小柯机器人

美国波士顿大学Robert M. G. Reinhart研究团队报道了具有重复性神经调节的老年人工作记忆和长期记忆的持续、可分离的改善。2022年8月22日，在《自然—神经科学》杂志发表了该论文。

他们描述了重复（4天）经颅交流电刺激 (tACS) 方案，用于选择性、可持续地增强65-88岁人群的听觉-语言工作记忆和长期记忆。在干预后第3天、第4天和第1个月，调节顶叶皮层同步低频而非高频活动优先改善工作记忆，而调节前额叶同步高频而非低频活动在干预后的第2-4天和第1个月，皮质优先改善长期记忆。4天的内存改进率预测了1个月后内存收益的大小。基线认知功能较低的个体经历了更大、更持久的记忆改善。

他们的研究结果表明，衰老大脑的可塑性可以通过基于记忆特定皮质回路的空间光谱参数的重复，和高度集中的神经调节来选择性和可持续地利用。

据介绍，开发保护或增强老年人记忆力的技术是转化医学的一个长期目标。

附：英文原文

Title: Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation

Author: Grover, Shrey, Wen, Wen, Viswanathan, Vighnesh, Gill, Christopher T., Reinhart, Robert M. G.

Issue&Volume: 2022-08-22

Abstract: The development of technologies to protect or enhance memory in older people is an enduring goal of translational medicine. Here we describe repetitive (4-day) transcranial alternating current stimulation (tACS) protocols for the selective, sustainable enhancement of auditory–verbal working memory and long-term memory in 65–88-year-old people. Modulation of synchronous low-frequency, but not high-frequency, activity in parietal cortex preferentially improved working memory on day 3 and day 4 and 1month after intervention, whereas modulation of synchronous high-frequency, but not low-frequency, activity in prefrontal cortex preferentially improved long-term memory on days 2–4 and 1month after intervention. The rate of memory improvements over 4days predicted the size of memory benefits 1month later. Individuals with lower baseline cognitive function experienced larger, more enduring memory improvements. Our findings demonstrate that the plasticity of the aging brain can be selectively and sustainably exploited using repetitive and highly focalized neuromodulation grounded in spatiospectral parameters of memory-specific cortical

DOI: 10.1038/s41593-022-01132-3

Source: https://www.nature.com/articles/s41593-022-01132-3

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex