小柯机器人

2023年9月8日，美国西北大学John A. Rogers研究组在《科学》杂志发表论文。该研究开发出用于早期检测肾移植排斥反应的植入式生物电子系统。

研究人员开发了一种植入式生物电子系统，能够连续、实时、长期监测肾脏的局部温度和热导率，用于检测与移植物排斥相关的炎症过程。该系统能检测到短昼夜节律、昼夜周期紊乱和/或肾脏温度升高。这些都是急性肾移植排斥反应的预警信号，在停止使用和未使用免疫抑制疗法的情况下，这些信号分别比血清肌酐/尿素氮的变化早2到3周和大约3天。

据悉，早期器官移植排斥反应很难检测。经皮活检并不常见，而且风险很大，测量血液中的生物标记物水平可能导致假阴性和假阳性结果。

附：英文原文

Title: Implantable bioelectronic systems for early detection of kidney transplant rejection

Author: Surabhi R. Madhvapathy, Jiao-Jing Wang, Heling Wang, Manish Patel, Anthony Chang, Xin Zheng, Yonggang Huang, Zheng J. Zhang, Lorenzo Gallon, John A. Rogers

Issue&Volume: 2023-09-08

Abstract: Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur infrequently and are risky, and measuring biomarker levels in blood can lead to false-negative and -positive outcomes. We developed an implantable bioelectronic system capable of continuous, real-time, long-term monitoring of the local temperature and thermal conductivity of a kidney for detecting inflammatory processes associated with graft rejection, as demonstrated in rat models. The system detects ultradian rhythms, disruption of the circadian cycle, and/or a rise in kidney temperature. These provide warning signs of acute kidney transplant rejection that precede changes in blood serum creatinine/urea nitrogen by 2 to 3 weeks and approximately 3 days for cases of discontinued and absent administration of immunosuppressive therapy, respectively.

DOI: adh7726

Source: https://www.science.org/doi/full/10.1126/science.adh7726