美国洛克菲勒大学Elaine Fuchs研究组揭示炎症记忆的建立、维持和回忆。相关论文于2021年7月27日在线发表在《细胞—干细胞》杂志上。
研究人员以小鼠表皮干细胞为模型，阐明了细胞如何建立、维持和回忆炎症记忆。具体来说，研究人员对染色质可及性、组蛋白修饰和转录因子结合的时间性动态变化进行了研究，这些变化发生在炎症期间、解决后和损伤后的记忆召回时。研究人员发现了一般应激反应转录因子FOS的一个重要的、统一的作用，它与JUN合作，并与刺激特异性STAT3合作建立记忆；然后JUN与其他稳态因子保持在记忆域上，促进FOS的快速重新招募以及基因在再次感染中重新激活。
因此，研究人员提供了一个全面的、可能是炎症记忆背后的通用机制，以及对健康和疾病中的组织健康有深远影响的回忆现象。
据介绍，近一个世纪以来，人们已经知道，但通过仍然难以捉摸的机制，细胞保留了炎症记忆，使它们能够对不同的次级刺激作出快速和广泛的反应。
附：英文原文
Title: Establishment, maintenance, and recall of inflammatory memory
Author: Samantha B. Larsen, Christopher J. Cowley, Sairaj M. Sajjath, Douglas Barrows, Yihao Yang, Thomas S. Carroll, Elaine Fuchs
Issue&Volume: 2021-07-27
Abstract: Known for nearly a century but through mechanisms that remain elusive, cells retaina memory of inflammation that equips them to react quickly and broadly to diversesecondary stimuli. Using murine epidermal stem cells as a model, we elucidate howcells establish, maintain, and recall inflammatory memory. Specifically, we landscapeand functionally interrogate temporal, dynamic changes to chromatin accessibility,histone modifications, and transcription factor binding that occur during inflammation,post-resolution, and in memory recall following injury. We unearth an essential, unifyingrole for the general stress-responsive transcription factor FOS, which partners withJUN and cooperates with stimulus-specific STAT3 to establish memory; JUN then remainswith other homeostatic factors on memory domains, facilitating rapid FOS re-recruitmentand gene re-activation upon diverse secondary challenges. Extending our findings,we offer a comprehensive, potentially universal mechanism behind inflammatory memoryand less discriminate recall phenomena with profound implications for tissue fitnessin health and disease.
DOI: 10.1016/j.stem.2021.07.001
Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00286-1
Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
官方网址：https://www.cell.com/cell-stem-cell/home
投稿链接：https://www.editorialmanager.com/cell-stem-cell/default.aspx
本期文章：《细胞—干细胞》：Online/在线发表
