小柯机器人

美国达特茅斯学院Caroline E. Robertson研究组揭示，视黄嘌呤编码构建了感知和记忆系统之间的相互作用。该项研究成果发表在2024年1月2日出版的《自然—神经科学》上。

他们报告了视网膜位编码结构内部导向(助记)和外部导向(感知)大脑区域之间的相互作用。利用功能性磁共振成像技术，他们观察到皮层顶端类别选择性记忆区域的反向(负)视网膜位编码，这在功能上与高级视觉皮层类别选择性知觉区域的经典(正)视网膜位编码相关联。

在记忆和感知区域，这些功能相关的视网膜移植群体在自下而上的感知和自上而下的回忆中，都表现出空间特异性的相反反应，这表明这些区域在相互抑制的动态中是连锁的。这些结果表明，视网膜位编码结构感知和记忆神经系统之间的相互作用，为它们的动态相互作用提供了一个框架。

据介绍，大脑组织的传统观点认为，在皮层层次的顶部区域处理内部导向的信息使用抽象的模态神经代码。尽管如此，最近的报道已经描述了在皮质顶端存在视网膜异位编码，包括默认模式网络。在皮层层级之上的视网膜异位编码的功能角色是什么仍然未知。

附：英文原文

Title: A retinotopic code structures the interaction between perception and memory systems

Author: Steel, Adam, Silson, Edward H., Garcia, Brenda D., Robertson, Caroline E.

Issue&Volume: 2024-01-02

Abstract: Conventional views of brain organization suggest that regions at the top of the cortical hierarchy processes internally oriented information using an abstract amodal neural code. Despite this, recent reports have described the presence of retinotopic coding at the cortical apex, including the default mode network. What is the functional role of retinotopic coding atop the cortical hierarchy Here we report that retinotopic coding structures interactions between internally oriented (mnemonic) and externally oriented (perceptual) brain areas. Using functional magnetic resonance imaging, we observed robust inverted (negative) retinotopic coding in category-selective memory areas at the cortical apex, which is functionally linked to the classic (positive) retinotopic coding in category-selective perceptual areas in high-level visual cortex. These functionally linked retinotopic populations in mnemonic and perceptual areas exhibit spatially specific opponent responses during both bottom-up perception and top-down recall, suggesting that these areas are interlocked in a mutually inhibitory dynamic. These results show that retinotopic coding structures interactions between perceptual and mnemonic neural systems, providing a scaffold for their dynamic interaction.

DOI: 10.1038/s41593-023-01512-3

Source: https://www.nature.com/articles/s41593-023-01512-3

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex