小柯机器人

德国柏林夏里特医学院Andreas Horn等研究人员合作利用深部脑刺激绘制额叶皮层功能障碍回路图谱。该项研究成果于2024年2月22日在线发表在《自然—神经科学》杂志上。

研究人员测试了为治疗四种不同脑部疾病而植入的534个深部脑刺激电极。通过分析在这些疾病中哪些连接被调节以达到最佳治疗效果，研究人员将额叶皮层划分为在每种疾病中功能失调的回路。功能障碍回路从枕部到额部按地形排列，从肌张力障碍的感觉运动皮层、图雷特综合症的初级运动皮层、帕金森病的辅助运动区到强迫症的腹外侧前额叶和前扣带回皮层都有。

这些研究结果凸显了脑深部刺激与脑连接组学的结合是探索人脑结构与功能障碍之间耦合关系的有力工具。

据介绍，额叶电路在运动、认知和情感处理过程中起着至关重要的作用，其功能障碍可能导致各种脑部疾病。然而，究竟是哪些额叶区域介导了哪些（功能障碍）功能在很大程度上仍然难以确定。

附：英文原文

Title: Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation

Author: Hollunder, Barbara, Ostrem, Jill L., Sahin, Ilkem Aysu, Rajamani, Nanditha, Oxenford, Simn, Butenko, Konstantin, Neudorfer, Clemens, Reinhardt, Pablo, Zvarova, Patricia, Polosan, Mircea, Akram, Harith, Vissani, Matteo, Zhang, Chencheng, Sun, Bomin, Navratil, Pavel, Reich, Martin M., Volkmann, Jens, Yeh, Fang-Cheng, Baldermann, Juan Carlos, Dembek, Till A., Visser-Vandewalle, Veerle, Alho, Eduardo Joaquim Lopes, Franceschini, Paulo Roberto, Nanda, Pranav, Finke, Carsten, Khn, Andrea A., Dougherty, Darin D., Richardson, R. Mark, Bergman, Hagai, DeLong, Mahlon R., Mazzoni, Alberto, Romito, Luigi M., Tyagi, Himanshu, Zrinzo, Ludvic, Joyce, Eileen M., Chabardes, Stephan, Starr, Philip A., Li, Ningfei, Horn, Andreas

Issue&Volume: 2024-02-22

Abstract: Frontal circuits play a critical role in motor, cognitive and affective processing, and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)functions remains largely elusive. We studied 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregated the frontal cortex into circuits that had become dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to frontal, ranging from interconnections with sensorimotor cortices in dystonia, the primary motor cortex in Tourette’s syndrome, the supplementary motor area in Parkinson’s disease, to ventromedial prefrontal and anterior cingulate cortices in obsessive-compulsive disorder. Our findings highlight the integration of deep brain stimulation with brain connectomics as a powerful tool to explore couplings between brain structure and functional impairments in the human brain.

DOI: 10.1038/s41593-024-01570-1

Source: https://www.nature.com/articles/s41593-024-01570-1

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex