美国埃默里大学Shannon L. Gourley研究组发现一个分子整合的杏仁核-额-纹状体网络协调灵活的学习和记忆。2022年8月30日在《自然—神经科学》杂志发表该论文。
他们在小鼠中证明，当熟悉的行为意外没有得到奖励时，基底外侧杏仁核 (BLA)→眶额皮质 (OFC)投射双向控制记忆形成，而OFC→背内侧纹状体 (DMS) 投射促进记忆检索。OFC 神经元集合存储新学习信息的记忆轨迹，这似乎是由特定BLA-OFC-DMS连接内的电路特异性树突棘可塑性和神经营养因子信号传导促进的，并被可卡因阻碍。因此，他们描述了跨时间的集成杏仁核-额叶-纹状体电路内信息的定向传输，其中新记忆由BLA→OFC输入编码，在 OFC 集合中表示，并在未来选择期间通过 OFC→DMS 输出检索。
据悉，行为灵活性——即偏离既定行为序列的能力——对于导航动态环境至关重要，并且需要对新记忆进行持久编码和检索以指导未来的选择。OFC支持以结果为导向的行为。然而OFC 连接维持灵活学习和记忆的协调神经回路和细胞机制仍然未知。
附：英文原文
Title: A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory
Author: Li, Dan C., Dighe, Niharika M., Barbee, Britton R., Pitts, Elizabeth G., Kochoian, Brik, Blumenthal, Sarah A., Figueroa, Janet, Leong, Traci, Gourley, Shannon L.
Issue&Volume: 2022-08-30
Abstract: Behavioral flexibility—that is, the ability to deviate from established behavioral sequences—is critical for navigating dynamic environments and requires the durable encoding and retrieval of new memories to guide future choice. The orbitofrontal cortex (OFC) supports outcome-guided behaviors. However, the coordinated neural circuitry and cellular mechanisms by which OFC connections sustain flexible learning and memory remain elusive. Here we demonstrate in mice that basolateral amygdala (BLA)→OFC projections bidirectionally control memory formation when familiar behaviors are unexpectedly not rewarded, whereas OFC→dorsomedial striatum (DMS) projections facilitate memory retrieval. OFC neuronal ensembles store a memory trace for newly learned information, which appears to be facilitated by circuit-specific dendritic spine plasticity and neurotrophin signaling within defined BLA–OFC–DMS connections and obstructed by cocaine. Thus, we describe the directional transmission of information within an integrated amygdalo-fronto-striatal circuit across time, whereby novel memories are encoded by BLA→OFC inputs, represented within OFC ensembles and retrieved via OFC→DMS outputs during future choice.
DOI: 10.1038/s41593-022-01148-9
Source: https://www.nature.com/articles/s41593-022-01148-9
Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex
本期文章：《自然—神经科学》：Online/在线发表
