小柯机器人

美国纽约大学医学院Dayu Lin、Julieta E. Lischinsky研究团队发现，转录调控的杏仁核亚群在先天社会行为中发挥不同的功能。相关论文发表在2023年11月9日出版的《自然-神经科学》杂志上。

研究人员发现，来源于两个胚胎发育系谱的内侧杏仁核（MeA）细胞，在雄性小鼠的社会行为中具有不同的反应模式和功能。表达转录因子Foxp2（MeAFoxp2）的内侧杏仁核细胞专门处理与雄性有关的信息，对成年雄性间的攻击行为至关重要。相比之下，来自Dbx1系的MeA细胞（MeADbx1）对社交信息反应广泛，在射精时反应强烈，而且对雄性攻击行为不重要。

此外，MeAFoxp2和MeADbx1细胞具有不同的解剖和功能连接。总之，该研究结果表明，在MeA水平上存在一个发育硬连线的攻击性回路，以及一个基于品系的回路组织，细胞的胚胎转录因子特征决定了其成年期的社会信息表征和相关行为。

研究人员表示，社交行为是与生俱来的，并由专门的神经回路调控，但仍不清楚这些回路的分子特性以及它们是如何在发育过程中建立并受经验塑造。

附：英文原文

Title: Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors

Author: Lischinsky, Julieta E., Yin, Luping, Shi, Chenxi, Prakash, Nandkishore, Burke, Jared, Shekaran, Govind, Grba, Maria, Corbin, Joshua G., Lin, Dayu

Issue&Volume: 2023-11-09

Abstract: Social behaviors are innate and supported by dedicated neural circuits, but the molecular identities of these circuits and how they are established developmentally and shaped by experience remain unclear. Here we show that medial amygdala (MeA) cells originating from two embryonically parcellated developmental lineages have distinct response patterns and functions in social behavior in male mice. MeA cells expressing the transcription factor Foxp2 (MeAFoxp2) are specialized for processing male conspecific cues and are essential for adult inter-male aggression. By contrast, MeA cells derived from the Dbx1 lineage (MeADbx1) respond broadly to social cues, respond strongly during ejaculation and are not essential for male aggression. Furthermore, MeAFoxp2 and MeADbx1 cells show differential anatomical and functional connectivity. Altogether, our results suggest a developmentally hardwired aggression circuit at the MeA level and a lineage-based circuit organization by which a cell’s embryonic transcription factor profile determines its social information representation and behavioral relevance during adulthood. The authors describe the connectivity, response profile and behavioral roles of two transcriptionally defined amygdala populations from separate embryonic lineages and show how responses of one population change with social experience.

DOI: 10.1038/s41593-023-01475-5

Source: https://www.nature.com/articles/s41593-023-01475-5

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex