伊朗德黑兰医科大学Sakineh Shab-Bidar团队研究了人体测量值和肥胖指标与2型糖尿病风险的相关性。2022年1月18日，《英国医学杂志》在线发表了这一成果。
为了全面回顾体重、腰围和脂肪测量值以及这些测量值的不同比率与2型糖尿病风险之间的相关性，研究组针对PubMed、Scopus和科学引文索引数据库中截至2021年5月1日的相关文献，纳入关于普通成年人群中全身或中心性肥胖与体脂含量和2型糖尿病风险之间相关性的队列研究，进行系统回顾和剂量反应荟萃分析。由两位作者提取一式两份的数据。采用随机效应剂量-反应荟萃分析来估计关联程度。曲线关联采用单阶段加权混合效应荟萃分析建模。
确定的216项队列研究共包括2600万名参与者，其中230万名患有2型糖尿病。体重指数增加5个单位的相对风险为1.72（182项研究），腰围增加10厘米为1.61（78项），腰臀比增加0.1个单位为1.63（34项），腰高比增加0.1个单位为1.73（25项），内脏脂肪指数增加1个单位为1.42（9项），体脂率增加10%为2.05（6项），身形指数增加0.005个单位为1.09（5项），身体肥胖指数增加10%为2.55（4项），臀围增加10厘米时为1.11（14项）。
体重指数与2型糖尿病风险之间存在着很强的线性正相关关系。在所有地区和种族中也发现了正线性或单调相关，在特定的临界值上没有明显的线性偏离。与总体肥胖无关的中心性肥胖指数也与2型糖尿病风险呈线性或单调正相关。尽管研究数量较少，但总脂肪量和内脏脂肪量也存在线性或单调正相关。
研究结果表明，体重指数越高，患2型糖尿病的风险越高。除总体肥胖之外，较大的腰围与2型糖尿病的风险呈强线性相关。
附：英文原文
Title: Anthropometric and adiposity indicators and risk of type 2 diabetes: systematic review and dose-response meta-analysis of cohort studies
Author: Ahmad Jayedi, Sepideh Soltani, Sheida Zeraat-talab Motlagh, Alireza Emadi, Hosein Shahinfar, Hanieh Moosavi, Sakineh Shab-Bidar
Issue&Volume: 2022/01/18
Abstract:
Objective To present a comprehensive review of the association between measures of body weight, waist, and fat, and different ratios of these measures, and the risk of type 2 diabetes.
Design Systematic review and dose-response meta-analysis of cohort studies.
Data sources PubMed, Scopus, and Web of Science up to 1 May 2021.
Review methods Cohort studies looking at the association between general or central adiposity and body fat content and the risk of type 2 diabetes in the general adult population were included. Two of the authors extracted the data in duplicate. Random effects dose-response meta-analyses were performed to estimate the degree of the associations. Curvilinear associations were modelled with a one stage weighted mixed effects meta-analysis.
Results 216 cohort studies with 2.3 million individuals with type 2 diabetes among 26 million participants were identified. Relative risks were 1.72 (95% confidence interval 1.65 to 1.81; n=182 studies) for an increase in body mass index of 5 units, 1.61 (1.52 to 1.70; n=78) for a 10 cm larger waist circumference, 1.63 (1.50 to 1.78; n=34) for an increase in waist-to-hip ratio of 0.1 units, 1.73 (1.51 to 1.98; n=25) for an increase in waist-to-height ratio of 0.1 units, 1.42 (1.27 to 1.58; n=9) for an increase in visceral adiposity index of 1 unit, 2.05 (1.41 to 2.98; n=6) for a 10% higher percentage body fat, 1.09 (1.05 to 1.13, n=5) for an increase in body shape index of 0.005 units, 2.55 (1.59 to 4.10, n=4) for a 10% higher body adiposity index, and 1.11 (0.98 to 1.27; n=14) for a 10 cm larger hip circumference. A strong positive linear association was found between body mass index and the risk of type 2 diabetes. Positive linear or monotonic associations were also found in all regions and ethnicities, without marked deviation from linearity at a specific cut-off value. Indices of central fatness, independent of overall adiposity, also had positive linear or monotonic associations with the risk of type 2 diabetes. Positive linear or monotonic associations were also found for total and visceral fat mass, although the number of studies was small.
Conclusions A higher body mass index was associated with a greater risk of developing type 2 diabetes. A larger waist circumference, independent of overall adiposity, was strongly and linearly associated with the risk of type 2 diabetes.
DOI: 10.1136/bmj-2021-067516
Source: https://www.bmj.com/content/376/bmj-2021-067516
BMJ-British Medical Journal:《英国医学杂志》，创刊于1840年。隶属于BMJ出版集团，最新IF：93.333
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本期文章：《英国医学杂志》：Online/在线发表
