小柯机器人

美国国立卫生研究院Marc L. Reitman、Ramón A. Piñol等研究人员合作发现，视前BRS3神经元通过多种途径提高体温和心率。这一研究成果于2021年5月25日在线发表在国际学术期刊《细胞—代谢》上。

研究人员表示，视前区（POA）是调节体温（Tb），决定控制Tb的热源、心血管和行为反应的关键大脑区域。先前表征的POA神经元群体在激活后都会降低Tb。

通过使用小鼠，研究人员将表达bombesin样受体3的POA神经元（POA^BRS3）鉴定为其激活增加Tb的群体。相反，对这些神经元的急性抑制作用可降低Tb。投射到下丘脑室旁核或背侧丘脑下丘脑的POA^BRS3神经元通过交感神经系统增加了Tb、心率和血压。POA^BRS3神经元的长期失活导致Tb变异性增加、Tb设定点的上升和下降均过高，RNA表达谱提示出多种类型的POA^BRS3神经元。因此，POA^BRS3神经元群体调节Tb和心率，有助于防寒，并微调Tb的反馈控制。这些发现促进了对恒温（哺乳动物生物的一种定义性特征）的理解。

附：英文原文

Title: Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways

Author: Ramón A. Piol, Allison S. Mogul, Colleen K. Hadley, Atreyi Saha, Chia Li, Vojtěch kop, Haley S. Province, Cuiying Xiao, Oksana Gavrilova, Michael J. Krashes, Marc L. Reitman

Issue&Volume: 2021-05-25

Abstract: The preoptic area (POA) is a key brain region for regulation of body temperature (Tb),dictating thermogenic, cardiovascular, and behavioral responses that control Tb. Previouslycharacterized POA neuronal populations all reduced Tb when activated. Using mice,we now identify POA neurons expressing bombesin-like receptor 3 (POABRS3) as a population whose activation increased Tb; inversely, acute inhibition of theseneurons reduced Tb. POABRS3 neurons that project to either the paraventricular nucleus of the hypothalamus orthe dorsomedial hypothalamus increased Tb, heart rate, and blood pressure via thesympathetic nervous system. Long-term inactivation of POABRS3 neurons caused increased Tb variability, overshooting both increases and decreasesin Tb set point, with RNA expression profiles suggesting multiple types of POABRS3 neurons. Thus, POABRS3 neuronal populations regulate Tb and heart rate, contribute to cold defense, andfine-tune feedback control of Tb. These findings advance understanding of homeothermy,a defining feature of mammalian biology.

DOI: 10.1016/j.cmet.2021.05.001

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00218-7

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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