小柯机器人

美国弗吉尼亚联邦大学Danielle M. Dick、荷兰阿姆斯特丹自由大学Philipp D. Koellinger等研究人员合作揭示自我调节和成瘾相关特质的遗传关联。相关论文于2021年8月26日在线发表在《自然—神经科学》杂志上。

研究人员采用了一种多变量方法，利用外向性行为特征之间的遗传相关性进行全基因组关联分析。通过汇集约150万人的数据，这个方法在统计学上比单一性状分析更强大，并确定了500多个遗传位点。这些位点富集了在大脑中表达的基因和与神经系统发育有关的基因。

根据结果构建的多基因评分预测了一系列不属于全基因组分析的行为和医疗结果，包括到目前为止缺乏表现良好的多基因评分的性状，如阿片类药物使用障碍、自杀、HIV感染、刑事定罪和失业。这些发现与以下观点一致：自我调节方面的持续困难可以被概念化为一种神经发育特征，具有复杂和深远的社会和健康相关性。

据介绍，与自我调节有关的行为和障碍，如药物使用、反社会行为和注意力缺陷/多动障碍，被统称为外向性行为，并具有共同的遗传关联。

附：英文原文

Title: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Author: Karlsson Linnr, Richard, Mallard, Travis T., Barr, Peter B., Sanchez-Roige, Sandra, Madole, James W., Driver, Morgan N., Poore, Holly E., de Vlaming, Ronald, Grotzinger, Andrew D., Tielbeek, Jorim J., Johnson, Emma C., Liu, Mengzhen, Rosenthal, Sara Brin, Ideker, Trey, Zhou, Hang, Kember, Rachel L., Pasman, Jolle A., Verweij, Karin J. H., Liu, Dajiang J., Vrieze, Scott, Kranzler, Henry R., Gelernter, Joel, Harris, Kathleen Mullan, Tucker-Drob, Elliot M., Waldman, Irwin D., Palmer, Abraham A., Harden, K. Paige, Koellinger, Philipp D., Dick, Danielle M.

Issue&Volume: 2021-08-26

Abstract: Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and have shared genetic liability. We applied a multivariate approach that leverages genetic correlations among externalizing traits for genome-wide association analyses. By pooling data from ~1.5 million people, our approach is statistically more powerful than single-trait analyses and identifies more than 500 genetic loci. The loci were enriched for genes expressed in the brain and related to nervous system development. A polygenic score constructed from our results predicts a range of behavioral and medical outcomes that were not part of genome-wide analyses, including traits that until now lacked well-performing polygenic scores, such as opioid use disorder, suicide, HIV infections, criminal convictions and unemployment. Our findings are consistent with the idea that persistent difficulties in self-regulation can be conceptualized as a neurodevelopmental trait with complex and far-reaching social and health correlates.

DOI: 10.1038/s41593-021-00908-3

Source: https://www.nature.com/articles/s41593-021-00908-3

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex