美国佛蒙特大学B. Chaarani小组在研究中取得进展。他们揭示了青少年大脑认知发育 (ABCD)研究中青春期前大脑基线的功能。2021年6月7日出版的《自然-神经科学》杂志发表了这项成果。
研究人员揭示了在脑基线完成的功能性 MRI (fMRI) 任务的激活模式，这些任务旨在通过停止信号任务 (SST; N = 5,547)、奖励预期和接受物质激励延迟 (MID) 任务来测量认知冲动控制(N = 6,657) 以及对情绪 N-back (EN-back) 任务的工作记忆和情绪反应 (N = 6,009)。
此外，研究人员还通过评估血氧水平依赖性(BOLD) 激活的组间顶点/体素相关性来完成激活模式的空间重现。研究揭示了与已发表文献报道一致的强大大脑激活，在 fMRI 任务/对比中有所不同，并且与任务中的个人行为表现略相关。这些结果揭示了青春期前大脑基线的功能，为横向分析解释提供了指导，并将有助于了解青春期发育过程中大脑的纵向变化。
据介绍，ABCD研究是一项对 9 岁和 10 岁儿童进行的10 年追踪研究。每两年进行一系列神经影像学观察，以跟踪神经发育并识别大脑功能的个体差异。
附：英文原文
Title: Baseline brain function in the preadolescents of the ABCD Study
Author: B. Chaarani, S. Hahn, N. Allgaier, S. Adise, M. M. Owens, A. C. Juliano, D. K. Yuan, H. Loso, A. Ivanciu, M. D. Albaugh, J. Dumas, S. Mackey, J. Laurent, M. Ivanova, D. J. Hagler, M. D. Cornejo, S. Hatton, A. Agrawal, L. Aguinaldo, L. Ahonen, W. Aklin, A. P. Anokhin, J. Arroyo, S. Avenevoli, D. Babcock, K. Bagot, F. C. Baker, M. T. Banich, D. M. Barch, H. Bartsch, A. Baskin-Sommers, J. M. Bjork, D. Blachman-Demner, M. Bloch, R. Bogdan, S. Y. Bookheimer, F. Breslin, S. Brown, F. J. Calabro, V. Calhoun, B. J. Casey, L. Chang, D. B. Clark, C. Cloak, R. T. Constable, K. Constable, R. Corley, L. B. Cottler, S. Coxe, R. K. Dagher, A. M. Dale, M. Dapretto, R. Delcarmen-Wiggins, A. S. Dick, E. K. Do, N. U. F. Dosenbach, G. J. Dowling, S. Edwards, T. M. Ernst, D. A. Fair, C. C. Fan, E. Feczko, S. W. Feldstein-Ewing, P. Florsheim, J. J. Foxe, E. G. Freedman, N. P. Friedman, S. Friedman-Hill, B. F. Fuemmeler, A. Galvan, D. G. Gee, J. Giedd, M. Glantz, P. Glaser, J. Godino
Issue&Volume: 2021-06-07
Abstract: The Adolescent Brain Cognitive Development (ABCD) Study is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N=5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N=6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N=6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.
DOI: 10.1038/s41593-021-00867-9
Source: https://www.nature.com/articles/s41593-021-00867-9
Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex
本期文章：《自然—神经科学》：Online/在线发表
