小柯机器人

美国德克萨斯大学西南医学中心Sean J. Morrison研究组的最新研究发现，骨髓和骨膜骨干/祖细胞（SSC）对骨骼的维护和修复有不同的功能。相关论文发表在2022年10月21日出版的《细胞-干细胞》杂志上。

研究人员发现，成人骨髓中的SSC可以根据Lepr^cre和脂联素- cre/creER的表达来鉴定，而成人骨膜中的SSC可以根据Gli1^creERT2的表达来识别。在稳态条件下，新骨主要由骨髓SSC产生。骨损伤后，两个SSC细胞群都开始增殖，但对骨修复的贡献非常不同。

相反，尽管LepR⁺/脂联素⁺骨髓细胞在骨折部位短暂形成小梁骨，但双皮质骨折主要由Gli1⁺骨膜SSC修复。LepR⁺骨髓基质细胞是由Gli1⁺骨膜细胞发育而来，这些细胞在骨折部位表达造血细胞因子。因此，不同骨损伤由不同的SSC修复，骨膜细胞在不稳定性骨折后再生为骨和骨髓基质。

据了解，骨生物学中的一个基本问题是骨髓中SSC与骨膜对骨修复的贡献。

附：英文原文

Title: Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair

Author: Elise C. Jeffery, Terry L.A. Mann, Jade A. Pool, Zhiyu Zhao, Sean J. Morrison

Issue&Volume: 2022-10-21

Abstract: A fundamental question in bone biology concerns the contributions of skeletal stem/progenitor cells (SSCs) in the bone marrow versus the periosteum to bone repair. We found that SSCs in adult bone marrow can be identified based on Leprcre and Adiponectin-cre/creER expression while SSCs in adult periosteum can be identified based on Gli1creERT2 expression. Under steady-state conditions, new bone arose primarily from bone marrow SSCs. After bone injuries, both SSC populations began proliferating but made very different contributions to bone repair. Drill injuries were primarily repaired by LepR+/Adiponectin+ bone marrow SSCs. Conversely, bicortical fractures were primarily repaired by Gli1+ periosteal SSCs, though LepR+/Adiponectin+ bone marrow cells transiently formed trabecular bone at the fracture site. Gli1+ periosteal cells also regenerated LepR+ bone marrow stromal cells that expressed hematopoietic niche factors at fracture sites. Different bone injuries are thus repaired by different SSCs, with periosteal cells regenerating bone and marrow stroma after non-stabilized fractures.

DOI: 10.1016/j.stem.2022.10.002

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00420-9

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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