英国细胞学家与生物化学家

克里斯汀·德·迪夫（Christian René de Duve，1917年10月2日－2013年5月4日）是一位细胞学家与生物化学家，出生于英国，是比利时移民的后裔。1920年与家人一起回到比利时。

https://baike.baidu.com/item/%E5%85%8B%E9%87%8C%E6%96%AF%E6%B1%80%C2%B7%E5%BE%B7%C2%B7%E8%BF%AA%E5%A4%AB/9556608?fromModule=lemma_inlink

https://pubmed.ncbi.nlm.nih.gov/4609724/

https://pubmed.ncbi.nlm.nih.gov/10976227/

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No abstract available

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Publication types

• Biography

• Historical Article

MeSH terms

• England

• History, 20th Century

• Luxembourg

• Nobel Prize*

• Physiology*

• Romania

Personal name as subject

• A Claude A|CLAUDE

• G E Palade GE|PALADE

• C R De Duve CR|DEDUVE

Abstract

The density-distribution patterns of various enzymes and of labeled materials have been determined by isopycnic centrifugation in a sucrose-0.2 M KCl gradient on homogenates of lymphoid tissues from rats injected with Triton WR-1339, (14)C-labeled dextran, (51)Cr-labeled erythrocytes, and cortisol. The results confirm and extend the conclusion, derived from previous investigations on normal animals, that the lysosomes of lymphoid tissues form two and possibly three, distinct populations. The evidence indicates that the L(19) population belongs to macrophages and the L(15) group to lymphocytes. The L(30) population appears to be associated with a special type of phagocyte with a high capacity for dextran storage. All three populations seem to contribute to the activities found in soluble form in homogenates of normal lymphoid tissues.

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• Lysosomes in lymphoid tissue. II. Intracellular distribution of acid hydrolases.

  Bowers WE, de Duve C.J Cell Biol. 1967 Feb;32(2):339-48. doi: 10.1083/jcb.32.2.339.PMID: 10976226 Free PMC article.

• Lysosomes in lymphoid tissue. I. The measurement of hydrolytic activities in whole homogenates.

  Bowers WE, Finkenstaedt JT, de Duve C.J Cell Biol. 1967 Feb;32(2):325-37. doi: 10.1083/jcb.32.2.325.PMID: 10976225 Free PMC article.

• Lysosomes in skeletal muscle tissue. Zonal centrifugation evidence for multiple cellular sources.

  Canonico PG, Bird JW.J Cell Biol. 1970 May;45(2):321-33. doi: 10.1083/jcb.45.2.321.PMID: 4327573 Free PMC article.

• Lysosomal hydrolases in lymphoid tissue from germ-free and neonatal rats.

  Esterly JR, Standen AC.Experientia. 1971 Aug;27(8):935-6. doi: 10.1007/BF02135755.PMID: 5147267 No abstract available.

• The heterogeneity of lysosomes.

  Davies M.Front Biol. 1975;43(4):305-48.PMID: 820578 Review. No abstract available.

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Cited by

• Lysosomes in lymphoid tissue. II. Intracellular distribution of acid hydrolases.

  Bowers WE, de Duve C.J Cell Biol. 1967 Feb;32(2):339-48. doi: 10.1083/jcb.32.2.339.PMID: 10976226 Free PMC article.

• [The role of the spleen in hemolytic diseases].

  Stutte HJ, Ezumi K.Blut. 1969 May;19(2):99-113. doi: 10.1007/BF01633091.PMID: 5783104 German. No abstract available.

• The subcellular distribution of antigen in macrophages.

  Kölsch E, Mitchison NA.J Exp Med. 1968 Nov 1;128(5):1059-79. doi: 10.1084/jem.128.5.1059.PMID: 5682940 Free PMC article.

• Studies on lysosomes. XI. Characterization of a hydrolase-rich fraction from human lymphocytes.

  Brittinger G, Hirschhorn R, Douglas SD, Weissmann G.J Cell Biol. 1968 May;37(2):394-411. doi: 10.1083/jcb.37.2.394.PMID: 5656398 Free PMC article.

• Lysosomal enzyme changes in mouse spleen cells after antigenic stimulation.

  Jacob KH, Weir DM.Immunology. 1971 Sep;21(3):419-26.PMID: 5568323 Free PMC article.

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References

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1. Proc Soc Exp Biol Med. 1954 Oct;87(1):231-3 - PubMed

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1. Br J Haematol. 1955 Jan;1(1):62-74 - PubMed

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1. Lancet. 1964 Dec 26;2(7374):1371-3 - PubMed

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1. Nature. 1962 Aug 4;195:457-8 - PubMed

Show all 29 references

MeSH terms

• Acid Phosphatase / analysis*

• Animals

• Anti-Inflammatory Agents / pharmacology

• Chromium Radioisotopes

• Detergents / pharmacology

• Dextrans / pharmacology

• Erythrocytes

• Hydrocortisone / pharmacology

• Hydrolases / analysis*

• Lymph Nodes / enzymology

• Lymphoid Tissue / drug effects

• Lymphoid Tissue / enzymology*

• Lysosomes / enzymology*

• Polyethylene Glycols / pharmacology

• Rats

• Spleen / enzymology

• Subcellular Fractions / drug effects

• Subcellular Fractions / enzymology

• Thymus Gland / enzymology

Substances

• Anti-Inflammatory Agents

• Chromium Radioisotopes

• Detergents

• Dextrans

• Polyethylene Glycols

• Hydrolases

• Acid Phosphatase

• Hydrocortisone

• tyloxapol

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