小柯机器人

美国纪念斯隆凯特琳癌症中心Luis F. Parada、Daochun Sun等研究人员合作发现，干细胞样细胞驱动与NF1相关的MPNST功能异质性和肿瘤进展。相关论文于2021年5月18日在线发表于国际学术期刊《细胞—干细胞》。

研究人员表示，NF1相关的恶性周围神经鞘瘤（MPNST）是神经纤维瘤病死亡的主要原因。MPNST是起源于胚胎神经嵴细胞谱系的良性周围神经丛状神经纤维瘤。

使用在多个NF1 MPNST小鼠模型中标记早期神经嵴谱系细胞的报告转基因，研究人员发现并鉴定了具有干细胞样特性（包括静止）的罕见MPNST细胞群体，这对于肿瘤的发生和复发至关重要。分离这些细胞后，研究人员获得了包括癌症胚胎干神经共有基因在内的癌症干细胞特异性基因表达特征，并将Nestin鉴定为MPNST源细胞的标志物。结合癌症干细胞靶向和抗有丝分裂化学疗法可产生有效的肿瘤抑制作用并延长生存期。同源人类肿瘤中癌症干细胞标志物的富集支持了癌症干细胞与MPNST治疗发展的普遍性和相关性。

附：英文原文

Title: Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression

Author: Daochun Sun, Xuanhua P. Xie, Xiyuan Zhang, Zilai Wang, Sameer Farouk Sait, Swathi V. Iyer, Yu-Jung Chen, Rebecca Brown, Dan R. Laks, Mollie E. Chipman, Jack F. Shern, Luis F. Parada

Issue&Volume: 2021-05-18

Abstract: NF1-associated malignant peripheral nerve sheath tumors (MPNSTs) are the major causeof mortality in neurofibromatosis. MPNSTs arise from benign peripheral nerve plexiformneurofibromas that originate in the embryonic neural crest cell lineage. Using reportertransgenes that label early neural crest lineage cells in multiple NF1 MPNST mousemodels, we discover and characterize a rare MPNST cell population with stem-cell-likeproperties, including quiescence, that is essential for tumor initiation and relapse.Following isolation of these cells, we derive a cancer-stem-cell-specific gene expressionsignature that includes consensus embryonic neural crest genes and identify Nestinas a marker for the MPNST cell of origin. Combined targeting of cancer stem cellsalong with antimitotic chemotherapy yields effective tumor inhibition and prolongssurvival. Enrichment of the cancer stem cell signature in cognate human tumors supportsthe generality and relevance of cancer stem cells to MPNST therapy development.

DOI: 10.1016/j.stem.2021.04.029

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00187-9

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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