美国斯坦福大学医学院教授Thomas A. Rando团队近期取得重要工作进展，他们研究发现，运动可以重新编程哺乳动物衰老过程中多个干细胞区的炎症图谱。相关研究成果2023年4月19日在线发表于《细胞—干细胞》杂志上。
据介绍，运动具有使衰老动物的干细胞恢复活力和促进组织再生的能力。然而，运动引起的细胞和分子变化尚未在干细胞区室的广泛细胞类型中进行系统研究。
研究人员对年轻和老年小鼠进行有氧运动，并生成了肌肉、神经和造血干细胞及其小生境细胞和后代的单细胞转录组图谱，并辅以对单个肌纤维的全转录组分析。研究人员发现，运动改善了许多与衰老相关的炎症途径的上调，并恢复了这些干细胞区内免疫细胞介导的细胞间通讯。运动对循环和组织内免疫细胞的组成和转录组概况有着深远的影响。
总之，这一研究在转录组水平上提供了多个衰老干细胞和小生境细胞对运动的协调反应的全面观点。
附：英文原文
Title: Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging
Author: Ling Liu, Soochi Kim, Matthew T. Buckley, Jaime M. Reyes, Jengmin Kang, Lei Tian, Mingqiang Wang, Alexander Lieu, Michelle Mao, Cristina Rodriguez-Mateo, Heather D. Ishak, Mira Jeong, Joseph C. Wu, Margaret A. Goodell, Anne Brunet, Thomas A. Rando
Issue&Volume: 2023-04-19
Abstract: Exercise has the ability to rejuvenate stem cells and improve tissue regenerationin aging animals. However, the cellular and molecular changes elicited by exercisehave not been systematically studied across a broad range of cell types in stem cellcompartments. We subjected young and old mice to aerobic exercise and generated asingle-cell transcriptomic atlas of muscle, neural, and hematopoietic stem cells withtheir niche cells and progeny, complemented by whole transcriptome analysis of singlemyofibers. We found that exercise ameliorated the upregulation of a number of inflammatorypathways associated with old age and restored aspects of intercellular communicationmediated by immune cells within these stem cell compartments. Exercise has a profoundimpact on the composition and transcriptomic landscape of circulating and tissue-residentimmune cells. Our study provides a comprehensive view of the coordinated responsesof multiple aged stem cells and niche cells to exercise at the transcriptomic level.
DOI: 10.1016/j.stem.2023.03.016
Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00087-5
Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
官方网址：https://www.cell.com/cell-stem-cell/home
投稿链接：https://www.editorialmanager.com/cell-stem-cell/default.aspx
本期文章：《细胞—干细胞》：Online/在线发表
