加拿大多伦多大学M. Cristina Nostro、Sara S. Nunes等研究人员合作发现，微血管可促进人类胰岛的移植和功能。相关论文于2021年9月3日在线发表在《细胞—干细胞》杂志上。
据研究人员介绍，胰岛移植是治疗1型糖尿病（T1D）的一种有希望的方法，然而，捐赠者数量少，胰岛移植效果差，以及终身免疫抑制使其无法成为治疗的标准。人类胚胎干细胞（hESC）衍生的胰腺细胞可以避免捐赠者的短缺，但需要干预措施来改善移植的存活率。
通过采用基于从脂肪组织中分离出来的现成微血管（MV）的独特血管化策略，研究人员加强了皮下移植。这导致了人类胰岛和hESC衍生的胰腺细胞的细胞存活率和有效的葡萄糖反应提高，从而改善了三个T1D小鼠模型中预先存在的糖尿病。
附：英文原文
Title: Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models
Author: Yasaman Aghazadeh, Frankie Poon, Farida Sarangi, Frances T.M. Wong, Safwat T. Khan, Xuetao Sun, Rupal Hatkar, Brian J. Cox, Sara S. Nunes, M. Cristina Nostro
Issue&Volume: 2021-09-03
Abstract: Islet transplantation is a promising treatment for type 1 diabetes (T1D), yet thelow donor pool, poor islet engraftment, and life-long immunosuppression prevent itfrom becoming the standard of care. Human embryonic stem cell (hESC)-derived pancreaticcells could eliminate donor shortages, but interventions to improve graft survivalare needed. Here, we enhanced subcutaneous engraftment by employing a unique vascularizationstrategy based on ready-made microvessels (MVs) isolated from the adipose tissue.This resulted in improved cell survival and effective glucose response of both humanislets and hESC-derived pancreatic cells, which ameliorated preexisting diabetes inthree mouse models of T1D.
DOI: 10.1016/j.stem.2021.08.001
Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00338-6
Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
官方网址：https://www.cell.com/cell-stem-cell/home
投稿链接：https://www.editorialmanager.com/cell-stem-cell/default.aspx
本期文章：《细胞—干细胞》：Online/在线发表
