小柯机器人

德国Hamburg-Eppendorf大学医学中心Tobias H. Donner、Peter R. Murphy等研究人员合作揭示证据积累过程中人类大脑皮层的适应性回路动态。这一研究成果于2021年4月26日在线发表在国际学术期刊《自然—神经科学》上。

研究人员分析了在不断变化的环境中视觉证据积累过程中记录的人类行为和皮层群体活动（用脑磁图测量）。参与行动计划的皮层区域中与行为和决策相关的活动表现出适应性证据积累的标志，这也可以通过循环皮质微电路来实现。

动作编码的顶叶和额叶区域的决策动态反映在视皮层状态的特定频率调制中，这取决于瞳孔关联的唤醒和预期的变化概率。这些发现将标准的决策计算与循环皮层回路动力学联系起来，并突出了与决策相关的反馈到感觉皮层的适应性。

据了解，在不确定性下的许多决定需要时间上的证据积累，这能够提供环境状况。当环境的状态发生隐式变化时，要使准确性和回报最大化就需要非线性的证据积累。在大脑中如何实现这种自适应的非线性计算是未知的。

附：英文原文

Title: Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments

Author: Peter R. Murphy, Niklas Wilming, Diana C. Hernandez-Bocanegra, Genis Prat-Ortega, Tobias H. Donner

Issue&Volume: 2021-04-26

Abstract: Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are subject to hidden changes in their state, maximizing accuracy and reward requires non-linear accumulation of evidence. How this adaptive, non-linear computation is realized in the brain is unknown. We analyzed human behavior and cortical population activity (measured with magnetoencephalography) recorded during visual evidence accumulation in a changing environment. Behavior and decision-related activity in cortical regions involved in action planning exhibited hallmarks of adaptive evidence accumulation, which could also be implemented by a recurrent cortical microcircuit. Decision dynamics in action-encoding parietal and frontal regions were mirrored in a frequency-specific modulation of the state of the visual cortex that depended on pupil-linked arousal and the expected probability of change. These findings link normative decision computations to recurrent cortical circuit dynamics and highlight the adaptive nature of decision-related feedback to the sensory cortex. Optimal decision making in a changing world requires non-linear evidence accumulation. Murphy et al. report signatures of this adaptive computation in recurrent dynamics of human parietal and motor cortices, accompanied by feedback to sensory cortex.

DOI: 10.1038/s41593-021-00839-z

Source: https://www.nature.com/articles/s41593-021-00839-z

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex