小柯机器人

美国哥伦比亚大学Rui M. Costa、Anders Nelson等研究人员合作发现，皮质脊髓群向脊髓和纹状体回路传播复杂的运动信号。相关论文于2021年11月4日在线发表在《自然—神经科学》杂志上。

利用小鼠的解剖学和电生理学电路映射技术，研究人员揭示了背外侧纹状体是皮质脊髓神经元（CSN）侧枝神经支配的主要靶标。研究人员发现，这种神经支配是有倾向性的，因此针对不同纹状体通路的CSN显示出对脊髓回路的偏向性。与更多的传统观点相反，CSN不仅编码单个运动，而且还编码与运动序列的开始和偏移有关的信息。此外，类似的活动模式是由针对不同纹状体回路的CSN群体传播的。这些研究结果揭示了前脑和脊柱回路之间协调连接的逻辑，其中独立的CSN模块向下游回路传播类似的复杂信息，这表明突触后连接的差异决定了运动的特异性。

据了解，许多运动控制模型强调感觉运动皮层在运动中的作用，主要是通过CSN对脊髓的投射。此外，CSN拥有广阔的脊柱上轴突旁路，其功能组织在很大程度上是未知的。

附：英文原文

Title: Corticospinal populations broadcast complex motor signals to coordinated spinal and striatal circuits

Author: Nelson, Anders, Abdelmesih, Brenda, Costa, Rui M.

Issue&Volume: 2021-11-04

Abstract: Many models of motor control emphasize the role of sensorimotor cortex in movement, principally through the projections that corticospinal neurons (CSNs) make to the spinal cord. Additionally, CSNs possess expansive supraspinal axon collaterals, the functional organization of which is largely unknown. Using anatomical and electrophysiological circuit-mapping techniques in the mouse, we reveal dorsolateral striatum as the preeminent target of CSN collateral innervation. We found that this innervation is biased so that CSNs targeting different striatal pathways show biased targeting of spinal cord circuits. Contrary to more conventional perspectives, CSNs encode not only individual movements, but also information related to the onset and offset of motor sequences. Furthermore, similar activity patterns are broadcast by CSN populations targeting different striatal circuits. Our results reveal a logic of coordinated connectivity between forebrain and spinal circuits, where separate CSN modules broadcast similarly complex information to downstream circuits, suggesting that differences in postsynaptic connectivity dictate motor specificity. The authors detail principles underlying the innervation of spinal and striatal circuits by populations of corticospinal neurons, and characterize the behavioral information broadcast through this motor control network.

DOI: 10.1038/s41593-021-00939-w

Source: https://www.nature.com/articles/s41593-021-00939-w

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex