小柯机器人

上海大学魏滨团队与中国科学院分子细胞科学卓越创新中心王红艳团队合作发现，脑膜淋巴管介导中枢神经系统的神经性病毒排泄。2022年5月6日出版的《自然—神经科学》杂志发表了这项成果。

据研究人员介绍，最近的研究表明，脑膜淋巴管（MLV）作为脑脊液（CSF）中含有的大分子直接进入颈部淋巴结（CLN）的排泄途径。然而，在中枢神经系统病毒感染期间，MLV的作用仍未被探究。

研究人员发现，小鼠感染几种神经性病毒会促进MLV的扩张，但也会导致MLV介导的大分子排泄受损。值得注意的是，MLV可以将病毒从中枢神经系统排到CLN。淋巴管的手术结扎或背侧MLV的光动力敲除增加了病毒感染小鼠的神经系统损伤和死亡率。相比之下，用血管内皮生长因子C预处理促进了功能性MLV的扩张，并减轻了病毒感染的影响。这些数据共同表明，功能性MLV促进了病毒的清除，而且MLV是病毒从中枢神经系统扩散到CLN的关键路径。因此，基于MLV的治疗策略可能有助于减轻感染引起的神经系统损伤。

附：英文原文

Title: Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system

Author: Li, Xiaojing, Qi, Linlin, Yang, Dan, Hao, ShuJie, Zhang, Fang, Zhu, Xingguo, Sun, Yue, Chen, Chen, Ye, Jing, Yang, Jing, Zhao, Ling, Altmann, Daniel M., Cao, Shengbo, Wang, Hongyan, Wei, Bin

Issue&Volume: 2022-05-06

Abstract: Recent studies have demonstrated that brain meningeal lymphatic vessels (MLVs) act as a drainage path directly into the cervical lymph nodes (CLNs) for macromolecules contained in the cerebrospinal fluid (CSF). However, the role of MLVs during CNS viral infection remains unexplored. Here, we found that infection with several neurotropic viruses in mice promotes MLV expansion but also causes impaired MLV-mediated drainage of macromolecules. Notably, MLVs could drain virus from the CNS to CLNs. Surgical ligation of the lymph vessels or photodynamic ablation of dorsal MLVs increased neurological damage and mortality of virus-infected mice. By contrast, pretreatment with vascular endothelial growth factor C promoted expansion of functional MLVs and alleviated the effects of viral infection. Together, these data indicate that functional MLVs facilitate virus clearance, and MLVs represent a critical path for virus spreading from the CNS to the CLNs. MLV-based therapeutic strategies may thus be useful for alleviating infection-induced neurological damage. This study finds that during acute viral infection of the CNS, meningeal lymphatic vessels (MLVs) can transport virus from the CNS to draining cervical lymph nodes. VEGF-C-induced expansion of functional MLVs facilitated virus clearance.

DOI: 10.1038/s41593-022-01063-z

Source: https://www.nature.com/articles/s41593-022-01063-z

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex