小柯机器人

瑞士脑-心研究所和生物工程研究所Pavan Ramdya团队近期取得重要工作进展，他们研究发现上行神经元（AN）将行为状态传递到整合感觉和行动选择大脑区域。相关研究成果2023年3月23日在线发表于《自然—神经科学》杂志上。

据介绍，长期以来，了解自己的行为状态一直被认为是将动态感觉线索情境化和识别适当的未来行为的关键。运动系统中投射到大脑的AN能够很好地提供这种行为状态信号。然而，AN编码什么以及它们在哪里传递这些信号在很大程度上仍然未知。

通过行为动物的大规模功能成像和形态学定量，研究人员报道了成年果蝇中数百种可遗传识别AN的行为编码和大脑靶向。研究人员揭示了AN编码行为状态，特别是将自我运动传递到前腹外侧原小脑（一个整合的感觉中枢），以及将离散动作传递到颚神经节（一个用于动作选择的位置）。

此外，运动系统内的AN投影模式可以预测它们的编码。因此，AN群体能够很好地通知不同的大脑中枢自我运动和正在进行的行为，并可能为适应性行为所需的计算提供重要的基础。

附：英文原文

Title: Ascending neurons convey behavioral state to integrative sensory and action selection brain regions

Author: Chen, Chin-Lin, Aymanns, Florian, Minegishi, Ryo, Matsuda, Victor D. V., Talabot, Nicolas, Gnel, Semih, Dickson, Barry J., Ramdya, Pavan

Issue&Volume: 2023-03-23

Abstract: Knowing one’s own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons (ANs) in the motor system that project to the brain are well positioned to provide such behavioral state signals. However, what ANs encode and where they convey these signals remains largely unknown. Here, through large-scale functional imaging in behaving animals and morphological quantification, we report the behavioral encoding and brain targeting of hundreds of genetically identifiable ANs in the adult fly, Drosophila melanogaster. We reveal that ANs encode behavioral states, specifically conveying self-motion to the anterior ventrolateral protocerebrum, an integrative sensory hub, as well as discrete actions to the gnathal ganglia, a locus for action selection. Additionally, AN projection patterns within the motor system are predictive of their encoding. Thus, ascending populations are well poised to inform distinct brain hubs of self-motion and ongoing behaviors and may provide an important substrate for computations that are required for adaptive behavior.

DOI: 10.1038/s41593-023-01281-z

Source: https://www.nature.com/articles/s41593-023-01281-z

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex