小柯机器人

近日，美国爱因斯坦医学院Dachuan Zhang等研究人员发现，微生物群通过控制骨髓中的铁离子可用性来调节造血干细胞的命运决定。2022年1月21日，《细胞—干细胞》杂志在线发表了这项成果。

研究人员表明，微生物群通过调节骨髓（BM）中的局部铁供应，在压力条件下调节造血干细胞的自我更新和分化。在微生物群被剥夺的小鼠中，造血干细胞的自我更新得到加强，而分化的确立则受到极大的影响。从机制上讲，微生物群的耗竭选择性地损害了骨髓巨噬细胞对红细胞（RBC）的回收，导致局部铁水平下降，而不影响全身的铁平衡状态。限制食物（体内）或培养（体外）中的铁供应，或通过CD169⁺巨噬细胞的耗竭，增强了造血干细胞的自我更新和扩展。这些结果揭示了微生物群、巨噬细胞和铁之间错综复杂的相互作用，以及它们在调节压力下关键的造血干细胞命运决定方面的重要作用。

据了解，宿主微生物群的串联对于血细胞系的产生和功能调节至关重要。微生物群是否影响造血干细胞，以及如何影响，尚不清楚。

附：英文原文

Title: The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow

Author: Dachuan Zhang, Xin Gao, Huihui Li, Daniel K. Borger, Qiaozhi Wei, Eva Yang, Chunliang Xu, Sandra Pinho, Paul S. Frenette

Issue&Volume: 2022-01-21

Abstract: Host microbiota crosstalk is essential for the production and functional modulationof blood-cell lineages. Whether, and if so how, the microbiota influences hematopoieticstem cells (HSCs) is unclear. Here, we show that the microbiota regulates HSC self-renewaland differentiation under stress conditions by modulating local iron availabilityin the bone marrow (BM). In microbiota-depleted mice, HSC self-renewal was enhancedduring regeneration, while the commitment toward differentiation was dramaticallycompromised. Mechanistically, microbiota depletion selectively impaired the recyclingof red blood cells (RBCs) by BM macrophages, resulting in reduced local iron levelswithout affecting systemic iron homeostasis. Limiting iron availability in food (in vivo) or in culture (ex vivo), or by CD169+ macrophage depletion, enhanced HSC self-renewal and expansion. These results revealan intricate interplay between the microbiota, macrophages, and iron, and their essentialroles in regulating critical HSC fate decisions under stress.

DOI: 10.1016/j.stem.2021.12.009

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00519-1

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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