小柯机器人

美国爱荷华大学Deniz Atasoy团队近期取得重要工作进展，他们研究发现，AgRP神经元能够编码昼夜节律进食时间。相关研究成果2023年11月13日在线发表于《自然—神经科学》杂志上。

据介绍，食物摄入遵循可预测的日常模式，并与代谢节奏同步。表达AgRP的神经元识别生理能量状态并引发进食，但这些神经元在日常时间尺度上的调节尚不清楚。

结合小鼠的神经元动力学测量和定时光遗传学激活，研究人员 发现每日AgRP神经元活性与现有的稳态调节模型并不完全一致。AgRP神经元的活动主要遵循昼夜节律的休息-活动周期，而不是作为“剥夺计数器”进行操作，这一过程需要完整的视交叉上核和光同步。通过限时食物获取或周期性的AgRP神经元刺激来施加新的进食模式，足以使AgRP神经元的日常活动节奏重新同步，并通过DMH^PDYN神经元驱动类似预期的行为。

总之，这些结果表明，AgRP神经元将过去进食经验的时间信息与当前代谢需求相结合，以预测昼夜进食时间。

附：英文原文

Title: AgRP neurons encode circadian feeding time

Author: Sayar-Atasoy, Nilufer, Aklan, Iltan, Yavuz, Yavuz, Laule, Connor, Kim, Hyojin, Rysted, Jacob, Alp, Muhammed Ikbal, Davis, Debbie, Yilmaz, Bayram, Atasoy, Deniz

Issue&Volume: 2023-11-13

Abstract: Food intake follows a predictable daily pattern and synchronizes metabolic rhythms. Neurons expressing agouti-related protein (AgRP) read out physiological energetic state and elicit feeding, but the regulation of these neurons across daily timescales is poorly understood. Using a combination of neuron dynamics measurements and timed optogenetic activation in mice, we show that daily AgRP-neuron activity was not fully consistent with existing models of homeostatic regulation. Instead of operating as a ‘deprivation counter’, AgRP-neuron activity primarily followed the circadian rest–activity cycle through a process that required an intact suprachiasmatic nucleus and synchronization by light. Imposing novel feeding patterns through time-restricted food access or periodic AgRP-neuron stimulation was sufficient to resynchronize the daily AgRP-neuron activity rhythm and drive anticipatory-like behavior through a process that required DMHPDYN neurons. These results indicate that AgRP neurons integrate time-of-day information of past feeding experience with current metabolic needs to predict circadian feeding time.

DOI: 10.1038/s41593-023-01482-6

Source: https://www.nature.com/articles/s41593-023-01482-6

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex