小柯机器人

美国BostonGene Nathan Fowler和Ravshan Ataullakhanov研究团队合作在研究中取得进展。他们发现保守的泛癌微环境亚型可预测患者对免疫疗法的反应。2021年5月20日，国际学术期刊《癌细胞》在线发表了这一成果。

通过对超过10,000名癌症患者的转录组进行肿瘤微环境（TME）分类，研究人员在20种不同癌症中鉴定到4种保守的TME亚型。在多种癌症中，TME亚型与患者对免疫治疗的反应相关，拥有免疫反应性TME亚型的患者从免疫治疗中受益最大。因此，由于包含了恶性和微环境成分，TME亚型可作为许多癌症患者是否适用免疫治疗的生物标志物。

整合转录组学和基因组数据的可视化工具提供了完整的肿瘤图谱、描述了肿瘤结构、突变负荷、免疫组成、抗肿瘤免疫力和免疫抑制性逃逸的机制。整合分析加可视化可能有助于发现新的生物标记物和个性化治疗方案。

据悉，适用于临床的分子靶向疗法正在迅速发展，但其主要集中在改变基因组。转录组学分析为剖析肿瘤的复杂性提供了机会，其中包括TME，它是影响癌症进展和治疗结果的关键介质。

附：英文原文

Title: Conserved pan-cancer microenvironment subtypes predict response to immunotherapy

Author: Alexander Bagaev, Nikita Kotlov, Krystle Nomie, Viktor Svekolkin, Azamat Gafurov, Olga Isaeva, Nikita Osokin, Ivan Kozlov, Felix Frenkel, Olga Gancharova, Nava Almog, Maria Tsiper, Ravshan Ataullakhanov, Nathan Fowler

Issue&Volume: 2021-05-20

Abstract: The clinical use of molecular targeted therapy is rapidly evolving but has primarilyfocused on genomic alterations. Transcriptomic analysis offers an opportunity to dissectthe complexity of tumors, including the tumor microenvironment (TME), a crucial mediatorof cancer progression and therapeutic outcome. TME classification by transcriptomicanalysis of >10,000 cancer patients identifies four distinct TME subtypes conservedacross 20 different cancers. The TME subtypes correlate with patient response to immunotherapyin multiple cancers, with patients possessing immune-favorable TME subtypes benefitingthe most from immunotherapy. Thus, the TME subtypes act as a generalized immunotherapybiomarker across many cancer types due to the inclusion of malignant and microenvironmentcomponents. A visual tool integrating transcriptomic and genomic data provides a globaltumor portrait, describing the tumor framework, mutational load, immune composition,anti-tumor immunity, and immunosuppressive escape mechanisms. Integrative analysesplus visualization may aid in biomarker discovery and the personalization of therapeuticregimens.

DOI: 10.1016/j.ccell.2021.04.014

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00222-1

Cancer Cell：《癌细胞》，创刊于2002年。隶属于细胞出版社，最新IF：38.585
官方网址：https://www.cell.com/cancer-cell/home
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