小柯机器人

美国加州大学圣地亚哥分校Duygu Kuzum和Takaki Komiyama研究组合作取得最新进展。他们使用灵活、可插入且透明的微电极阵列（Neuro-FITM）进行的多模式神经记录揭示了皮层-海马相互作用的多种模式。这一研究成果于2021年4月19日发表在国际顶尖学术期刊《自然-神经科学》 上。

他们开发了Neuro-FITM，可用于研究海马锐波波纹（SWR）期间皮质与海马之间的协调性。Neuro-FITM的灵活性和透明性允许在宽场钙成像期间同时记录局部场电势和海马神经尖峰。这些实验表明，不同的皮质活动模式伴随着SWR，并且在大多数情况下，皮质激活先于海马SWR。他们证明，在SWR期间，不同的海马神经种群活动与不同的皮层活动模式相关。

这些结果表明，在各种认知功能潜在的SWR期间，海马和大规模皮层活动以选择性和多样化的方式相互作用。他们的技术可以广泛应用于皮质与其他皮质下结构之间相互作用的综合研究。

据悉，许多认知过程需要在新皮质和海马之间进行交流。然而，由于在这些区域同时进行记录有困难，因此大规模皮层动力学与海马活动之间的协调性尚不十分清楚。

附：英文原文

Title: Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions

Author: Xin Liu, Chi Ren, Yichen Lu, Yixiu Liu, Jeong-Hoon Kim, Stefan Leutgeb, Takaki Komiyama, Duygu Kuzum

Issue&Volume: 2021-04-19

Abstract: Many cognitive processes require communication between the neocortex and the hippocampus. However, coordination between large-scale cortical dynamics and hippocampal activity is not well understood, partially due to the difficulty in simultaneously recording from those regions. In the present study, we developed a flexible, insertable and transparent microelectrode array (Neuro-FITM) that enables investigation of cortical–hippocampal coordinations during hippocampal sharp-wave ripples (SWRs). Flexibility and transparency of Neuro-FITM allow simultaneous recordings of local field potentials and neural spiking from the hippocampus during wide-field calcium imaging. These experiments revealed that diverse cortical activity patterns accompanied SWRs and, in most cases, cortical activation preceded hippocampal SWRs. We demonstrated that, during SWRs, different hippocampal neural population activity was associated with distinct cortical activity patterns. These results suggest that hippocampus and large-scale cortical activity interact in a selective and diverse manner during SWRs underlying various cognitive functions. Our technology can be broadly applied to comprehensive investigations of interactions between the cortex and other subcortical structures.

DOI: 10.1038/s41593-021-00841-5

Source: https://www.nature.com/articles/s41593-021-00841-5

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex