小柯机器人

美国纽约大学György Buzsáki和Roman Huszár研究团队合作发现，海马体的预配置动态是由胚胎出生日期和神经发生率所引导。该项研究成果发表在2022年8月22日出版的《自然—神经科学》上。

他们表明海马网络动力学受连续神经发生的影响。他们测定了胚胎期4天内子宫电穿孔的CA1锥体神经元，包括海马神经发生的高峰，并比较了它们在自由运动的成年小鼠中的功能特征。同一出生日期的神经元显示出不同的连接性、跨大脑状态的协同性和组装动力学。相同出生日期的神经元表现出重叠的空间表征，这些表征在不同的环境中保持不变。总体而言，CA1锥体神经元的连接和功能特征反映了出生日期和神经发生率的组合。这些观察表明，胚胎发育过程中的连续神经发生塑造了成人网络动态的预配置形式。

据了解，将新信息纳入海马网络可能会受到其固有架构和内部生成的活动模式的限制。然而，这种模式的起源、组织和后果仍然知之甚少。

附：英文原文

Title: Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis

Author: Huszr, Roman, Zhang, Yunchang, Blockus, Heike, Buzski, Gyrgy

Issue&Volume: 2022-08-22

Abstract: The incorporation of new information into the hippocampal network is likely to be constrained by its innate architecture and internally generated activity patterns. However, the origin, organization and consequences of such patterns remain poorly understood. In the present study we show that hippocampal network dynamics are affected by sequential neurogenesis. We birthdated CA1 pyramidal neurons with in utero electroporation over 4 embryonic days, encompassing the peak of hippocampal neurogenesis, and compared their functional features in freely moving adult mice. Neurons of the same birthdate displayed distinct connectivity, coactivity across brain states and assembly dynamics. Same-birthdate neurons exhibited overlapping spatial representations, which were maintained across different environments. Overall, the wiring and functional features of CA1 pyramidal neurons reflected a combination of birthdate and the rate of neurogenesis. These observations demonstrate that sequential neurogenesis during embryonic development shapes the preconfigured forms of adult network dynamics.

DOI: 10.1038/s41593-022-01138-x

Source: https://www.nature.com/articles/s41593-022-01138-x

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex