小柯机器人

香港中文大学Jun Yu、William Ka Kei Wu和Matthew Tak Vai Chan课题组合作取得一项新成果。经过不懈努力，他们发现了麦芽香肉杆菌通过促进肠道维生素D的产生抑制雌性小鼠的结直肠癌(CRC)。这一研究成果于2023年7月20日发表在国际学术期刊《癌细胞》上。

在女性结直肠癌患者体内存在麦芽香肉杆菌特异性缺失。在两种雌性小鼠CRC模型中回补麦芽香肉杆菌会特异性减少肠道肿瘤的形成。雌激素通过增加结肠中与麦芽香肉杆菌DD-CPase结合的SLC3A2来增加麦芽香肉杆菌的附着和定植。代谢组学和转录组学分析表明，维生素D相关代谢物肠道丰度的增加和麦芽香肉杆菌定植小鼠中粘膜维生素D受体（VDR）信号传导的活化依赖于肠道微生物组和VDR。

体外发酵系统证明麦芽香肉杆菌与粪杆菌的代谢存在交叉，粪杆菌将麦芽香肉杆菌产生的7-脱氢胆固醇转化为维生素D，以激活宿主VDR信号传导。总体而言，麦芽香肉杆菌以雌激素依赖的方式定植在肠道中，并与其他微生物一起增加肠道维生素D的产生，通过激活宿主VDR抑制CRC。

附：英文原文

Title: Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice

Author: Qing Li, Hung Chan, Wei-Xin Liu, Chang-An Liu, Yunfei Zhou, Dan Huang, Xueliang Wang, Xiaoxing Li, Chuan Xie, Wing Ying-Zhi Liu, Xian-Song Wang, Siu Kin Ng, Hongyan Gou, Liu-Yang Zhao, Winnie Fong, Lanping Jiang, Yufeng Lin, Guijun Zhao, Feihu Bai, Xiaodong Liu, Huarong Chen, Lin Zhang, Sunny Hei Wong, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu

Issue&Volume: 2023-07-20

Abstract: Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor formation in two murine CRC models in a female-specific manner. Estrogen increases the attachment and colonization of C. maltaromaticum via increasing the colonic expression of SLC3A2 that binds to DD-CPase of this bacterium. Metabolomic and transcriptomic profiling unveils the increased gut abundance of vitamin D-related metabolites and the mucosal activation of vitamin D receptor (VDR) signaling in C. maltaromaticum-gavaged mice in a gut microbiome- and VDR-dependent manner. In vitro fermentation system confirms the metabolic cross-feeding of C. maltaromaticum with Faecalibacterium prausnitzii to convert C. maltaromaticum-produced 7-dehydrocholesterol into vitamin D for activating the host VDR signaling. Overall, C. maltaromaticum colonizes the gut in an estrogen-dependent manner and acts along with other microbes to augment the intestinal vitamin D production to activate the host VDR for suppressing CRC.

DOI: 10.1016/j.ccell.2023.06.011

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00236-2

Cancer Cell：《癌细胞》，创刊于2002年。隶属于细胞出版社，最新IF：38.585
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