小柯机器人

德国欧洲分子生物学实验室Miki Ebisuya等研究人员合作表明，一个干细胞“动物园”发现不同哺乳动物发育节奏的细胞内比例。2023年6月20日，《细胞—干细胞》杂志在线发表了这项成果。

利用多能干细胞的体外分化，研究人员重现了不同体重和分类群的哺乳动物物种的体节时钟：狨猴、兔、牛和犀牛。与小鼠和人类一样，这6个物种的分节钟周期不随动物体重的变化而变化，而是随胚胎发育的长度变化。核心时钟基因HES7的生化动力学显示出与特定物种的体节时钟周期有明显的比例关系。然而，细胞代谢率并没有显示出明显的相关性。相反，涉及生化反应的基因显示出与体节时钟周期成比例的表达模式。

总的来说，这个干细胞动物园发现了管理物种特定发育节奏的通用比例定律。

据介绍，有人提出，生化反应的速度不同是造成小鼠和人类之间发育节奏差异的原因。然而，控制物种特定动力学的基本机制仍有待确定。

附：英文原文

Title: A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals

Author: Jorge Lázaro, Maria Costanzo, Marina Sanaki-Matsumiya, Charles Girardot, Masafumi Hayashi, Katsuhiko Hayashi, Sebastian Diecke, Thomas B. Hildebrandt, Giovanna Lazzari, Jun Wu, Stoyan Petkov, Rüdiger Behr, Vikas Trivedi, Mitsuhiro Matsuda, Miki Ebisuya

Issue&Volume: 2023-06-20

Abstract: Differential speeds in biochemical reactions have been proposed to be responsible for the differences in developmental tempo between mice and humans. However, the underlying mechanism controlling the species-specific kinetics remains to be determined. Using in vitro differentiation of pluripotent stem cells, we recapitulated the segmentation clocks of diverse mammalian species varying in body weight and taxa: marmoset, rabbit, cattle, and rhinoceros. Together with mousee and human, the segmentation clock periods of the six species did not scale with the animal body weight, but with the embryogenesis length. The biochemical kinetics of the core clock gene HES7 displayed clear scaling with the species-specific segmentation clock period. However, the cellular metabolic rates did not show an evident correlation. Instead, genes involving biochemical reactions showed an expression pattern that scales with the segmentation clock period. Altogether, our stem cell zoo uncovered general scaling laws governing species-specific developmental tempo.

DOI: 10.1016/j.stem.2023.05.014

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00210-2

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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