小柯机器人

2022年5月24日，《细胞—干细胞》杂志在线发表了中国科学院动物研究所刘光慧等研究人员的合作成果，该研究揭示了年轻血液促进干细胞及机体年轻化的分子机制。

研究人员构建了一个单细胞转录组图谱，横跨老化的组织/器官及其在异体共生（HP）中的恢复，这是一个研究系统老化的经典模型。总的来说，HP使成体干细胞和它们在各组织的微环境恢复了活力。特别是，研究人员发现造血干细胞和祖细胞（HSPC）是对年轻血液暴露反应最强烈的细胞类型之一，通过恢复年轻的转录调控程序和细胞因子介导的细胞-细胞通讯，整个造血和免疫系统的细胞状态连续变化。此外，重新引入已确定的年轻化因素缓解了与年龄相关的淋巴组织衰退。总的来说，研究人员提供了全面的框架来探索单细胞分辨率下的老化和年轻化轨迹，并揭示了通过血源性因素指导系统性年轻化的细胞和分子程序。

据了解，年轻的循环环境能够延缓单个组织的衰老，这是人们感兴趣的年轻化策略，但它如何实现细胞和系统层面的影响仍不清楚。

附：英文原文

Title: Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues

Author: Shuai Ma, Si Wang, Yanxia Ye, Jie Ren, Ruiqing Chen, Wei Li, Jiaming Li, Liyun Zhao, Qian Zhao, Guoqiang Sun, Ying Jing, Yuesheng Zuo, Muzhao Xiong, Yuanhan Yang, Qiaoran Wang, Jinghui Lei, Shuhui Sun, Xiao Long, Moshi Song, Shuyang Yu, Piu Chan, Jianwei Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu

Issue&Volume: 2022-05-24

Abstract: The young circulatory milieu capable of delaying aging in individual tissues is ofinterest as rejuvenation strategies, but how it achieves cellular- and systemic-leveleffects has remained unclear. Here, we constructed a single-cell transcriptomic atlasacross aged tissues/organs and their rejuvenation in heterochronic parabiosis (HP),a classical model to study systemic aging. In general, HP rejuvenated adult stem cellsand their niches across tissues. In particular, we identified hematopoietic stem andprogenitor cells (HSPCs) as one of the most responsive cell types to young blood exposure,from which a continuum of cell state changes across the hematopoietic and immune systememanated, through the restoration of a youthful transcriptional regulatory programand cytokine-mediated cell-cell communications in HSPCs. Moreover, the reintroductionof the identified rejuvenating factors alleviated age-associated lymphopoiesis decline.Overall, we provide comprehensive frameworks to explore aging and rejuvenating trajectoriesat single-cell resolution and revealed cellular and molecular programs that instructsystemic revitalization by blood-borne factors.

DOI: 10.1016/j.stem.2022.04.017

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00170-9

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
官方网址：https://www.cell.com/cell-stem-cell/home
投稿链接：https://www.editorialmanager.com/cell-stem-cell/default.aspx