on the mutagenesis of human disease genes conserved in this Nematode or on the transgenesis with disease genes not conserved in C. elegans. Genetic examinations will give new insights on the cellular and molecular mechanisms that are altered in some neurodegenerative diseases like Duchenne's muscular dystrophy, Huntington's disease and Alzheimer's disease. C. elegans may be used for primary screening of new compounds that may be used as drugs in these diseases.
Similar articles
[C. elegans as a model for human inherited degenerative diseases].
Med Sci (Paris). 2003 Dec;19(12):1218-25. doi: 10.1051/medsci/200319121218.PMID: 14691746 Review. French.
Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy.
Int J Mol Sci. 2021 May 5;22(9):4891. doi: 10.3390/ijms22094891.PMID: 34063069 Free PMC article. Review.
Muscular dystrophy: the worm turns to genetic disease.
Curr Biol. 2000 Nov 2;10(21):R795-7. doi: 10.1016/s0960-9822(00)00768-5.PMID: 11084353 Review.
Exp Gerontol. 2006 Oct;41(10):1007-13. doi: 10.1016/j.exger.2006.06.059. Epub 2006 Aug 23.PMID: 16930903 Review.
The worm in us - Caenorhabditis elegans as a model of human disease.
Trends Biotechnol. 2002 Apr;20(4):147-8. doi: 10.1016/s0167-7799(01)01925-4.PMID: 11906745 No abstract available.
Publication types
MeSH terms
Alzheimer Disease / genetics
Alzheimer Disease / physiopathology
Animals
Bacterial Infections / physiopathology
Caenorhabditis elegans / genetics
Caenorhabditis elegans / microbiology
Caenorhabditis elegans / physiology*
Disease Models, Animal
Gametogenesis
Humans
Huntington Disease / genetics
Huntington Disease / physiopathology
Muscular Dystrophy, Duchenne / genetics
Muscular Dystrophy, Duchenne / physiopathology
Neurobiology
Nobel Prize
Reproduction
Related information
LinkOut - more resources
Full Text Sources
http://www.pubmedplus.cn/P/SearchQuickResult?wd=89310736-f09f-4055-9212-0df3cd0b9bbb
| 01. | 2020 | 1 篇 | 1.887% |
| 02. | 2019 | 2 篇 | 3.774% |
| 03. | 2018 | 1 篇 | 1.887% |
| 04. | 2017 | 2 篇 | 3.774% |
| 05. | 2016 | 2 篇 | 3.774% |
| 06. | 2015 | 1 篇 | 1.887% |
| 07. | 2014 | 4 篇 | 7.547% |
| 08. | 2013 | 1 篇 | 1.887% |
| 09. | 2011 | 2 篇 | 3.774% |
| 10. | 2010 | 1 篇 | 1.887% |
| 11. | 2009 | 2 篇 | 3.774% |
| 12. | 2007 | 1 篇 | 1.887% |
| 13. | 2006 | 2 篇 | 3.774% |
| 14. | 2004 | 1 篇 | 1.887% |
| 15. | 2002 | 3 篇 | 5.660% |
| 16. | 2001 | 5 篇 | 9.434% |
| 17. | 2000 | 3 篇 | 5.660% |
| 18. | 1998 | 1 篇 | 1.887% |
| 19. | 1997 | 12 篇 | 22.642% |
| 20. | 1977 | 3 篇 | 5.660% |
| 21. | 1976 | 3 篇 | 5.660% |
| 01. | nature | 5 篇 | 9.434% |
| 02. | science | 4 篇 | 7.547% |
| 03. | jama | 3 篇 | 5.660% |
| 04. | lakartidningen | 3 篇 | 5.660% |
| 05. | duodecim | 2 篇 | 3.774% |
| 06. | lancet | 2 篇 | 3.774% |
| 07. | ned tijdschr geneeskd | 2 篇 | 3.774% |
| 08. | tidsskr nor laegeforen | 2 篇 | 3.774% |
| 09. | acta paediatr | 1 篇 | 1.887% |
| 10. | adv exp med biol | 1 篇 | 1.887% |
| 01. | 英国 | 4 篇 | 7.547% |
| 02. | 美国 | 3 篇 | 5.660% |
| 03. | 中国 | 2 篇 | 3.774% |
| 04. | 荷兰 | 2 篇 | 3.774% |
| 05. | 法国 | 1 篇 | 1.887% |
| 06. | 芬兰 | 1 篇 | 1.887% |
| 07. | 日本 | 1 篇 | 1.887% |
| 08. | 瑞典 | 1 篇 | 1.887% |
| 09. | 沙特阿拉伯 | 1 篇 | 1.887% |
| 10. | 以色列 | 1 篇 | 1.887% |
| 01. | 中国苏州 | 1 篇 | 1.887% |
| 01. | Nobel Prize | 53 篇 | 100.000% |
| 02. | Humans | 46 篇 | 86.792% |
| 03. | History, 20th Century | 36 篇 | 67.925% |
| 04. | Animals | 23 篇 | 43.396% |
| 05. | Prion Diseases | 18 篇 | 33.962% |
| 06. | United States | 17 篇 | 32.075% |
| 07. | Prions | 14 篇 | 26.415% |
| 08. | History, 21st Century | 12 篇 | 22.642% |
| 09. | Parkinson Disease | 11 篇 | 20.755% |
| 10. | Kuru | 9 篇 | 16.981% |
常用聚类 分析报告导出
www.newpubmed.com
地址：北京市海淀区远大路20号宝蓝世纪大厦F座5E
转载本文请联系原作者获取授权，同时请注明本文来自许培扬科学网博客。
链接地址：https://wap.sciencenet.cn/blog-280034-1356768.html?mobile=1
收藏
