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珍妮特·罗利（Janet Davison Rowley）:癌症遗传学研究的先驱
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珍妮特·戴维森·罗利逝世（Janet Davison Rowley）
——癌症遗传学研究的先驱
诸平
1. 罗利简介
据华盛顿邮报（The Washington Post）报道，美国芝加哥大学(Universityof Chicago)的血液学家和教授珍妮特·戴维森·罗利（Janet Davison Rowley，1925-2013）博士于2013年12月17日在芝加哥市南郊海德公园（Hyde Park）附近的家中因病去世，享年88岁。因为她对于肿瘤学和遗传学研究的杰出贡献，而赢得很多荣誉和奖项。尽管她患有卵巢癌，就在她去世的前几个月依然继续带病坚持工作，甚至骑自行车去校园。可以说一直在与疾病作斗争的过程中，坚持到最后。
罗利1925年4月5日在美国纽约市出生，是其父母唯一的独生女，父母都毕业于芝加哥大学，当罗利2岁时就随父母来到芝加哥大学。1940年年仅15岁的罗利就得到了芝加哥大学实验中学（Universityof Chicago Laboratory Schools）大学先修课程的奖学金资助，因此高中的后两年与大学的前两年合二为一。1944年罗利获得了哲学学士学位，并被芝加哥大学医学院录取，尽管她的入学注册因为女生的配额问题被推迟一年，每一个班级由65名学生组成，但是其中必须有3名女生。1948年，年仅23岁的罗利在芝加哥大学医学院获硕士学位（MD），毕业的当天就与唐纳德·亚当斯·罗利（Donald Adams Rowley）结婚，唐纳德·亚当斯·罗利是一名医师。1961年罗利去牛津大学做博士后，1978年成为全职教授。1972年罗利发现了费城染色体易位的机制——一种与某些白血病相关的遗传异常——9号染色体长臂与22号染色体断臂进行相互易位。由此使她成为肿瘤细胞遗传学研究的先驱。罗利于1996年获盖尔德纳国际奖，1998年获美国国家科学奖章、拉斯克临床医学研究奖。
2.罗利论文年度统计
据PubMed数据库统计结果显示，罗利有400篇论文被该数据库收录，按年统计结果如图1所示。
图1 PubMed数据库收录罗利论文情况
3. 合作者统计结果
罗利400篇被PubMed数据库收录的论文，合作者关系图如图2所示。
图2 罗利合作者关系图
3. 高引论著
最高被引文献多达3232次，下面选择被引用在300次以上的部分论著，供大家参考。
A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
JD Rowley - Landmarks in Medical Genetics: Classic Papers with …, 2004 - books.google.com
Cells from nine consecutive patients with chronic myelogenous leukaemia (CML) have been
analysed with quinacrine fluorescence and various Giemsa staining techniques. The
Philadelphia (Ph1) chromosome in all nine patients represents a deletion of the long arm ...
analysed with quinacrine fluorescence and various Giemsa staining techniques. The
Philadelphia (Ph1) chromosome in all nine patients represents a deletion of the long arm ...
Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia
…, E Morgan, SC Raimondi, JD Rowley… - Proceedings of the …, 1995 - National Acad Sciences
Abstract Chromosomal rearrangements involving band 12p13 are found in a wide variety of
human leukemias but are particularly common in childhood acute lymphoblastic leukemia.
The genes involved in these rearrangements, however, have not been identified. We now ...
human leukemias but are particularly common in childhood acute lymphoblastic leukemia.
The genes involved in these rearrangements, however, have not been identified. We now ...
Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for …
…, RR Blough, HM Golomb, JD Rowley - Journal of Clinical …, 1986 - jco.ascopubs.org
Abstract Clinical, histologic, and cytogenetic features in 63 patients with a therapy-related
myelodysplastic syndrome (t-MDS) or acute nonlymphocytic leukemia (t-ANLL) following
cytotoxic chemotherapy or radiotherapy for a previous disease were analyzed. Eleven ...
myelodysplastic syndrome (t-MDS) or acute nonlymphocytic leukemia (t-ANLL) following
cytotoxic chemotherapy or radiotherapy for a previous disease were analyzed. Eleven ...
[引用] Onco gen: Human oncogene locations and chromosome aberrations
JD Rowley - 1983 - nature.com
... 5. Rowley, JD Ann. Genet. 16, 109 (1973). | PubMed | ISI | ChemPort |. ... | PubMed | ISI | ChemPort |.
7. Rowley, JD Nature 243, 290 (1973). | PubMed | ISI | ChemPort |. 8. De Martinville, B., Giacollone,
J., Francke, U., Shih, C. & Weinburg, RA Science (in the press). ...
7. Rowley, JD Nature 243, 290 (1973). | PubMed | ISI | ChemPort |. 8. De Martinville, B., Giacollone,
J., Francke, U., Shih, C. & Weinburg, RA Science (in the press). ...
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
…, SD Smith, MM LeBeau, JD Rowley - Proceedings of the …, 1991 - National Acad Sciences
Abstract Recurring chromosomal translocations involving chromosome 11, band q23, have
been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We
recently showed that breakpoints in four 11q23 translocations, t (4; 11)(q21; q23), t (6; 11)( ...
been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We
recently showed that breakpoints in four 11q23 translocations, t (4; 11)(q21; q23), t (6; 11)( ...
Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia: a unique cytogenetic–clinicopathological …
…, JW Vardiman, HM Golomb, JD Rowley - … England Journal of …, 1983 - Mass Medical Soc
Abstract We identified 18 patients with an inversion of chromosome 16, inv (16)(p13q22),
among 308 patients with newly diagnosed acute nonlymphocytic leukemia. Each of these 18
patients had acute myelomonocytic leukemia (M4 subtype) and eosinophils with distinctly ...
among 308 patients with newly diagnosed acute nonlymphocytic leukemia. Each of these 18
patients had acute myelomonocytic leukemia (M4 subtype) and eosinophils with distinctly ...
Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease
JD Rowley, HM Golomb, JW Vardiman - Blood, 1981 - bloodjournal.hematologylibrary.org
Abstract Cytogenetic studies were performed on 26 patients who developed acute
nonlymphocytic leukemia (ANLL) or a dysmyelopoietic syndrome after treatment of a primary
malignancy. Fifteen patients had radiotherapy and chemotherapy, seven had only ...
nonlymphocytic leukemia (ANLL) or a dysmyelopoietic syndrome after treatment of a primary
malignancy. Fifteen patients had radiotherapy and chemotherapy, seven had only ...
Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations
…, MM Le Beau, MO Diaz, JD Rowley - … England Journal of …, 1993 - Mass Medical Soc
Background Translocations involving chromosome band 11q23 are very frequent in both
acute lymphoblastic and acute myeloid leukemias and are the most common genetic
alteration in infants with leukemia. In all age groups and all phenotypes of leukemia, an ...
acute lymphoblastic and acute myeloid leukemias and are the most common genetic
alteration in infants with leukemia. In all age groups and all phenotypes of leukemia, an ...
The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant …
J Pedersen-Bjergaard, JD Rowley - Blood, 1994 - bloodjournal.hematologylibrary.org
Abstract Two general types of clonal chromosome abnormality are observed in de novo
acute myeloid leukemia (AML): the unbalanced aberrations with visible gain or loss of
chromosome material and the balanced aberrations without such visible gain or loss. AML ...
acute myeloid leukemia (AML): the unbalanced aberrations with visible gain or loss of
chromosome material and the balanced aberrations without such visible gain or loss. AML ...
Homozygous deletion of the alpha-and beta 1-interferon genes in human leukemia and derived cell lines
…, SD Smith, RR Chilcote, JD Rowley - Proceedings of the …, 1988 - National Acad Sciences
Abstract The loss of bands p21-22 from one chromosome 9 homologue as a consequence
of a deletion of the short arm [del (9p)], unbalanced translocation, or monosomy 9 is
frequently observed in the malignant cells of patients with lymphoid neoplasias, including ...
of a deletion of the short arm [del (9p)], unbalanced translocation, or monosomy 9 is
frequently observed in the malignant cells of patients with lymphoid neoplasias, including ...
Evidence for a 15; 17 translocation in every patient with acute promyelocytic leukemia
…, AE Butler, HM Golomb, JD Rowley - The American journal of …, 1984 - Elsevier
Abstract Cytogenetic specimens were obtained from blood or bone marrow in 27 patients
with acute promyelocytic leukemia, including four with the microgranular variant. A 15; 17
translocation was identified in 21 to 100 percent of metaphase cells from all 27 patients. ...
with acute promyelocytic leukemia, including four with the microgranular variant. A 15; 17
translocation was identified in 21 to 100 percent of metaphase cells from all 27 patients. ...
Identification of the constant chromosome regions involved in human hematologic malignant disease
JD Rowley - Science, 1982 - sciencemag.org
Abstract Specific consistent chromosome translocations are regularly observed in certain
human leukemias and lymphomas. For the myeloid leukemias, the constant recombinants
are: the long arm of 9 to chromosome 22 in chronic myeloid leukemia, the long arm of 21 ...
human leukemias and lymphomas. For the myeloid leukemias, the constant recombinants
are: the long arm of 9 to chromosome 22 in chronic myeloid leukemia, the long arm of 21 ...
The critical role of chromosome translocations in human leukemias
JD Rowley - Annual review of genetics, 1998 - annualreviews.org
▪ Abstract Many chromosome abnormalities, especially translocations or inversions, are
closely associated with a particular morphologic or phenotypic subtype of leukemia,
lymphoma, or sarcoma. Cloning the genes at the breakpoints of these rearrangements ...
closely associated with a particular morphologic or phenotypic subtype of leukemia,
lymphoma, or sarcoma. Cloning the genes at the breakpoints of these rearrangements ...
[PDF] Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping
T Veldman, C Vignon, E Schroeck, JD Rowley… - Nature …, 1997 - 198.74.230.230
Cytogenetic analysis provides critical information of diagnostic and prognostic importance
for haematological malignancies “. In fact, the identification of recurring chromosomal
breakpoints in leukaemias and lymphomas has expedited the cloning of genes whose ...
for haematological malignancies “. In fact, the identification of recurring chromosomal
breakpoints in leukaemias and lymphomas has expedited the cloning of genes whose ...
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with at (11; 16)(q23; p13. 3)
…, D Housman, NA Doggett, JD Rowley… - Proceedings of the …, 1997 - National Acad Sciences
Abstract The recurring translocation t (11; 16)(q23; p13. 3) has been documented only in
cases of acute leukemia or myelodysplasia secondary to therapy with drugs targeting DNA
topoisomerase II. We show that the MLL gene is fused to the gene that codes for CBP ( ...
cases of acute leukemia or myelodysplasia secondary to therapy with drugs targeting DNA
topoisomerase II. We show that the MLL gene is fused to the gene that codes for CBP ( ...
Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series
…, J Anastasi, JW Vardiman, JD Rowley… - …, 2003 - bloodjournal.hematologylibrary.org
Abstract Therapy-related myelodysplasia and myeloid leukemia (t-MDS/t-AML) is a
distinctive clinical syndrome occurring after exposure to chemotherapy (CT) or radiotherapy
(RT). We report findings on 306 consecutive patients referred to our institution with ...
distinctive clinical syndrome occurring after exposure to chemotherapy (CT) or radiotherapy
(RT). We report findings on 306 consecutive patients referred to our institution with ...
[引用] AML1 and the 8; 21 and 3; 21 translocations in acute and chronic myeloid leukemia
G Nucifora, JD Rowley - Blood, 1995 - bloodjournal.hematologylibrary.org
A CUTE MYELOGENOUS leukemia (AML) is one of the most frequent hematopoietic
malignancies and accounts for 46% of all major leukemias in the United States. This disease
is characterized by the proliferation of a malignant clone, resulting in the production of ...
malignancies and accounts for 46% of all major leukemias in the United States. This disease
is characterized by the proliferation of a malignant clone, resulting in the production of ...
Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
…, S Borgers, SL Smith, JD Rowley - Proceedings of the …, 2000 - National Acad Sciences
Abstract Chromosomal translocations involving the MLL gene occur in about 80% of infant
leukemia. In the search for possible agents inducing infant leukemia, we identified
bioflavonoids, natural substances in food as well as in dietary supplements, that cause ...
leukemia. In the search for possible agents inducing infant leukemia, we identified
bioflavonoids, natural substances in food as well as in dietary supplements, that cause ...
[引用] Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.
JD Rowley - Annales de genetique, 1973 - ncbi.nlm.nih.gov
1. Ann Genet. 1973 Jun;16(2):109-12. Identificaton of a translocation with quinacrine
fluorescence in a patient with acute leukemia. Rowley JD. PMID: 4125056 [PubMed -
indexed for MEDLINE]. MeSH Terms. Adult; Chromosome ...
fluorescence in a patient with acute leukemia. Rowley JD. PMID: 4125056 [PubMed -
indexed for MEDLINE]. MeSH Terms. Adult; Chromosome ...
Chromosomal banding patterns in acute nonlymphocytic leukemia
JD Rowley, D Potter - Blood, 1976 - bloodjournal.hematologylibrary.org
Abstract Bone marrow chromosomes obtained from 50 of 55 consecutive adult patients with
acute nonlymphocytic leukemia were analyzed with quinacrine fluorescence. Twenty-five
patients showed a normal karyotype and 25 an abnormal karyotype on the initial samples ...
acute nonlymphocytic leukemia were analyzed with quinacrine fluorescence. Twenty-five
patients showed a normal karyotype and 25 an abnormal karyotype on the initial samples ...
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia.
…, J McLaughlin, SK Bohlander, JD Rowley… - … and Cellular Biology, 1996 - Am Soc Microbiol
ABSTRACT TEL is a member of the Ets family of transcription factors which are frequently
rearranged in human leukemia. The mechanism of TEL-mediated transformation, however,
is unknown. We report the cloning and characterization of a chromosomal translocation ...
rearranged in human leukemia. The mechanism of TEL-mediated transformation, however,
is unknown. We report the cloning and characterization of a chromosomal translocation ...
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