小柯机器人

华中农业大学Maojun Wang，Xianlong Zhang和Lili Tu共同合作，近期取得重要工作进展。他们研究提出了异源四倍体棉花纤维发育过程中重复基因表达的调控动力学。这一研究成果2023年10月16日在线发表于《自然—遗传学》杂志上。

据介绍，多倍体使转录调控复杂化，并增加生物体的表型多样性。多倍体中的共同亚基因组之间基因表达的遗传调控动力学仍有待了解。

研究人员通过对376个基因组和2215个时间序列转录组的测序，记录了异四倍体棉纤维发育的遗传调控。研究人员对1258个基因进行了表征，这些基因包括36个控制阶段性纤维发育的遗传模块，并揭示了控制其相对于亚基因组重复基因（同源性）的分区表达的遗传成分。只有大约30%的纤维品质相关同源性在品种中表现出表型上有利的等位基因聚集，这突出了亚基因组可加性在纤维改良中的潜力。研究人员设想了一种基因组育种策略，特别关注与纤维表型相关的48个有利等位基因，这些等位基因在驯化过程中经过纯化选择。

总之，这一工作描述了纤维发育过程中基因调控的动态，并强调了亚基因组协调支持多倍体植物表型的潜力。

附：英文原文

Title: Regulatory controls of duplicated gene expression during fiber development in allotetraploid cotton

Author: You, Jiaqi, Liu, Zhenping, Qi, Zhengyang, Ma, Yizan, Sun, Mengling, Su, Ling, Niu, Hao, Peng, Yabing, Luo, Xuanxuan, Zhu, Mengmeng, Huang, Yuefan, Chang, Xing, Hu, Xiubao, Zhang, Yuqi, Pi, Ruizhen, Liu, Yuqi, Meng, Qingying, Li, Jianying, Zhang, Qinghua, Zhu, Longfu, Lin, Zhongxu, Min, Ling, Yuan, Daojun, Grover, Corrinne E., Fang, David D., Lindsey, Keith, Wendel, Jonathan F., Tu, Lili, Zhang, Xianlong, Wang, Maojun

Issue&Volume: 2023-10-16

Abstract: Polyploidy complicates transcriptional regulation and increases phenotypic diversity in organisms. The dynamics of genetic regulation of gene expression between coresident subgenomes in polyploids remains to be understood. Here we document the genetic regulation of fiber development in allotetraploid cotton Gossypium hirsutum by sequencing 376 genomes and 2,215 time-series transcriptomes. We characterize 1,258 genes comprising 36 genetic modules that control staged fiber development and uncover genetic components governing their partitioned expression relative to subgenomic duplicated genes (homoeologs). Only about 30% of fiber quality-related homoeologs show phenotypically favorable allele aggregation in cultivars, highlighting the potential for subgenome additivity in fiber improvement. We envision a genome-enabled breeding strategy, with particular attention to 48 favorable alleles related to fiber phenotypes that have been subjected to purifying selection during domestication. Our work delineates the dynamics of gene regulation during fiber development and highlights the potential of subgenomic coordination underpinning phenotypes in polyploid plants.

DOI: 10.1038/s41588-023-01530-8

Source: https://www.nature.com/articles/s41588-023-01530-8

Nature Genetics：《自然—遗传学》，创刊于1992年。隶属于施普林格·自然出版集团，最新IF：41.307
官方网址：https://www.nature.com/ng/
投稿链接：https://mts-ng.nature.com/cgi-bin/main.plex