小柯机器人

中国科学院动物研究所刘光慧等研究人员合作以单细胞分辨率解码衰老依赖性组织再生衰退。相关论文于2023年10月27日在线发表在《细胞—干细胞》杂志上。

为了解读衰老与再生能力之间的关系，研究人员对来自年轻和衰老小鼠的八个组织的再生进行了全面的单细胞转录组分析。研究人员采用了多种分析模型来研究组织再生，并揭示了衰老组织再生过程减弱的复杂细胞和分子机制。具体来说，研究人员发现干细胞流动性受损和血管生成不足是造成与年龄相关的再生能力下降的主要原因。

此外，研究人员还发现了一个独特的Arg1⁺巨噬细胞亚群，它们在年轻组织中被激活，但在衰老再生组织中却被抑制，这表明它们在再生过程中与年龄相关的免疫反应差异中发挥着重要作用。这项研究提供了一个全面的单细胞资源，可用于确定潜在的干预目标，以提高老龄人口的再生效果。

据悉，各个组织和器官的再生能力差异很大，并随着年龄的增长而逐渐下降。

附：英文原文

Title: Decoding aging-dependent regenerative decline across tissues at single-cell resolution

Author: Yusheng Cai, Muzhao Xiong, Zijuan Xin, Chengyu Liu, Jie Ren, Xiying Yang, Jinghui Lei, Wei Li, Feifei Liu, Qun Chu, Yiyuan Zhang, Jian Yin, Yanxia Ye, Dingyi Liu, Yanling Fan, Shuhui Sun, Yaobin Jing, Qian Zhao, Liyun Zhao, Shanshan Che, Yandong Zheng, Haoteng Yan, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu

Issue&Volume: 2023-10-27

Abstract: Regeneration across tissues and organs exhibits significant variation throughout thebody and undergoes a progressive decline with age. To decode the relationships betweenaging and regenerative capacity, we conducted a comprehensive single-cell transcriptomeanalysis of regeneration in eight tissues from young and aged mice. We employed diverseanalytical models to study tissue regeneration and unveiled the intricate cellularand molecular mechanisms underlying the attenuated regenerative processes observedin aged tissues. Specifically, we identified compromised stem cell mobility and inadequateangiogenesis as prominent contributors to this age-associated decline in regenerativecapacity. Moreover, we discovered a unique subset of Arg1+ macrophages that were activated in young tissues but suppressed in aged regeneratingtissues, suggesting their important role in age-related immune response disparitiesduring regeneration. This study provides a comprehensive single-cell resource foridentifying potential targets for interventions aimed at enhancing regenerative outcomesin the aging population.

DOI: 10.1016/j.stem.2023.09.014

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00361-2

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
官方网址：https://www.cell.com/cell-stem-cell/home
投稿链接：https://www.editorialmanager.com/cell-stem-cell/default.aspx