小柯机器人

英国剑桥大学Peter J. Rugg-Gunn等研究人员合作发现，灵长类动物中的羊膜发生具有两个独立的阶段。2022年4月18日，国际知名学术期刊《细胞—干细胞》在线发表了这一成果。

据研究人员介绍，在灵长类动物中，羊膜在植入过程中通过外胚层的空腔化而出现，而在其他物种中，羊膜是在原肠运动后期通过外胚层的折叠而出现的。在进化过程中，羊膜形成的机制如何多样化仍是未知数。出乎意料的是，对灵长类动物胚胎的单细胞分析发现了两个转录和时间上不同的羊膜形成波。

Title: Amniogenesis occurs in two independent waves in primates

Author: Maria Rostovskaya, Simon Andrews, Wolf Reik, Peter J. Rugg-Gunn

Issue&Volume: 2022-04-18

Abstract: In primates, the amnion emerges through cavitation of the epiblast during implantation, whereas in other species it does so later at gastrulation by the folding of the ectoderm. How the mechanisms of amniogenesis diversified during evolution remains unknown. Unexpectedly, single-cell analysis of primate embryos uncovered two transcriptionally and temporally distinct amniogenesis waves. To study this, we employed the naive-to-primed transition of human pluripotent stem cells (hPSCs) to model peri-implantation epiblast development. Partially primed hPSCs transiently gained the ability to differentiate into cavitating epithelium that transcriptionally and morphologically matched the early amnion, whereas fully primed hPSCs produced cells resembling the late amnion instead, thus recapitulating the two independent differentiation waves. The early wave follows a trophectoderm-like pathway and encompasses cavitation, whereas the late wave resembles an ectoderm-like route during gastrulation. The discovery of two independent waves explains how amniogenesis through cavitation could emerge during evolution via duplication of the pre-existing trophectoderm program.

DOI: 10.1016/j.stem.2022.03.014

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00112-6

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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